Skin Signs of Systemic Disease in Childhood

Gilliam, Amy E.

doi:10.1016/j.yadr.2006.08.003

Cited by 5 publications

(5 citation statements)

References 74 publications

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“…After puberty, CLE was more likely to occur in female subjects, with a ratio of 4·5 : 1 in those diagnosed at or after age 12 years. These numbers are comparable to those previously reported for paediatric SLE, where the sex ratio is equal until puberty when a striking female predominance is then seen . The peak incidence of CLE at 11–13 years is similar to that seen in childhood SLE and was comparable across CLE subtypes .…”

Section: Discussionsupporting

confidence: 88%

“…These numbers are comparable to those previously reported for paediatric SLE, where the sex ratio is equal until puberty when a striking female predominance is then seen. 8 The peak incidence of cutaneous LE at 11–13 years is similar to that seen in childhood SLE and was comparable across cutaneous LE subtypes. 9 Thus, our findings of sex and age distribution for cutaneous LE are different from that of adult cutaneous LE but similar to childhood-onset SLE.…”

Section: Discussionsupporting

confidence: 52%

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Demographic and clinical characteristics of cutaneous lupus erythematosus at a paediatric dermatology referral centre

Holland

Drolet

et al. 2013

Br J Dermatol

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Background Paediatric cutaneous lupus erythematosus (LE) is uncommon and inadequately described in the literature. Similar to adults, children with cutaneous LE develop LE-specific and/or LE-nonspecific skin findings. Similarities and differences in demographics and clinical course between paediatric and adult cutaneous LE have not been sufficiently described. Objectives The purpose of this study is to detail the demographic and clinical features of paediatric cutaneous LE and then compare these findings to those reported in the adult literature. Methods A retrospective chart review was performed of 53 children seen in a paediatric dermatology clinic with cutaneous manifestations of LE. Results Patients presented with all five major subtypes of cutaneous LE, with some notable differences from adult cutaneous LE and previously published reports of paediatric cutaneous LE. Progression from discoid LE to systemic lupus erythematosus (SLE) did not occur in our cohort. Patients with subacute cutaneous LE were more likely than adults to have lesions below the waist as well as concomitant SLE. Sex distribution for cutaneous LE in our study was equal prior to puberty and female-predominant in post-pubertal patients. Conclusions Children with cutaneous LE have variable clinical presentations and progression to SLE that may be different from adult disease. Specifically, children with acute and subacute cutaneous LE may be more likely than adults to have systemic disease; therefore, patients with these subtypes should be monitored closely for evidence of SLE. Study limitations included small patient numbers that may limit ability to generalize this data and relatively short follow-up intervals.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 52%

Demographic and clinical characteristics of cutaneous lupus erythematosus at a paediatric dermatology referral centre

Holland

Drolet

et al. 2013

Br J Dermatol

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“…The neutrophilic dermatoses are uncommon disorders characterized by sterile neutrophilic infiltrates in skin (1–3). The neutrophilic dermatoses share similar clinical appearances as well as associated conditions including inflammatory bowel diseases, connective tissue diseases, myeloproliferative disorders (with IgA monoclonal gammopathy), and medications (4).…”

mentioning

confidence: 99%

Neutrophilic Dermatoses in Children

Berk

Bayliss

2008

Pediatric Dermatology

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The neutrophilic dermatoses are rare disorders, especially in children, and are characterized by neutrophilic infiltrates in the skin and less commonly in extracutaneous tissue. The neutrophilic dermatoses share similar clinical appearances and associated conditions, including inflammatory bowel disease, malignancies, and medications. Overlap forms of disease demonstrating features of multiple neutrophilic dermatoses may be seen. The manuscript attempts to provide an up-to-date review of (i) classical neutrophilic dermatoses, focusing on distinctive features in children and (ii) neutrophilic dermatoses which may largely be pediatric or genodermatosis-associated (Majeed, SAPHO [synovitis, severe acne, sterile palmoplantar pustulosis, hyperostosis, and osteitis] syndrome, PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne), PFAPA (periodic fever with aphthous stomatitis, pharyngitis, and cervical adenopathy), and other periodic fever syndromes, and congenital erosive and vesicular dermatosis healing with reticulated supple scarring).

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“…Las dermatosis neutrofílicas son trastornos poco frecuentes en la infancia, que se caracterizan por la presencia de infiltrados neutrofílicos estériles en la piel y comparten aspectos clínicos similares [6][7][8] . El término general incluye dermatitis granulomatosa intersticial, granuloma de Churg-Strauss y reacción intersticial granulomatosa por fármacos 9 .…”

Section: Discussionunclassified

Dermatitis granulomatosa neutrofílica en empalizada como presentación inicial de lupus eritematoso sistémico

Henostroza-Inga¹,

Torres-Ibérico²,

Atamari‐Anahui³

et al. 2021

BMHIM

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Introducción: La dermatitis granulomatosa neutrofílica en empalizada es una manifestación cutánea poco frecuente en la infancia que se asocia con patologías autoinmunitarias. La patogénesis exacta de esta enfermedad aún se desconoce. Sin embargo, se ha sugerido que el depósito de complejos inmunitarios podría iniciarla. Caso clínico: Se describe el caso de una paciente de 11 años que presentó lesiones polimórficas en las extremidades asociadas a poliartralgias. Fue diagnosticada de lupus eritematoso sistémico y nefritis lúpica. Por las lesiones en la piel, se realizaron estudios histopatológico e inmunohistoquímico (CD68, CD163, mieloperoxidasa), que dieron como resultado dermatitis granulomatosa neutrofílica en empalizada. Debido al compromiso renal, se administró tratamiento con pulsos de metilprednisolona, además de hidroxicloroquina, micofenolato de mofetilo, antihipertensivos y antiinflamatorios no esteroideos. La respuesta clínica fue favorable durante el seguimiento. Conclusiones: La dermatitis granulomatosa neutrofílica en empalizada asociada a lupus eritematoso sistémico es inusual. Por ello, es importante su reconocimiento, ya que puede presentarse como manifestación inicial de la enfermedad autoinmunitaria.

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Skin Signs of Systemic Disease in Childhood

Cited by 5 publications

References 74 publications

Demographic and clinical characteristics of cutaneous lupus erythematosus at a paediatric dermatology referral centre

Demographic and clinical characteristics of cutaneous lupus erythematosus at a paediatric dermatology referral centre

Neutrophilic Dermatoses in Children

Dermatitis granulomatosa neutrofílica en empalizada como presentación inicial de lupus eritematoso sistémico

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