Dengue Virus

Murugesan, Amudhan; Mythreyee, Manoharan

doi:10.1016/b978-0-12-819400-3.00016-8

Cited by 107 publications

(68 citation statements)

References 334 publications

(355 reference statements)

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“…The World Health Organization (WHO) estimates an annual incidence of approximately 100 million infections, with approximately 500,000 severe dengue cases leading to almost 25,000 deaths annually [ 1 ]. Dengue virus (DENV) with four antigenically distinct serotypes belongs to the Flaviviridae family and contains a positive-sense single-stranded RNA genome with a size of approximately 11 kb [ 2 ]. Transmission of DENV infection occurs through the bite of female mosquito vectors Aedes aegypti and Aedes albopictus [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Antiviral Activity of α-Mangostin against Dengue Virus Serotype-2 (DENV-2)

et al. 2021

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Dengue virus (DENV), a member of the family Flaviviridae, is a threat for global health as it infects more than 100 million people yearly. Approved antiviral therapies or vaccines for the treatment or prevention of DENV infections are not available. In the present study, natural compounds were screened for their antiviral activity against DENV by in vitro cell line-based assay. α-Mangostin, a xanthanoid, was observed to exert antiviral activity against DENV-2 under pre-, co- and post-treatment testing conditions. The antiviral activity was determined by foci forming unit (FFU) assay, quantitative RT-PCR and cell-based immunofluorescence assay (IFA). A complete inhibition of DENV-2 was observed at 8 µM under the co-treatment condition. The possible inhibitory mechanism of α-Mangostin was also determined by docking studies. The molecular docking experiments indicate that α-Mangostin can interact with multiple DENV protein targets such as the NS5 methyltransferase, NS2B-NS3 protease and the glycoprotein E. The in vitro and in silico findings suggest that α-Mangostin possesses the ability to suppress DENV-2 production at different stages of its replication cycle and might act as a prophylactic/therapeutic agent against DENV-2.

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Section: Introductionmentioning

confidence: 99%

In Vitro Antiviral Activity of α-Mangostin against Dengue Virus Serotype-2 (DENV-2)

et al. 2021

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“…DENV is a member of the Flavivirus genus of the Flaviviridae family of single-stranded positive sense RNA viruses [ 5 ] and exists as four closely related serotypes, DENV-1-4 [ 6 , 7 ]. Although other regions in Southeast Asia have reported dengue outbreaks since the 1950s, Myanmar recorded its first outbreak in the 1970s.…”

Section: Introductionmentioning

confidence: 99%

Emergence of a Novel Dengue Virus 3 (DENV-3) Genotype-I Coincident with Increased DENV-3 Cases in Yangon, Myanmar between 2017 and 2019

Soe

Tun

Nabeshima

et al. 2021

Viruses

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Dengue fever, caused by the mosquito-borne dengue virus (DENV), has been endemic in Myanmar since 1970 and it has become a significant public health burden. It is crucial that circulating DENV strains are identified and monitored, and that their transmission efficiency and association with disease severity is understood. In this study, we analyzed DENV-1, DENV-2, DENV-3, and DENV-4 serotypes in 1235 serum samples collected in Myanmar between 2017 and 2019. Whole-genome sequencing of DENV-1–4 demonstrated that most DENV-1–4 strains had been circulating in Myanmar for several years. We also identified the emergence of DENV-3 genotype-I in 2017 samples, which persisted through 2018 and 2019. The emergence of the strain coincided with a period of increased DENV-3 cases and marked changes in the serotype dynamics. Nevertheless, we detected no significant differences between serum viral loads, disease severity, and infection status of individuals infected with different DENV serotypes during the 3-year study. Our results not only identify the spread of a new DENV-3 genotype into Yangon, Myanmar, but also support the importance of DENV evolution in changing the epidemic dynamics in endemic regions.

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“…Its genome consists of a single-stranded RNA chain, approximately 10.8 kb in length and open reading frame (ORF) that encodes a single polyprotein which is cleaved into the structural proteins: capsid (C), membrane (M) and envelope (E); and eight nonstructural proteins (NS): NS1, NS2A, NS2B, NS3, NS4A, NS2K, NS4B and NS5, responsible for assist in viral genome replication. The M protein is synthesized as a precursor protein (prM), being cleaved by cellular protease to generate mature status (Murugesan & Manoharan, 2020).…”

Section: General Aspects Of Dengue Zika Fever and Chikungunyamentioning

confidence: 99%

Dengue, Zika Fever e Chikungunya: Aspectos Biológicos e Situação na América do Sul entre 2015 e 2020

Silva

Araújo

Barbosa

2021

RSD

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Arboviroses são doenças causadas por vírus transmitidos por artrópodes e afetam as Américas, incluindo a América do Sul, onde provocam impactos na economia e na saúde pública. Entre os mais de 500 vírus registrados no Catálogo Internacional de Arbovírus, destacam-se os que causam dengue, febre zika e chikungunya. Assim, este artigo compreende um estudo descritivo baseado em dados secundários, onde são comparados aspectos biológicos e diagnósticos em relação a essas três enfermidades, bem como avaliamos sua presença, entre 2015 e 2020, nos países que integram a porção continental sul-americana. Apesar do considerável progresso feito nos últimos anos para melhor compreender os aspectos moleculares dos agentes etiológicos e das condições clínicas, o cenário é complexo e os três arbovírus causaram surtos na América do Sul, no período descrito, em proporções diferentes, e a dengue a mais comum, cujas taxas de incidência variam a cada ano analisado. O combate aos arbovírus deve ser permanente e requer políticas intersetoriais bem fundamentadas e responsabilidade individual. As intervenções governamentais precisam estreitar-se para implementar medidas de combate, e os sistemas de saúde e educação poderiam se alinhar de forma mais eficaz a fim de um trabalho mais forte de sensibilização que seja desencadeado desde os alunos da educação básica, auxiliando na educação continuada da população a favor da uma sociedade mais orientada e prudente. Também é necessário refletir sobre a eficácia dos sistemas de informações a fim de minimizar o problema da subnotificação, que impede de mostrar o real cenário dessas doenças.

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Dengue Virus

Cited by 107 publications

References 334 publications

In Vitro Antiviral Activity of α-Mangostin against Dengue Virus Serotype-2 (DENV-2)

In Vitro Antiviral Activity of α-Mangostin against Dengue Virus Serotype-2 (DENV-2)

Emergence of a Novel Dengue Virus 3 (DENV-3) Genotype-I Coincident with Increased DENV-3 Cases in Yangon, Myanmar between 2017 and 2019

Dengue, Zika Fever e Chikungunya: Aspectos Biológicos e Situação na América do Sul entre 2015 e 2020

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