Skull metastasis from papillary thyroid carcinoma accompanied by neurofibromatosis type 1 and pheochromocytoma: report of a case

Abstract

We report here a 74-year-old woman with a skull metastasis from papillary thyroid carcinoma (PTC). In her medical history, she was diagnosed with neurofibromatosis type 1 (NF1) at age 28 years, and she underwent thyroidectomy for PTC at age 52 years and adrenectomy for pheochromocytoma (PC) at age 58 years. She was admitted to our hospital with an increased mass in the forehead. Head computed tomography (CT) showed an expansive, osteolytic, and solid tumor extending from the dura mater into the subcutis, destroying part of the frontal bone. Head magnetic resonance imaging (MRI) revealed that the tumor was chiefly extradural but partially invaded the dura mater. Cerebral angiography showed that the tumor was fed from a branch of the external carotid artery. She underwent surgery, and histological examination revealed that the skull tumor was a metastasis from PTC, indicating that skull metastasis occurred 23 years after curative surgery for PTC. The patient also underwent adjuvant radioiodine therapy. As little is known about skull metastases from PTC, we discuss its characteristics and the extremely rare combined occurrence of PC and PTC in an NF1 patient.

Coexistence of paraganglioma/pheochromocytoma and papillary thyroid carcinoma: a four-case series analysis

“…On the contrary, the association of papillary thyroid carcinoma (PTC), the most common thyroid carcinoma, arising from the follicular cells, with single or multiple PGL/PHEO was reported [1][2][3][4][5][6][7][8] in only a few cases (Table 1). Whether this association is coincidental or has a genetic underlying relationship remains to be elucidated.…”

Neurofibroma adjacent to the thyroid gland and a thyroid papillary carcinoma in a patient with neurofibromatosis type 1: Report of a case

“…Nakamura et al 3 reported a case of NF type 1 associated with a pheochromocytoma and thyroid papillary carcinoma in a 58-year old woman. Another case was reported by Hashiba et al 4 with skull metastasis from thyroid papillary carcinoma in a 74-year-old woman with NF type 1. The medical history of their patient included a total thyroidectomy for papillary thyroid carcinoma at age 52 and a right adrenalectomy for pheochromocytoma at age 58, and she was alive without any evidence of recurrence or metastasis at 3.5 years when this report was written.…”

“…1,2 Thyroid carcinomas including papillary carcinoma are very rare in NF type 1. [3][4][5] Another rare condition is a neurofi broma in thyroid tissue mimicking a nonfunctional thyroid nodule. [6][7][8][9] This report presents the case of a neurofi broma adherent to the thyroid gland with thyroid papillary carcinoma in a 26-year-old woman with NF type 1.…”

Coexistence of Gastrointestinal Stromal Tumors (GISTs) and Pheochromocytoma in Three Cases of Neurofibromatosis Type 1 (NF1) with a Review of the Literature

“…NF1 has been reported to be associated with a number of malignancies. However, the occurence of papillary thyroid carcinoma associated with NF1 is very rare, with only four cases having been published in the English literature (24)(25)(26)(27). Furthermore, the coexistence of NF1, GIST, pheochromocytoma and papillary thyroid carcinoma has not been previously reported.…”