SkQ1 regulates expression of Nrf2, ARE-controlled genes encoding antioxidant enzymes, and their activity in cerebral cortex under oxidative stress

Vnukov, V. V.; Gutsenko, O. I.; Milyutina, N. P.; Корниенко, И. В.; Ananyan, A. A.; Plotnikov, Andrey A.; Panina, Svetlana

doi:10.1134/s0006297917080090

Cited by 28 publications

(16 citation statements)

References 36 publications

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“…A huge body of evidence revealed that the antioxidant SOD is activated by the Nrf2 pathway against different conditions of oxidative stress (Milani, Ambrosi, Gammoh, Blandini, & Cereda, 2013; Vnukov et al, 2017). Nrf2 is a vital transcription factor commonly expressed in organs with high oxygen consumption.…”

Section: Discussionmentioning

confidence: 99%

Paeonol protects against testicular ischaemia‐reperfusion injury in rats through inhibition of oxidative stress and inflammation

et al. 2020

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Ischaemia‐reperfusion (IR) is the most common form of testicular injury that results in oxidative damage and inflammation ending by subinfertility. Paeonol, a natural phenolic compound, exhibits antioxidant and anti‐inflammatory effects. Thus, the present study investigated the role of paeonol in rat testicular IR injury. Thirty adult Wistar rats were randomly divided into five groups; sham, sham treated with paeonol, IR injury, and IR pre‐treated with paeonol at low and high doses. Serum testosterone and testicular levels of malondialdehyde and reduced glutathione (GSH) besides superoxide dismutase (SOD) activity were determined. Gene quantifications for tumour necrosis factor‐α (TNF‐α), hypoxia‐inducible factor‐1α (HIF‐1α) and heat shock protein 70 (HSP70) were also assessed. Histopathological pictures and the immunohistochemical expression of testicular nuclear factor erythroid 2‐related factor 2 (Nrf2), interleukin‐1β (IL‐1β) and interleukin‐6 (IL‐6) were shown. Pre‐treatment with paeonol prevented the drop in serum testosterone, alongside with improvement of testicular malondialdehyde and GSH levels plus SOD activity. Paeonol regained the normal spermatogenesis with prevention of IR‐induced increase in TNF‐α, HIF‐1α and HSP70 gene expression besides IL‐1β and IL‐6 immunostaining and reduction in Nrf2 protein expression. Paeonol exerted a dose‐dependent beneficial effect on testicular IR injury. This effect was achieved by its antioxidant and anti‐inflammatory effects.

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Section: Discussionmentioning

confidence: 99%

Paeonol protects against testicular ischaemia‐reperfusion injury in rats through inhibition of oxidative stress and inflammation

et al. 2020

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“…HO-1, NQO1, and SOD are the antioxidant genes regulated by Nrf2 binding to antioxidant response elements. 28,29 These genes play important roles in response to oxidative stress and have cytoprotective effects. 30 HO-1 can catalyze the degradation of heme, and the degradation products also have antioxidant functions.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Naringin on Cigarette Smoke-Induced Dynamic Changes in Oxidation/Antioxidant System in Lung of Mice

Chen

Xiao

et al. 2020

Natural Product Communications

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Naringin possesses strong antioxidative activity and can protect against some respiratory diseases. Oxidative stress is thought to be a major factor in the development of many tobacco-caused diseases. The nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway plays a critical role in the regulation of oxidative stress. The dynamic changes in the antioxidant system in the lung that are induced by cigarette smoke (CS) are not well investigated, and how naringin affects these changes remains unknown. This study aimed to investigate the dynamic changes between the oxidation and antioxidant systems resulting from CS exposure and the effects of naringin on these changes in mice. Mice were chronically exposed to CS for 30 days. The levels of malondialdehyde (MDA), glutathione (GSH), interleukin (IL)-6, and tumor necrosis factor-alpha (TNF-α); the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px); and the expressions of Nrf2, heme oxygenase-1 (HO-1), and nicotinamide adenine dinucleotide phosphate quinone dehydrogenase 1 (NQO1) in lung tissue were measured on days 2, 7, and 30. The levels of MDA, GSH, IL-6, and TNF-α in the lung were found to increase throughout the exposure. SOD and GSH-Px activities showed an increase on day 2 and a decrease on days 7 and 30. The messenger ribonucleic acid expressions of Nrf2, HO-1, and NQO1 were elevated on day 2 and decreased on day 7; Nrf2 and HO-1 expressions were continually decreased, but NQO1 expression was increased again, on day 30. Naringin restored the levels of these biochemical indices to normal throughout the experiment, suggesting that naringin protected against the CS-induced oxidative damage by suppressing the increase of antioxidants resulting from the early stage of CS exposure, as well as inhibiting the depletion of antioxidants due to long-term oxidative stress. Naringin also suppressed lung inflammation by inhibiting IL-6 and TNF-α. These results indicate that naringin possesses a powerful ability to maintain the balance of the oxidation/antioxidant system in the lung when subjected to CS exposure, probably by regulating the Nrf2 signaling pathway.

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“…The Nrf2 pathway has been identified to be the pivotal regulator for oxidative stress, which participates in transcription of many enzymes, such as SOD and GPX (Vnukov et al 2017). To explore the exact mechanism of Sch B neuroprotective effect in the anxiety disorder, the western blot method was used to verify the conjecture that whether Sch B altered expression of molecular targets commonly associated with oxidative stress.…”

Section: Effect Of Sch B On the Nrf2/keap1 Expression In Stress-inducmentioning

confidence: 99%

Schisandrin B alleviates acute oxidative stress via modulation of the Nrf2/Keap1-mediated antioxidant pathway

Ying

Yao

et al. 2019

Appl. Physiol. Nutr. Metab.

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Schisandrin B (Sch B), one of Fructus Schisandrae's main effective components, protects neurons from oxidative stress in the central nervous system. Here we investigated the neuroprotective effect of Sch B in the acute oxidative stress damage and attempted to define the possible mechanisms. From the elevated plus maze (EPM) and open field test (OFT), we found that forcing swimming, an acute stressor, significantly induced anxiety-like behavior which was alleviated by Sch B (p.o.) treatment. In addition, the Sch B treatment suppressed toxicity, malondialdehyde (MDA) and reactive oxygen species (ROS), an important factor for neuron damage. The antioxidant molecules under the control of Nrf2 pathway, such as superoxide dismutase (SOD) and glutathione (GSH), were significantly increased by Sch B treatment. Moreover, a higher percentage of intact cells in the amygdala further verified the neuroprotective effect of Sch B in Nissl staining. Several proteins such as Nrf2 and its endogenous inhibitor Keap1, were abnormal expressed in force swimming mice but were significantly reversed by Sch B treatment. Herein, our results suggested that Sch B may be a potential therapeutic agent against anxiety disease that is associated with oxidative stress. The possible mechanism is attributed to its neuroprotection through enhancing antioxidant effect.

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SkQ1 regulates expression of Nrf2, ARE-controlled genes encoding antioxidant enzymes, and their activity in cerebral cortex under oxidative stress

Cited by 28 publications

References 36 publications

Paeonol protects against testicular ischaemia‐reperfusion injury in rats through inhibition of oxidative stress and inflammation

Paeonol protects against testicular ischaemia‐reperfusion injury in rats through inhibition of oxidative stress and inflammation

The Effects of Naringin on Cigarette Smoke-Induced Dynamic Changes in Oxidation/Antioxidant System in Lung of Mice

Schisandrin B alleviates acute oxidative stress via modulation of the Nrf2/Keap1-mediated antioxidant pathway

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