SLE autoantibodies are well recognized by peroxynitrite-modified-HSA: Its implications in the pathogenesis of SLE

Arif, Zarina; Neelofar, Km; Tarannum, Akhlas; Arfat, Mir Yasir; Ahmad, Shafeeque; Zaman, Asif; Khan, Mohd Adnan; Badar, Asim; Islam, Shireen Naaz; Iqubal, Mohammad Arif

doi:10.1016/j.ijbiomac.2017.08.122

Cited by 9 publications

(7 citation statements)

References 46 publications

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“…These results indicate that peroxynitrite-modified biomolecules play a role in autoantibody production in SLE. In addition, Arif et al [125] and Ahmad et al [126] confirmed that anti-dsDNA-positive IgG obtained from SLE sera show a binding affinity with peroxynitrite-modified human serum albumin. These data also suggest compellingly that antibodies against peroxynitrite-modified biomolecules are implicated in lupus pathogenesis (right panel of Figure 5).…”

Section: Molecular Basis Of Oxidative and Nitrosative Stresses In mentioning

confidence: 96%

Molecular and Cellular Bases of Immunosenescence, Inflammation, and Cardiovascular Complications Mimicking “Inflammaging” in Patients with Systemic Lupus Erythematosus

Tsai

Shen

Liao

et al. 2019

IJMS

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Systemic lupus erythematosus (SLE) is an archetype of systemic autoimmune disease, characterized by the presence of diverse autoantibodies and chronic inflammation. There are multiple factors involved in lupus pathogenesis, including genetic/epigenetic predisposition, sexual hormone imbalance, environmental stimulants, mental/psychological stresses, and undefined events. Recently, many authors noted that “inflammaging”, consisting of immunosenescence and inflammation, is a common feature in aging people and patients with SLE. It is conceivable that chronic oxidative stresses originating from mitochondrial dysfunction, defective bioenergetics, abnormal immunometabolism, and premature telomere erosion may accelerate immune cell senescence in patients with SLE. The mitochondrial dysfunctions in SLE have been extensively investigated in recent years. The molecular basis of normoglycemic metabolic syndrome has been found to be relevant to the production of advanced glycosylated and nitrosative end products. Besides, immunosenescence, autoimmunity, endothelial cell damage, and decreased tissue regeneration could be the results of premature telomere erosion in patients with SLE. Herein, the molecular and cellular bases of inflammaging and cardiovascular complications in SLE patients will be extensively reviewed from the aspects of mitochondrial dysfunctions, abnormal bioenergetics/immunometabolism, and telomere/telomerase disequilibrium.

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Section: Molecular Basis Of Oxidative and Nitrosative Stresses In mentioning

confidence: 96%

Molecular and Cellular Bases of Immunosenescence, Inflammation, and Cardiovascular Complications Mimicking “Inflammaging” in Patients with Systemic Lupus Erythematosus

Tsai

Shen

Liao

et al. 2019

IJMS

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“…For decades, researchers have identified a pivotal role of ROS and oxidative post-translational modifications (oxPTMs) in autoimmunity [43]. Chronic inflammation and chronic ROS release modified antigens, leading to auto-antibodies and auto-reactive T cells that are observed in numerous diseases, including rheumatoid arthritis, systemic lupus erythematosus, and diabetes [44][45][46][47][48], partly in a neoepitope-like fashion [49,50]. Mechanistically, oxPTMs have been ascribed a function similar to damageassociated molecular patterns (DAMPs) [51], providing pro-inflammatory stimuli in in professional antigen-presenting cells (APCs), and are decisive for the balance between antigen tolerance and immunity.…”

Section: Reactive Oxygen and Nitrogen Speciesmentioning

confidence: 99%

ROS Cocktails as an Adjuvant for Personalized Antitumor Vaccination?

Clemen

Bekeschus

2021

Vaccines

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Cancer is the second leading cause of death worldwide. Today, the critical role of the immune system in tumor control is undisputed. Checkpoint antibody immunotherapy augments existing antitumor T cell activity with durable clinical responses in many tumor entities. Despite the presence of tumor-associated antigens and neoantigens, many patients have an insufficient repertoires of antitumor T cells. Autologous tumor vaccinations aim at alleviating this defect, but clinical success is modest. Loading tumor material into autologous dendritic cells followed by their laboratory expansion and therapeutic vaccination is promising, both conceptually and clinically. However, this process is laborious, time-consuming, costly, and hence less likely to solve the global cancer crisis. Therefore, it is proposed to re-focus on personalized anticancer vaccinations to enhance the immunogenicity of autologous therapeutic tumor vaccines. Recent work re-established the idea of using the alarming agents of the immune system, oxidative modifications, as an intrinsic adjuvant to broaden the antitumor T cell receptor repertoire in cancer patients. The key novelty is the use of gas plasma, a multi-reactive oxygen and nitrogen species-generating technology, for diversifying oxidative protein modifications in a, so far, unparalleled manner. This significant innovation has been successfully used in proof-of-concept studies and awaits broader recognition and implementation to explore its chances and limitations of providing affordable personalized anticancer vaccines in the future. Such multidisciplinary advance is timely, as the current COVID-19 crisis is inexorably reflecting the utmost importance of innovative and effective vaccinations in modern times.

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“…80 It may also be speculated that OONOmodified-HSA generate neo-epitopes produced by OONOmodification that creates biophysical and biochemical changes in the protein, which was confirmed by the generation of highly specific antibodies in an experimental animal study. 103 Such antibodies against modified/damaged albumin have been reported in various diseases like diabetes mellitus, systemic lupus erythematosus, and other autoimmune diseases and in cancer. 103 Many impairments in the antioxidant properties of albumin after glycation and/or oxidation and/or nitration are manifested and they are important in the pathogenesis of many diseases.…”

Section: Albumin Modification By Reactive Species and Dicarbonyls Andmentioning

confidence: 99%

“…103 Such antibodies against modified/damaged albumin have been reported in various diseases like diabetes mellitus, systemic lupus erythematosus, and other autoimmune diseases and in cancer. 103 Many impairments in the antioxidant properties of albumin after glycation and/or oxidation and/or nitration are manifested and they are important in the pathogenesis of many diseases. 104,105 OONOproduced during inflammatory conditions causes structural changes in albumin that has been trapped in synovial cells.…”

Section: Albumin Modification By Reactive Species and Dicarbonyls Andmentioning

confidence: 99%

Nitroxidized-Albumin Advanced Glycation End Product and Rheumatoid Arthritis

et al. 2019

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SLE autoantibodies are well recognized by peroxynitrite-modified-HSA: Its implications in the pathogenesis of SLE

Cited by 9 publications

References 46 publications

Molecular and Cellular Bases of Immunosenescence, Inflammation, and Cardiovascular Complications Mimicking “Inflammaging” in Patients with Systemic Lupus Erythematosus

Molecular and Cellular Bases of Immunosenescence, Inflammation, and Cardiovascular Complications Mimicking “Inflammaging” in Patients with Systemic Lupus Erythematosus

ROS Cocktails as an Adjuvant for Personalized Antitumor Vaccination?

Nitroxidized-Albumin Advanced Glycation End Product and Rheumatoid Arthritis

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