Sleep and chronobiology in cluster headache

Barloese, Mads; Lund, Nunu; Petersen, Anja Sofie; Rasmussen, Mary-Jette; Jennum, Poul; Jensen, Rigmor Højland

doi:10.1177/0333102414564892

Cited by 106 publications

(192 citation statements)

References 27 publications

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“…They include peptides, such as substance P, neuropeptide Y, bradykinin, enkephalins, and atrial and brain natriuretic peptides [34], involved in the central regulation of pain, vasomotion, stress and sleep-wake rhythms as well as in the modulation of trigeminal nociceptive signals, whose alterations are thought to be implied in CH and to lead to the principal clinical features of this disease [3, 35, 36]. Interestingly, constitutive NEP knockout mice showed enhanced response to noxious thermal and chemical stimuli as well as thermal hyperalgesia and allodynia, and mechanical allodynia after chronic constriction injury of sciatic nerve [37].…”

Section: Discussionmentioning

confidence: 99%

A genome-wide analysis in cluster headache points to neprilysin and PACAP receptor gene variants

et al. 2016

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BackgroundCluster Headache (CH) is a severe primary headache, with a poorly understood pathophysiology. Complex genetic factors are likely to play a role in CH etiology; however, no confirmed gene associations have been identified. The aim of this study is to identify genetic variants influencing risk to CH and to explore the potential pathogenic mechanisms.MethodsWe have performed a genome-wide association study (GWAS) in a clinically well-defined cohort of 99 Italian patients with CH and in a control sample of 360 age-matched sigarette smoking healthy individuals, using the Infinium PsychArray (Illumina), which combines common highly-informative genome-wide tag SNPs and exonic SNPs. Genotype data were used to carry out a genome-wide single marker case-control association analysis using common SNPs, and a gene-based association analysis focussing on rare protein altering variants in 745 candidate genes with a putative role in CH.ResultsAlthough no single variant showed statistically significant association at the genome-wide threshold, we identified an interesting suggestive association (P = 9.1 × 10−6) with a common variant of the PACAP receptor gene (ADCYAP1R1). Furthermore, gene-based analysis provided significant evidence of association (P = 2.5 × 10−5) for a rare potentially damaging missense variant in the MME gene, encoding for the membrane metallo-endopeptidase neprilysin.ConclusionsOur study represents the first genome-wide association study of common SNPs and rare exonic variants influencing risk for CH. The most interesting results implicate ADCYAP1R1 and MME gene variants in CH susceptibility and point to a role for genes involved in pain processing. These findings provide new insights into the pathogenesis of CH that need further investigation and replication in larger CH samples.Electronic supplementary materialThe online version of this article (doi:10.1186/s10194-016-0705-y) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

A genome-wide analysis in cluster headache points to neprilysin and PACAP receptor gene variants

et al. 2016

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“…Previous studies found that sleep disturbances are a risk factor for headaches, as reviewed in previous studies. [12][13][14][15][16][17] Sleep disturbances in patients with eczema have recently been found to be associated with shorter stature 21 and poor health-related quality of life [22][23][24][25][26] in children and poorer overall health, 3 increased fractures and other injuries, 27 and even cardiovascular disease 28 in adults.…”

Section: Discussionmentioning

confidence: 99%

Association between childhood eczema and headaches: An analysis of 19 US population-based studies

Silverberg

2016

Journal of Allergy and Clinical Immunology

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“…Many of these features including yawning, fatigue, loss of appetite, and polyuria raise the potential for clear hypothalamic involvement in migraine given its role in sleep–wake states, appetite regulation, secretion of antidiuretic hormone (vasopressin), and nociceptive processing . While similar premonitory symptoms are not routinely reported in other primary headache disorders, the hypothalamus has gained significant attention due to the circadian and circannual periodicity of attacks including migraine and cluster headache . For example, several reports demonstrate a clear circadian pattern of migraine attack onset and circannual periodicity in cluster headaches that is inversely proportional to daylight length.…”

Section: The Emerging Role Of the Hypothalamus In Primary Headache DImentioning

confidence: 81%

“…While migraine therapy in particular is undergoing some seismic changes with the emergence of targeted calcitonin gene‐related peptide small molecule antagonists and monoclonal antibodies as well as neurally targeted serotonin 5‐HT 1F receptor agonists (ditans), there remains a significant unmet need to develop a greater understanding of the mechanisms of action of these and other potential therapeutic targets that may herald a way forward for future development. This is borne from a pre‐existing bias on treating the headache component of the disorder, considering that this may occur up to two to three days after the onset of the migraine attack, and given the clear circadian and circannual periodicity of migraine and cluster headache, there is potential for future therapies to target the non‐pain components of the attack with an aim of reducing attack susceptibility, progression, and ultimately preventing the headache.…”

Section: Introductionmentioning

confidence: 99%

Biology of Neuropeptides: Orexinergic Involvement in Primary Headache Disorders

Holland

2017

Headache

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Migraine is a very common, severe disabling condition that can last for days and strike multiple times per month. Attacks, often characterized by severe unilateral throbbing pain that is exacerbated by activity, are commonly preceded by several diverse symptoms including fatigue, irritability, and yawning. This premonitory (prodromal) phase represents the earliest identifiable feature of an attack that is a reliable predictor of ensuing headache. The diversity of these symptoms underlines the complex nature of migraine and focuses considerable attention on the hypothalamus due to its prominent role in homeostatic regulation allowing state dependent behavioral modifications. While multiple neurotransmitter and neuropeptide systems have been proposed to play a role in migraine, the current review will focus on the emerging role of the hypothalamic orexinergic system in primary headache disorders. Specifically the potential role of altered orexinergic signalling in premonitory symptomatology and the future potential of targeted orexinergic therapies that could with other approaches act during the premonitory phase to prevent the occurrence of the headache or reduce an individual's susceptibility to attacks by altering the brain's response to external and internal triggers.

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Sleep and chronobiology in cluster headache

Abstract: Diurnally, CH exhibits a relationship with night-time and annually with daylight hours. Patients' sleep quality is reduced compared with controls. Results suggest a complex relationship as sleep quality improves between clusters, but remains pathological.

Cited by 106 publications

References 27 publications

A genome-wide analysis in cluster headache points to neprilysin and PACAP receptor gene variants

A genome-wide analysis in cluster headache points to neprilysin and PACAP receptor gene variants

Association between childhood eczema and headaches: An analysis of 19 US population-based studies

Biology of Neuropeptides: Orexinergic Involvement in Primary Headache Disorders

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