Skin-Reactive Soluble Antigen From Intestinal Cancer-Cell-Membranes and Relationship to Carcinoembryonic Antigens

Hollinshead, Ariel C.; Glew, Donald H.; Bunnag, Bill; Gold, Phil; Herberman, Ronald B.

doi:10.1016/s0140-6736(70)91784-8

Cited by 78 publications

(22 citation statements)

References 14 publications

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“…Thus growth of colonic cancer target cells in vitro is inhibited by previous exposure to lymphocytes from tumour-bearing patients (Hellstr6m et al, 1968) and lymphocytotoxicity for colonic cancer cells can be demonstrated (Nairn et al, 1971). Delayed hypersensitivity reactions can also be produced by intradermal injections of soluble fractions obtained from the membranes of tumour cells (Hollinshead, Glew, Bunnag, Gold, and Herberman, 1970). There are at least three possible explanations for our findings.…”

Section: Discussionmentioning

confidence: 57%

Phytohaemagglutinin-induced lymphocyte transformation in patients before and after resection of large intestinal cancer

McIllmurray¹,

Gray²,

Langman³

1973

Gut

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sumMARY Lymphocyte responses to stimulation with phytohaemagglutinin (PHA) have been compared in 20 patients with large intestinal cancer, 10 patients whose large intestinal cancers have been removed, and in 30 age-and sex-matched control individuals. Responses were markedly reduced in the tumour-bearing patients and were unaffected by substituting normal for autologous plasma during incubation. Responses, however, were normal after tumour resection suggesting that the defect in lymphocyte responsiveness is a reversible one and related to the presence of tumour tissue.

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Section: Discussionmentioning

confidence: 57%

Phytohaemagglutinin-induced lymphocyte transformation in patients before and after resection of large intestinal cancer

McIllmurray¹,

Gray²,

Langman³

1973

Gut

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“…It follows that one or several carcinoembryonic antigens could behave as tumourspecific antigens. In other studies, skin tests were made with extracts of autologous colonic tumours, these extracts being the membrane-rich pellet of the tumour homogenate (Hollinshead, Glew, Bunnag, Gold, and Herberman, 1970) or prepared by perchloric acid (Hollinshead, McWright, Alford, Glew, Gold, and Herberman, 1972). Some positive delayed reactions were obtained.…”

Section: Autoimmunity and Cellular Immunology Studiesmentioning

confidence: 99%

Nature and significance of the antigens associated with human gastrointestinal tumours

Burtin¹

1974

J Clin Pathol

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“…Patients with colon carcinoma have been shown to react immunologically against tumour-associated antigens (Hellstrom et al, 1970;Hollinshead et al, 1970;. This finding suggests the use of immunotherapy to secure the surgical cure of this tumour.…”

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confidence: 99%

Immunoprophylaxis and therapy of grafted rat colonic carcinoma.

Martin¹,

Martin²,

Justrabo³

et al. 1977

Gut

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SUMMARY Two independent lines of chemically-induced colonic carcinoma, serially graftable in syngeneic rats, have been used to investigate the effects of immunoprophylaxis and immunotherapy. Rats were immunised by various procedures, including BCG, irradiated tumour grafts, and cancer cells treated by mitomycin and neuraminidase. A partial inhibition of tumour growth was observed in one of the four tested protocols. On the other hand, a significant enhancement of tumour growth was obtained in two other experiments.Patients with colon carcinoma have been shown to react immunologically against tumour-associated antigens (Hellstrom et al., 1970;Hollinshead et al., 1970;. This finding suggests the use of immunotherapy to secure the surgical cure of this tumour. Demonstration of the objective effects of immunotherapy and the choice of the most efficient method require prolonged study in humans, because of the slow evolution of colorectal cancer. For this reason, we have chosen an animal model of chemically-induced colonic cancer (Martin et al., 1973a). The following report deals with our preliminary attempts to treat rat colonic cancer by specific or non-specific immunological treatment. Methods ANIMALSAll rats were of the inbred BD-IX strain, maintained by continuous brother-sister mating. Inbreeding has been confirmed by permanent acceptance of skin grafts. TUMOURSTwo serially graftable tumour lines, DHB and DHD, were independently obtained from colonic adenocarcinomas induced by 1,2 dimethylhydrazine (Martin et al., 1973b

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Skin-Reactive Soluble Antigen From Intestinal Cancer-Cell-Membranes and Relationship to Carcinoembryonic Antigens

Cited by 78 publications

References 14 publications

Phytohaemagglutinin-induced lymphocyte transformation in patients before and after resection of large intestinal cancer

Phytohaemagglutinin-induced lymphocyte transformation in patients before and after resection of large intestinal cancer

Nature and significance of the antigens associated with human gastrointestinal tumours

Immunoprophylaxis and therapy of grafted rat colonic carcinoma.

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