Slc43a3 is a regulator of free fatty acid flux

Hasbargen, Kathrin; Shen, Wen-Jun; Zhang, Yiqiang; Hou, Xiaoming; Wang, Wei; Shuo, Qui; Bernlohr, David A.; Azhar, Salman; Kraemer, Fredric B.

doi:10.1194/jlr.ra119000294

Cited by 17 publications

(15 citation statements)

References 38 publications

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“…Interestingly, SLC43A3, the most heavily weighted among the seven SLC genes, has previously been reported to be associated with purine and fatty acid metabolism. 39,40 These results further confirmed that our classification based on the 7-SLC expression pattern can distinguish between two intrinsically different sets of cell subpopulations.…”

Section: Differential Transcriptome Regulation and Metabolic States I...supporting

confidence: 78%

Multi‐omics analysis reveals the association between specific solute carrier proteins gene expression patterns and the immune suppressive microenvironment in glioma

Wu,

Jiang,

Zhu

et al. 2024

J Cellular Molecular Medi

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Glioma is the most prevalent malignant brain tumour. Currently, reshaping its tumour microenvironment has emerged as an appealing strategy to enhance therapeutic efficacy. As the largest group of transmembrane transport proteins, solute carrier proteins (SLCs) are responsible for the transmembrane transport of various metabolites and ions. They play a crucial role in regulating the metabolism and functions of malignant cells and immune cells within the tumour microenvironment, making them a promising target in cancer therapy. Through multidimensional data analysis and experimental validation, we investigated the genetic landscape of SLCs in glioma. We established a classification system comprising 7‐SLCs to predict the prognosis of glioma patients and their potential responses to immunotherapy and chemotherapy. Our findings unveiled specific SLC expression patterns and their correlation with the immune‐suppressive microenvironment and metabolic status. The 7‐SLC classification system was validated in distinguishing subgroups within the microenvironment, specifically identifying subsets involving malignant cells and tumour‐associated macrophages. Furthermore, the orphan protein SLC43A3, a core member of the 7‐SLC classification system, was identified as a key facilitator of tumour cell proliferation and migration, suggesting its potential as a novel target for cancer therapy.

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Section: Differential Transcriptome Regulation and Metabolic States I...supporting

confidence: 78%

Multi‐omics analysis reveals the association between specific solute carrier proteins gene expression patterns and the immune suppressive microenvironment in glioma

Wu,

Jiang,

Zhu

et al. 2024

J Cellular Molecular Medi

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“…In acute hepatotoxicity, mitochondrial SH3BP5, as the target of JNK, maintains its activation by promoting the production of reactive oxygen species [43]. The overexpression of Slc43a3 reduces FA uptake in differentiated OP9 cells and leads to reduced lipid droplet accumulation [44]. These results show that the seven genes play an important role in a variety of complex diseases.…”

Section: Discussionmentioning

confidence: 92%

Single-Cell Sequencing Revealed Pivotal Genes Related to Prognosis of Myocardial Infarction Patients

Zhou

Wen

et al. 2022

Computational and Mathematical Methods in Medicine

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Objectives. Myocardial infarction (MI) is a common cardiovascular disease. Histopathology is a main molecular characteristic of MI, but often, differences between various cell subsets have been neglected. Under this premise, MI-related molecular biomarkers were screened using single-cell sequencing. Methods. This work examined immune cell abundance in normal and MI samples from GSE109048 and determined differences in the activated mast cells and activated CD4 memory T cells, resting mast cells. Weighted gene coexpression network analysis (WGCNA) demonstrated that activated CD4 memory T cells were the most closely related to the turquoise module, and 10 hub genes were screened. Single-cell sequencing data (scRNA-seq) of MI were examined. We used t -distributed stochastic neighbor embedding ( t -SNE) for cell clustering. Results. We obtained 8 cell subpopulations, each of which had different marker genes. 7 out of the 10 hub genes were detected by single-cell sequencing analysis. The expression quantity and proportion of the 7 genes were different in 8 cell clusters. Conclusion. In general, our study revealed the immune characteristics and determined 7 prognostic markers for MI at the single-cell level, providing a new understanding of the molecular characteristics and mechanism of MI.

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“…Alternative direct methods based on the same mechanistic principle include the use of radiolabelled FAs. Nevertheless, and despite overcoming the signal attenuation, the use of radiolabelled compounds needs to be carefully considered, since it requires the use of special infrastructure and qualified personnel [ 144 , 145 ].…”

Section: Liver-specific Toxicity In Vitro Methodsmentioning

confidence: 99%

In Vitro Liver Toxicity Testing of Chemicals: A Pragmatic Approach

Tabernilla

Rodrigues

Pieters

et al. 2021

IJMS

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The liver is among the most frequently targeted organs by noxious chemicals of diverse nature. Liver toxicity testing using laboratory animals not only raises serious ethical questions, but is also rather poorly predictive of human safety towards chemicals. Increasing attention is, therefore, being paid to the development of non-animal and human-based testing schemes, which rely to a great extent on in vitro methodology. The present paper proposes a rationalized tiered in vitro testing strategy to detect liver toxicity triggered by chemicals, in which the first tier is focused on assessing general cytotoxicity, while the second tier is aimed at identifying liver-specific toxicity as such. A state-of-the-art overview is provided of the most commonly used in vitro assays that can be used in both tiers. Advantages and disadvantages of each assay as well as overall practical considerations are discussed.

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Slc43a3 is a regulator of free fatty acid flux

Cited by 17 publications

References 38 publications

Multi‐omics analysis reveals the association between specific solute carrier proteins gene expression patterns and the immune suppressive microenvironment in glioma

Multi‐omics analysis reveals the association between specific solute carrier proteins gene expression patterns and the immune suppressive microenvironment in glioma

Single-Cell Sequencing Revealed Pivotal Genes Related to Prognosis of Myocardial Infarction Patients

In Vitro Liver Toxicity Testing of Chemicals: A Pragmatic Approach

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