SLC6A14 and 5-HTR2C polymorphisms are associated with food intake and nutritional status in children

Miranda, Raquel; Vetter, Silvia B.; Genro, Júlia Pasqualini; Campagnolo, Paula Dal Bó; Mattevi, Vanessa Suñé; Vítolo, Márcia Regina; Almeida, Silvana

doi:10.1016/j.clinbiochem.2015.07.003

Cited by 16 publications

(11 citation statements)

References 29 publications

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“…Ethnicity was defined by the interviewer by skin color (i.e., whites and non-whites). More details of the traits studied are described elsewhere ( Galvão, 2012 ; Louzada et al , 2012 ; Fontana et al , 2015 ; Miranda et al , 2015 ). This study was conducted according to the guidelines of the Declaration of Helsinki.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of association of DRD2 TaqIA and -141C InsDel polymorphisms with food intake and anthropometric data in children at the first stages of development

et al. 2018

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The reward sensation after food intake may be different between individuals and variants in genes related to the dopaminergic system may indicate a different response in people exposed to the same environmental factors. This study investigated the association of TaqIA (rs1800497) and -141C InsDel (rs1799732) variants in DRD2/ANKK1 gene with food intake and adiposity parameters in a cohort of children. The sample consisted of 270 children followed until 7 to 8 years old. DNA was extracted from blood and polymorphisms were detected by PCR-RFLP analysis. Food intake and nutritional status were compared among individuals with different SNP genotypes. Children carrying the A1 allele (TaqIA) had higher energy of lipid dense foods (LDF) when compared with A2/A2 homozygous children at 7 to 8 years old (GLM p=0.004; Mann Whitney p=0.005). No association was detected with -141C Ins/Del polymorphism. To our knowledge, this is the first association study of the DRD2 TaqIA and -141C Ins/Del polymorphism with food intake and anthropometric parameters in children. DRD2 TaqIA polymorphism has been associated with a reduction in D2 dopamine receptor availability. Therefore, the differences observed in LDF intake in our sample may occur as an effort to compensate the hypodopaminergic functioning.

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Section: Methodsmentioning

confidence: 99%

Evaluation of association of DRD2 TaqIA and -141C InsDel polymorphisms with food intake and anthropometric data in children at the first stages of development

et al. 2018

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“…In fact, it is not even known what these specific SNPs do to the expression of the transporter. The transporter is also linked to obesity [31-33]; again, nothing is known on the molecular basis of the connection. Similarly, the transporter is also associated with inflammatory bowel disease; the expression of the transporter is induced several-fold in the colon of patients with ulcerative colitis [34, 35].…”

Section: Slc6a14 and Slc6a19mentioning

confidence: 99%

Glutamine transporters in mammalian cells and their functions in physiology and cancer

Bhutia

Ganapathy

2016

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

257

226

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The SLC (solute carrier)-type transporters (∼400 in number) in mammalian cells consist of 52 distinct gene families, grouped solely based on the amino acid sequence (primary structure) of the transporter proteins and not on their transport function. Among them are the transporters for amino acids. Fourteen of them, capable of transporting glutamine across the plasma membrane, are found in four families: SLC1, SLC6, SLC7, and SLC38. However, it is generally thought that the members of the SLC38 family are the principal transporters for glutamine. Some of the glutamine transporters are obligatory exchangers whereas some function as active transporters in one direction. While most glutamine transporters mediate the influx of the amino acid into cells, some actually mediate the efflux of the amino acid out of the cells. Glutamine transporters play important roles in a variety of tissues, including the liver, brain, kidney, and placenta, as clearly evident from the biological and biochemical phenotypes resulting from the deletion of specific glutamine transporters in mice. Owing to the obligatory role of glutamine in growth and proliferation of tumor cells, there is increasing attention on glutamine transporters in cancer biology as potential drug targets for cancer treatment. Selective blockers of certain glutamine transporters might be effective in preventing the entry of glutamine and other important amino acids into tumor cells, thus essentially starving these cells to death. This could represent the beginning of a new era in the discovery of novel anticancer drugs with a previously unexplored mode of action.

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“…Durand et al also identified an association between SLC6A14 rs2071877 genetic variant and obesity in a French cohort [ 71 ]. This variant has also been associated with sum of triceps and subscapular skinfolds thickness, an objective measure of adiposity, in boys 7–8 of age [ 70 ]. Finally, Miranda et al also found evidences of associations between two other genetic variants, rs2312054 and rs12391221, and several parameters used to assess the food intake in children [ 70 ].…”

Section: Slc6a14 In Non-cf Diseasesmentioning

confidence: 99%

Update on SLC6A14 in lung and gastrointestinal physiology and physiopathology: focus on cystic fibrosis

Ruffin

Mercier

Calmel

et al. 2020

Cell. Mol. Life Sci.

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The solute carrier family 6 member 14 (SLC6A14) protein imports and concentrates all neutral amino acids as well as the two cationic acids lysine and arginine into the cytoplasm of different cell types. Primarily described as involved in several cancer and colonic diseases physiopathological mechanisms, the SLC6A14 gene has been more recently identified as a genetic modifier of cystic fibrosis (CF) disease severity. It was indeed shown to have a pleiotropic effect, modulating meconium ileus occurrence, lung disease severity, and precocity of P. aeruginosa airway infection. The biological mechanisms explaining the impact of SLC6A14 on intestinal and lung phenotypes of CF patients are starting to be elucidated. This review focuses on SLC6A14 in lung and gastrointestinal physiology and physiopathology, especially its involvement in the pathophysiology of CF disease.

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SLC6A14 and 5-HTR2C polymorphisms are associated with food intake and nutritional status in children

Cited by 16 publications

References 29 publications

Evaluation of association of DRD2 TaqIA and -141C InsDel polymorphisms with food intake and anthropometric data in children at the first stages of development

Evaluation of association of DRD2 TaqIA and -141C InsDel polymorphisms with food intake and anthropometric data in children at the first stages of development

Glutamine transporters in mammalian cells and their functions in physiology and cancer

Update on SLC6A14 in lung and gastrointestinal physiology and physiopathology: focus on cystic fibrosis

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