Skin Tissue Engineering for Tissue Repair and Regeneration

Abstract

Tissue-engineered skin is a significant advance in the field of wound healing. It has mainly been developed because of limitations associated with the use of autografts and allografts where the donor site suffers from pain, infection, and scarring. Recently, tissue-engineered skin replacements have been finding widespread application, especially in the case of burns, where the major limiting factor is the availability of autologous skin. The development of a bioartificial skin facilitates the treatment of patients with deep burns and various skin-related disorders. The present review gives a comprehensive overview of the developments and future prospects of scaffolds as skin substitutes for tissue repair and regeneration.

Allogeneic Transplantation of an Adipose-Derived Stem Cell Sheet Combined With Artificial Skin Accelerates Wound Healing in a Rat Wound Model of Type 2 Diabetes and Obesity

“…The efficacy of ASC sheets with artificial skin requires further evaluation in diabetic wounds with exposed bone. In this study, the artificial skin used provided a three-dimensional framework for ASCs, maintaining transplanted ASC sheets and wounds in a moist environment, preventing wounds from spontaneous contraction, and protecting wounds from infection and external forces (22). The aim of the current study was to evaluate the efficacy of allogeneic ASC sheet transplantation with artificial skin to promote the healing and vascularization of full-thickness skin defects in a rat diabetic wound model.…”

Electrospun Nanofibers in Tissue Engineering

“…Electrospinning has been used as an approach for developing scaffolds for engineered skin and wound dressings, although less than other scaffold strategies (Priya et al, 2008). Nevertheless, several investigators have used electrospinning for skin tissue engineering.…”

“…Even though there are several studies investigating electrospun scaffolds for skin tissue engineering, to our knowledge there have yet to be any publications that investigate the use of these scaffolds in vivo. In contrast, numerous tissue engineering strategies that employ non-electrospun scaffolds have been studied in vivo (Priya et al, 2008). Regardless, electrospinning has become a simple and economical method to generate scaffolds that mimic the ECM of tissues.…”

Biomimetic Architectures for Tissue Engineering

“…Experimental data showed EPC seeded scaffolds promoted angiogenesis and microvasculature at the wound site (Kim, Han et al 2009). Newer developments in skin technology have added combinations of fibroblasts, keratinocytes or epithelial cells into biodegradable scaffolds (Priya, Jungvid et al 2008;Schulz, Tompkins et al 2000). After a designated culture time, the cells populate and remodel the matrix, creating a rudimentary living skin.…”