SLE Developing in a Follow-Up Patient of Kikuchi’s Disease: A Rare Disorder

Patra, Anupam; Bhattacharya, Sujit

doi:10.7860/jcdr/2013/5017.2904

Cited by 17 publications

(19 citation statements)

References 7 publications

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“…It is suggested that viral agents, hyperimmune reactions triggered by different antigens and cellular apoptosis are involved in its etiology [10]. Toxoplasma and other bacteria like Yersinia, Bartonella and Brucella have also been implicated as possible triggering agents [11]. The viral hypothesis has been subject of intense research, in fact, it has been emphasized the role of Epstein Barr virus, cytomegalovirus and human herpes virus 6 in eliciting a hyperimmune reaction lead by cytotoxic lymphocytes T towards infected lymphocytes [10,12].…”

Section: Discussionmentioning

confidence: 99%

“…Associations with other autoimmune diseases have been also reported such as Hashimoto's thyroiditis, polymiosytis, mixed connective tissue disease, Still's disease and autoimmune hepatitis [10]. It has been suggested that ANA test should be performed in patients with suspected Kikuchi's syndrome in order to exclude SLE [11]. Clinically the presentation of KFD and TB and SLE may overlap and it may be difficult to segregate them.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Kikuchi – Fujimoto Disease. Case report and a brief review of the literature

Valdebran¹,

Marte²,

Charles-Ramirez³

et al. 2014

Our Dermatol Online

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Kikuchi – Fujimoto Disease. Case report and a brief review of the literature

Valdebran¹,

Marte²,

Charles-Ramirez³

et al. 2014

Our Dermatol Online

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“…However, a follow-up of these patients is absolutely necessary as these patients are known to have recurrences or known to develop Lupus. [9] …”

Section: Discussionmentioning

confidence: 99%

Kikuchis lymphadenitis: Is biopsy necessary in managing these patients

Anantharamaiah

Arokiyaswamy

Prasad

2015

Int J Med Public Health

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Kikuchis lymphadenitis: Is biopsy necessary in managing these patientsKikuchis-Fujimoto's is a benign, self-limiting, cervical lymphadenitis, fi ne-needle aspiration cytology (FNAC) plays a very important role in the diagnosis and management of these patients. We present a case of 30-year-old female presenting with supraclavicular lymphadenopathy and fever, diagnosed as Kikuchis-Fujimoto's lymphadenitis on FNAC with no recurrence or development of Lupus lymphadenitis even after 1-year of follow-up. Although Kikuchis-Fujimoto's is a rare cause of lymphadenopathy, FNAC is an important tool in diagnosing this entity and differentiating from tubercular lymphadenitis and Lupus adenitis. Presence of cresentric nucleated histiocytes engulfed karryorrhectic debris and monocytoid cells aids in the diagnosing. A defi nitive diagnosis made on FNAC can avoid biopsy and unnecessary diagnostic and therapeutic interventions in these patients. However, a look out for recurrence and development of Lupus with regular followup and serological examination is imperative.Key words: Fine-needle aspiration cytology, kikuchis-fujimoto's, lupus adenitis, tubercular adenitis INTRODUCTIONKikuchis-Fujimoto's disease (KFD) or histiocytic necrotising lymphadenitis was fi rst described by Kikuchis, simultaneously by Fujimoto's et al. in 1972. [1,2] Since then, numerous cases have been reported in both Asian and western population. Though a self-limiting disease that resolves on its own within few weeks and months, it is known to recur in 3-4% of cases. [3] Though fi ne-needle aspiration cytology (FNAC) is diagnostic in most of these cases, histopathological examination of the excised node is usually done to confi rm the diagnosis and differentiate from other causes of adenitis. CASE REPORTA 31-year-old female presented with fever (low grade, Intermittent), headache, edema, weight loss and pain in the right supraclavicular region of 3 month's duration. There was no history of cough with expectoration/weight loss/skin rash/joint pain or any other swellings in the body. On examination, she was febrile, with multiple nodules in right supraclavicular region. A diagnosis of viral fever with supraclavicular lymphadenopathy and was made, and she was treated symptomatically. Since her symptoms did not subside even after 1 week of treatment, the presumptive diagnosis of tubercular lymphadenitis was made, and laboratory workup was suggested. All her biochemical and hematological investigations were normal except an increase in erythrocyte sedimentation rate (80 mm at the end of 1 st h). Antinuclear antibody test was negative.An ultrasonography of right supraclavicular region revealed multiple nodes in upper and middle jugular areas largest measuring 1.4 cm across. A diagnosis of reactive lymph node enlargement was given.Fine-needle aspiration cytology of the node was highly cellular with a heterogeneous population of lymphocytes, histiocytes, cresentric nucleated histiocytes [ Figure 1] (histiocyte with cresentric nucleus and eosinophilic inclusions in ...

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“…There have been reports of success in the treatment of recurrent disease of Kikuchi-Fujimoto with hydroxychloroquine [36]. Affected patients should be followed for a few years because they may be affected of LES and relapses of the disease of Kikuchi-Fujimoto are applicants for several years, after the first episode of disease [22][23][24][25][26].…”

Section: Treatmentmentioning

confidence: 99%

“…Some patients initially diagnosed with Kikuchi disease presented later systemic lupus erythematosus (SLE) [8,23]. The FAN should be performed in patients with suspicion of Kikuchi disease that have features suggestive of LES to delete such a diagnosis.…”

Section: Laboratory Testsmentioning

confidence: 99%

Kikuchi-Fujimoto disease: case report and review

Araújo‐Filho¹,

Freire²,

AraÃojo-Neto³

et al. 2017

Int J Med Rev Case Rep

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Objective:The development of associated febrile to lymphadenomegaly leads to several diagnostic hypotheses, among them the Kikushi-Fujimoto disease.Method:This review was set up by searching PubMed/Medline, Web of Science and Scopus database using the following key words: "Kikushi disease", "Kikuchi-Fujimoto disease", "histiocytic necrotizing", "lymphadenitis","lymphadenopathy". Results:We report a case in a young patient with a fever associated with the emergence of adenomegaly and weight loss in two months, associated with hepatosplenomegaly. In laboratory tests showed anaemia with erythrocyte sedimentation rate (ESH) and lactate dehydrogenase (LDH) test elevated, widened mediastinum, with bilateral pleural effusion. Conclusion:Excisional biopsy of supraclavicular lymph node showed Kikuchi-Fujimoto disease on microscopic examination. After histopathological confirmation, were other causes of febrile adenomegaly apart, starting dose corticosteroid immunosuppressive therapy.

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SLE Developing in a Follow-Up Patient of Kikuchi’s Disease: A Rare Disorder

Cited by 17 publications

References 7 publications

Kikuchi – Fujimoto Disease. Case report and a brief review of the literature

Kikuchi – Fujimoto Disease. Case report and a brief review of the literature

Kikuchis lymphadenitis: Is biopsy necessary in managing these patients

Kikuchi-Fujimoto disease: case report and review

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