Skin tumorigenesis in mice by petroleum asphalts and coal-tar pitches of known polynuclear aromatic hydrocarbon content

Wallcave, Lawrence; Astiazarán-García, Humberto; Feldman, Rebecca L.; Lijinsky, William; Shubik, Philippe

doi:10.1016/0041-008x(71)90313-9

Cited by 59 publications

(18 citation statements)

References 5 publications

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“…It is likely that these men had been exposed to coal tar pitch as well as asphalt. The amount of carcinogenic PAH in coal tar is several orders of magnitude greater than in asphalt [Wallcave et al, 1971;Darby et al, 19861. Since highway maintenance work in Minnesota has not employed coal tar products for 50 years, HMW exposure to carcinogenic PAHs of pitch was probably much lower than the roofers' exposure.…”

Section: It Has Recentlymentioning

confidence: 99%

Minnesota highway maintenance worker study: Cancer mortality

Bender

Parker

Johnson

et al. 1989

American J Industrial Med

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Highway maintenance workers (HMWs) have been exposed to a broad range of potentially toxic substances, including diesel fuels and exhaust, asphalts and tars, herbicides, gasoline, polynuclear aromatic hydrocarbons, benzene, and lead. The number of current and former state, county, and municipal HMWs in the United States exceeds 500,000, yet the health risks of this occupation had never been studied. To fill this void and to respond to the public perception that Minnesota HMWs were at high risk of developing leukemia, an occupational cohort mortality study was conducted of Minnesota HMWs employed between 1945 and 1984. Leukemia mortality in HMWs with 30-39 years of work (standardized mortality ratio [SMR] = 425; 95% confidence interval [CI] = 171-876) and urologic cancer mortality in HMWs with 40-49 year latency (SMR = 292; CI = 117-602) were significantly elevated. The extent to which these and other findings were directly related to work exposures is unknown. Further investigations to resolve the significance of the risks associated with the HMW occupation are currently underway.

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Section: It Has Recentlymentioning

confidence: 99%

Minnesota highway maintenance worker study: Cancer mortality

Bender

Parker

Johnson

et al. 1989

American J Industrial Med

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“…Most of these samples, analyzed by fairly sensitive and specific methods, contained less than 50 mg/kg total PAHs. Several samples analyzed by Wallcave et al (1971) [29] by less sophisticated analytical methods contained similar or lower concentrations of total PAHs. However, one sample contained nearly 300 mg/kg total PAHs.…”

Section: Asphaltmentioning

confidence: 99%

Potential Non-Traditional Uses of By-Product E&P Produced Sulfur in Kazakhstan

Beall

Neff

2005

All Days

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“…IARC classified carcinogenic PAHs in Group 1 (IARC, 1987). Petroleum asphalts induced various skin tumors in mice (Wallcave et al, 1971), and data in the literature suggested increased lung cancer incidence among workers exposed to hot asphalt fumes (Decouflé et al, 1977;Menck & Henderson, 1976;Milham, 1982). Other important carcinogenic agents in the working environment of road pavers are benzene (IARC Group 1), crude oils (IARC Group 1), and diesel exhaust gases (IARC Group 2A) (IARC, 1987).…”

mentioning

confidence: 97%

Working Condition-Related Improvement in Genotoxicological Parameters of Hungarian Road Pavers

Major

Jakab

Tompa

2001

Journal of Toxicology and Environmental Health, Part A

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Multiple-endpoint follow-up genotoxicology monitoring was performed in a group of 22 Hungarian road pavers between 1996 and 1999. The studied endpoints were the determination of structural and numeric chromosome aberration (CA), sister chromatid exchange (SCE), high-frequency SCE and HPRT mutation frequencies, and ultraviolet (UV)-light-induced unscheduled DNA synthesis in peripheral blood lymphocytes (PBLs). The workers (8 hand pavers and 14 finishers, mean age 37 yr) used tar-free asphalt. The results were compared with those of 6 work-site controls (35 yr), 101 historical controls (38 yr), and 87 industrial controls (38 yr). The most marked changes were found in the CA frequencies. In the control, the mean CA frequency was 1.6%. In the first study, increased CA frequencies were found in the donors that either had been exposed to hot asphalt fumes or had cleaned the equipment with crude oil. The mean CA frequency of the 14 finishers working in closed cabins was 3.67% in 1996. The increased CA frequency was attributed to the high level of hot asphalt fumes due to insufficient ventilation. By 1999 the mean CA frequency decreased to 1.23%. For the 8 hand pavers working in open air the mean CA frequency was 3.6% in 1996. The obtained data suggested that the increase in CA frequencies was due to the use of petroleum and crude oil; therefore, these substances were replaced with harmless detergents. By 1999 the mean CA frequency decreased to 1%. In finishers the mean CA frequency returned to the control level 1 yr later (1999) than in the case of hand pavers. The chromosome-type aberrations remained predominant during the follow-up. The individual variations observed were attributed to smoking and inadequate personal protection. The obtained results suggest that the use of tar-free asphalt and harmless detergents with adequate personal protection does not increase the frequencies of the genotoxicological parameters compared to controls. Consequently, an improvement in working conditions can prevent further exposures and thus decrease the cancer risk of road pavers.

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Skin tumorigenesis in mice by petroleum asphalts and coal-tar pitches of known polynuclear aromatic hydrocarbon content

Cited by 59 publications

References 5 publications

Minnesota highway maintenance worker study: Cancer mortality

Minnesota highway maintenance worker study: Cancer mortality

Potential Non-Traditional Uses of By-Product E&P Produced Sulfur in Kazakhstan

Working Condition-Related Improvement in Genotoxicological Parameters of Hungarian Road Pavers

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