Skin-Related Neglected Tropical Diseases (Skin NTDs)—A New Challenge

Hay, Roderick J.; Kingsley, Asiedu

doi:10.3390/tropicalmed4010004

Cited by 18 publications

(14 citation statements)

References 7 publications

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“…Scabies and its burdens are often regarded as a problems of people living in low and middle income countries, and commonly affects young and elder age persons [1,4]. However, scabies have several effective treatment options [5], prevention and control in the population are challenging because of the high levels of re-infestation that can occur through community and personal contacts [4,5]. The spread of scabies are high in the overcrowding area [3].…”

Section: Introductionmentioning

confidence: 99%

“…The prevalence of scabies is ranging from 0.3 to 46% and the point estimate is around 147 million worldwide [5,6] . There is a high prevalence in low and low-middle income countries [4,7].…”

Section: Introductionmentioning

confidence: 99%

“…Scabies is one of public health concerns among communicable disease in Ethiopia, especially disadvantaged people like streets, migrants and poorer [5,8]. The magnitude of scabies infestation in Ethiopia was varied which ranged from 2.5 to 78% and inconsistent [13,14].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and associated factors of scabies in Ethiopia: systematic review and Meta-analysis

2020

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Background: Scabies is an infectious disease that affects the skin caused by the mite Sarcoptes scabiei and it transmitted through close personal contact. Even though it is easily treatable disease, its prevalence is high and continuous as neglected tropical disease of resource-poor settings, and particularly affects young age groups. Despite of these facts, studies conducted in Ethiopia regarding to the prevalence and associated factors for scabies infestation have been highly variable and didn't well compiled. Due to that, the aim of this systematic review and meta-analysis was to estimates the overall prevalence of scabies and associated factors in all age groups in Ethiopia. Methods: International databases (PubMed/PMC/Midline, EMBASE, CINAHL, Web of Science, Google Scholar, Google and Science Direct) were systematically searched from December 1, 2019, to January 18, 2020. All observational studies noted the prevalence of human scabies and associated factors in Ethiopia were included. Two authors (AG and G.T) independently extracted all necessary data using a standardized data extraction format. The data which is extracted each study were analyzed using STATA Version 14.1. Heterogeneity among the included studies was assessed through the Cochrane Q test statistics and I 2 test. Lastly, a random effects meta-analysis model was computed to fix overall prevalence and associated factors of scabies. Results: Twelve studies were included in this meta-analysis after 410 articles retrieved. Of these, eight studies were analyzed for prevalence estimation. The overall prevalence of scabies infestation was 14.5% (95%CI: 1.5, 27.6%) in Ethiopia. Furthermore, the subgroup analysis revealed the highest prevalence was 19.6% in Amhara region. A person from a large family size (OR: 3.1, 95% CI: 1.76, 5.67), and sharing a bed (OR: 3.59, 95%CI: 2.88, 4.47) were significantly associated with scabies. Conclusion: This study revealed the prevalence of scabies infestation was 14.5% in Ethiopia which was high. Persons from high family size and any contact with scabies case were factors associated with scabies.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevalence and associated factors of scabies in Ethiopia: systematic review and Meta-analysis

2020

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“…Integrated programmes may allow for expanded understanding of disability and stigma associated with skin NTDs. Finally, integrated programmes for multiple skin NTDs may also lead to improved patient health outcomes over and above what can be achieved in disease‐specific programmes, through deeper engagement of local populations in line with universal health coverage 59. Scabies has already been integrated into NTD programmes in the Solomon Islands, where epidemiological mapping and scabies treatment programmes have been conducted with programmes for trachoma and yaws,60 and mass drug administration of ivermectin used to control other diseases such as onchocerciasis and lymphatic filariasis has been observed to reduce scabies in Africa 61…”

Section: Integration Of Skin Neglected Tropical Disease Programmes Anmentioning

confidence: 99%

“…[54][55][56][57][58] Strategic partnerships and an integrated approach for all skin NTDs could lead to significant financial savings and logistic improvements through common diagnostic pathways, shared approaches to mapping, compatible drug regimens and overlapping nonpharmacological management. 54,55,59 These initiatives may have an impact on our understanding of the scabies disease burden. Integrated programmes may allow for expanded understanding of disability and stigma associated with skin NTDs.…”

Section: Scabies In Closed Communitiesmentioning

confidence: 99%

Estimating the global burden of scabies: what else do we need?*

et al. 2020

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Summary Scabies is one of the most common disorders identified in any estimate of global skin disease prevalence. Furthermore, quantifying its impact on individuals and societies has been problematic. There has been a lack of clear case definitions and laboratory tests. There have been few epidemiological studies, particularly those focusing on low‐income countries, variation in prevalence within high‐income countries, or estimates of the effect of scabies on health beyond the skin, such as renal disease or mental wellbeing. Economic studies are also lacking. However, the new strategy of integrating surveillance for skin Neglected Tropical Diseases may well produce advancements on these issues, in addition to providing an overarching structure for health improvement and disease control.

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Current Progress and Prospects for a Buruli Ulcer Vaccine

Boakye-Appiah

Hall

Reljić

et al. 2023

Vaccines for Neglected Pathogens: Strategies, Achievements and Challenges

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Buruli ulcer (BU), one of the skin-related neglected tropical diseases (skin NTDs), is a necrotizing and disabling cutaneous disease caused by subcutaneous infection with Mycobacterium ulcerans. Leading on from the World Health Organization’s (WHO) establishment of a global BU initiative in 1998, >67,000 cases of BU have been reported from over 32 countries, mostly from West Africa and Australia. While treatment is currently in the transition period from rifampicin plus streptomycin (injection) to an all-oral regimen, it cannot hope to eradicate this opportunistic environmental pathogen. M. ulcerans is genetically very similar to related pathogenic organisms M. marinum, M. leprae and M. tuberculosis. However, M. ulcerans carries a unique megaplasmid, pMUM001, encoding the biosynthetic machinery responsible for production of a lipid-like exotoxin virulence factor, mycolactone. This diffusible compound causes the substantial divergence in BU’s pathogenic aetiology from other mycobacterial infections. Hence, mycolactone is cytotoxic and immunosuppressive and causes vascular dysfunction in infected skin. A major recent advance in our understanding of BU pathogenesis has been agreement on the mycolactone’s mechanism of action in host cells, targeting the Sec61 translocon during a major step in secretory and membrane protein biogenesis. While vaccine development for all mycobacteria has been challenging, mycolactone production likely presents a particular challenge in the development of a BU vaccine. The live-attenuated vaccine BCG is known to provide only partial and transient protection in humans but provides a convenient baseline in mouse preclinical studies where it can delay, but not prevent, disease progression. No experimental vaccine strategy has yet conferred greater protection than BCG. However, there is now the prospect of developing a vaccine against mycolactone itself, which may provide hope for the future.

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Skin-Related Neglected Tropical Diseases (Skin NTDs)—A New Challenge

Abstract: Medical teaching has emphasised over many years the uniqueness of disease states, valuing the rare skills on which the art of diagnosis is based and the intricacies of individual patient-centred management. [...]

Cited by 18 publications

References 7 publications

Prevalence and associated factors of scabies in Ethiopia: systematic review and Meta-analysis

Prevalence and associated factors of scabies in Ethiopia: systematic review and Meta-analysis

Estimating the global burden of scabies: what else do we need?*

Current Progress and Prospects for a Buruli Ulcer Vaccine

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