Sleep accelerates re-stabilization of human declarative memories

Moyano, Malen D.; Diekelmann, Susanne; Pedreira, Marı́a Eugenia; Forcato, Cecilia

doi:10.1016/j.nlm.2019.04.012

Cited by 17 publications

(13 citation statements)

References 25 publications

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“…Our finding of an immediate stabilization upon cueing during sleep suggests that sleep speeds up memory (re-)stabilization, such that the beneficial effects of incomplete reminders are already observed after shorter time intervals. In accordance, we have recently shown that sleep accelerates memory restabilization, shortening the time window during which a reactivated memory is susceptible to interference 50 . In the present study, the reactivated memories might have been re-stabilized already within thẽ 40-min sleep period, producing the short-term stabilization observed right after this sleep period.…”

Section: Discussionsupporting

confidence: 72%

Reactivation during sleep with incomplete reminder cues rather than complete ones stabilizes long-term memory in humans

et al. 2020

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Reactivation by reminder cues labilizes memories during wakefulness, requiring reconsolidation to persist. In contrast, during sleep, cued reactivation seems to directly stabilize memories. In reconsolidation, incomplete reminders are more effective in reactivating memories than complete reminders by inducing a mismatch, i.e. a discrepancy between expected and actual events. Whether mismatch is likewise detected during sleep is unclear. Here we test whether cued reactivation during sleep is more effective for mismatch-inducing incomplete than complete reminders. We first establish that only incomplete but not complete reminders labilize memories during wakefulness. When complete or incomplete reminders are presented during 40-min sleep, both reminders are equally effective in stabilizing memories. However, when extending the retention interval for another 7 hours (following 40-min sleep), only incomplete but not complete reminders stabilize memories, regardless of the extension containing wakefulness or sleep. We propose that, during sleep, only incomplete reminders initiate long-term memory stabilization via mismatch detection.

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Section: Discussionsupporting

confidence: 72%

Reactivation during sleep with incomplete reminder cues rather than complete ones stabilizes long-term memory in humans

et al. 2020

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“…So, even if the materials have been independently rated during the practical self-simulation task, it would be helpful to include more subjective evaluation indicators like imaginary difficulty and imaginary vividness. Third, sleep can deeply affect reconsolidation processing (Moyano et al, 2019), but this study did not collect data on the sleep state of the participants in the experiment and the time interval between learning/testing and sleeping. Future research can note and record these data to investigate the interesting interaction between reconsolidation and sleep, especially when emotional factors are involved.…”

Section: Discussionmentioning

confidence: 99%

Post-retrieval Distortions of Self-Referential Negative Memory: Valence Consistency Enhances Gist-Directed False, While Non-negative Interference Generates More Intrusive Updates

Pan

2021

Front. Psychol.

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According to the theory of reconsolidation, the contents of an original memory can be updated after reactivation with subsequent new learnings. However, there seems to be a lack of an appropriate behavioral paradigm to study the reconsolidation of explicit self-related memory, which is of great significance to further explore its cognitive neural mechanism in the future. In two separate experiments, we adapted a trial-by-trial interfering paradigm with a self-episodic simulation process and investigated (1) whether it is possible to reconsolidate negative memories under the new behavioral paradigm and (2) how the emotional valence of post-retrieval interference material affects the reconsolidation of negative memories. The results showed that the negative memories under trial-by-trial self-simulation can be degraded and updated via post-retrieval interference processes. Individuals whose original memories were reactivated by initial background cues and who were then presented with new interference situations were less able to recall original scenes and showed more memory intrusions on these scenes than those who had experienced new learning without reactivation or only reactivation without interference. Furthermore, the extent and manner of memory change/updating were greatly influenced by the characteristics of interference information. For memories with negative valences, new learning materials with the same valence produced superior interference effects in the form of lower correct recalls and more integrated false; whereas the neutral interference materials can cause more memory intrusion. Post-retrieval memory distortions of negative self-memory may underlie different functional mechanisms.

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“…The task consisted of memorizing five pairs of nonsense syllables, associated with a context formed by a background color on the computer screen, an image and music, presented through headphones (Moyano et al, 2019). The syllables were formed by three letters (Fig.…”

Section: The Taskmentioning

confidence: 99%

Non-Linear Susceptibility to Interferences in Declarative Memory Formation

Moyano

Carbonari²,

Bonilla

et al. 2021

Preprint

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After encoding, memories go through a labile state followed by a stabilization process known as consolidation. Once consolidated they can enter a new labile state after the presentation of a reminder of the original memory, followed by a period of re-stabilization (reconsolidation). During these periods of lability the memory traces can be modified. Currently, there are studies that show a rapid stabilization after 30 min, while others show that stabilization occurs after longer periods (e.g. 6 h). Here we investigate the effect of an interference treatment on declarative memory consolidation, comparing distinct time intervals after acquisition. On day 1, participants learned a list of non- syllable pairs (List 1). Immediately after, 30 min, 3 h or 8 h later, they received an interference list (List 2) that acted as an amnesic agent. On day 2 (48 h after training) participants had to recall List 1 first, followed by List 2. We found that the List 1 memory was susceptible to interference when the List 2 was administered immediately or 3 h after learning; however, shortly after acquisition (e.g. 30 min) the List 1 memory becomes transiently protected against interference. We propose the possibility that this rapid memory protection could be induced by a fast and transient neocortical integration (where the memory is transiently protected) becoming partially independent from the hippocampus followed by a hippocampal re-engagement where the memory becomes susceptible to interferences again. Our results open a discussion about the contribution of molecular and systemic aspects to memory consolidation.

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Sleep accelerates re-stabilization of human declarative memories

Cited by 17 publications

References 25 publications

Reactivation during sleep with incomplete reminder cues rather than complete ones stabilizes long-term memory in humans

Reactivation during sleep with incomplete reminder cues rather than complete ones stabilizes long-term memory in humans

Post-retrieval Distortions of Self-Referential Negative Memory: Valence Consistency Enhances Gist-Directed False, While Non-negative Interference Generates More Intrusive Updates

Non-Linear Susceptibility to Interferences in Declarative Memory Formation

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