2013
DOI: 10.1007/s13671-013-0044-z
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Skin Substitutes and Dermatology: A Review

Abstract: Death from large burn wounds has pushed the development of life-saving techniques to cover and heal these wounds as rapidly as possible, resulting in a variety of tissue engineered skin substitutes available on the market. There remains a paucity of good quality RCTs evaluating the efficacy of skin substitutes, and even fewer studies comparing products to each other. While some products have been used successfully for dermatologic applications and published in the literature, a vast majority of data that we do… Show more

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Cited by 39 publications
(17 citation statements)
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“…Additionally, no clinical rejection and no humoral or cellular response to the keratinocytes or fibroblasts of Apligraf has been reported performing immunological tests in clinical trials [55]. However, allogeneic cells of the construct do not survive longer than one to two months in vivo [56][57][58].…”
Section: Epidermal Templatesmentioning
confidence: 99%
“…Additionally, no clinical rejection and no humoral or cellular response to the keratinocytes or fibroblasts of Apligraf has been reported performing immunological tests in clinical trials [55]. However, allogeneic cells of the construct do not survive longer than one to two months in vivo [56][57][58].…”
Section: Epidermal Templatesmentioning
confidence: 99%
“…Full-thickness skin graft (FTSG) consists of the epidermis, dermis, subcutaneous, and the epidermal appendages [11]. Grafting may lead to shorter average hospitalizations, reduce cost, healing time, cosmesis, and time away from work compared to CT [12,13] but may not satisfy the issues regarding cosmesis and functionality [14]. FTSG is ideal for burn injuries due to less longterm contracture and scar formation but has limited donor sites, is reserved for small defects, may not address contour distortion, and may become hyperpigmented [14][15][16].…”
Section: Introductionmentioning
confidence: 99%
“…Grafting may lead to shorter average hospitalizations, reduce cost, healing time, cosmesis, and time away from work compared to CT [12,13] but may not satisfy the issues regarding cosmesis and functionality [14]. FTSG is ideal for burn injuries due to less longterm contracture and scar formation but has limited donor sites, is reserved for small defects, may not address contour distortion, and may become hyperpigmented [14][15][16]. STSG is suitable for larger areas of injuries but can cause decreased cosmesis and increased risk of contracture [14,16].…”
Section: Introductionmentioning
confidence: 99%
“…It can be divided into three layered which are epidermis, dermis and hypodermis. These three layers have an extracellular proteinic matrix (ECM) in which it consists of three classes of biomolecules which are structural protein, specialized protein and proteoglycans and different cells apart of other structures such as blood vessels, glands, nerves and hair [3,4]. The epidermis is an outer layer in which cover all layered of our skin.…”
Section: Introductionmentioning
confidence: 99%
“…It also known as "subcutis" or "subcutaneous fat" which mainly composed of areolar connective and adipose tissue that functions as energy storage and give thermal insulation to human body [3,6]. Skin exhibits nonlinear, non-homogenous, viscoelastic and anisotropic behaviour [3,4,5], with the ability to endure large deformations. The mechanical properties of skin and behaviour are important for biomedical engineering, forensic, cosmetology and also plastic surgery [11].…”
Section: Introductionmentioning
confidence: 99%