Sleep and Metabolic Syndrome

Chasens, Eileen R.; Imes, Christopher C.; Kariuki, Jacob K; Luyster, Faith S.; Morris, Jonna L.; DiNardo, Monica; Godzik, Cassandra; Jeon, Bomin; Yang, Kyeongra

doi:10.1016/j.cnur.2020.10.012

Cited by 34 publications

(21 citation statements)

References 59 publications

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“…The present study found that the prevalence of CMD in ModSwDS was higher than that in ModS. This may be because insomnia can increase the excitability of the sympathetic nerve and the sympathetic‐adrenal medulla system hyperactivity, causing the level of catecholamines to rise, and increasing the burden on the circulatory system 3,26,27 ; insomnia can also cause excessive activation of the hypothalamus‐pituitary‐adrenergic axis, causing abnormal endocrine metabolism 26,28,29 . There was no significant difference in ESS between the two clinical subtypes.…”

Section: Discussionmentioning

confidence: 54%

“…This may be because insomnia can increase the excitability of the sympathetic nerve and the sympathetic-adrenal medulla system hyperactivity, causing the level of catecholamines to rise, and increasing the burden on the circulatory system 3,26,27 ; insomnia can also cause excessive activation of the hypothalamus-pituitary-adrenergic axis, causing abnormal endocrine metabolism. 26,28,29 There was no significant difference in ESS between the two clinical subtypes. Considering the difference in the prevalence of CMD between the two subtypes, clinical attention should be paid to the symptoms of insomnia in patients with OSA, and suitable treatment should be provided.…”

Section: Preliminary Identification Of Prevalent Cmd Of Clinical Subt...mentioning

confidence: 83%

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Differences in the prevalence of cardiovascular and metabolic diseases coinciding with clinical subtypes of obstructive sleep apnea

Gao

Guo

Dong

et al. 2022

Clinical Cardiology

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Background It is unclear about the cardiovascular and metabolic diseases (CMD) among Chinese patients with different clinical subtypes of obstructive sleep apnea (OSA). Hypothesis The prevalence of CMD varies among OSA patients of different clinical subtypes. Methods A total of 1483 Chinese patients with OSA were assessed to evaluate the existence of clinical subtypes of OSA using latent class analysis. We compared the differences in demographic characteristics and prevalence of CMD using ANOVA and χ 2 tests. Associations between clinical subtypes and disease prevalence were assessed using adjusted logistic regression. Results We identified prevalent CMD in Chinese patients with the four subtypes of OSA: excessively sleepy (ES), moderately sleepy with disturbed sleep (ModSwDS), moderately sleepy (ModS), and minimally symptomatic (MinS). The ES subtype had a higher body mass index, average Epworth Sleepiness Scale score, Apnea‐hypopnea index, and oxyhemoglobin saturation below 90% compared with the other subtypes ( p < .05). The MinS subtype had the lowest mean ESS score ( p < .05). We found a significant difference in the prevalence of CMD among the four subtypes, with the highest proportion of cases of CMD in the ES subtype. In adjusted models, significant associations with CMD were also found. ES, ModSwDS, ModS, and MinS subtypes are very high‐risk, high‐risk, medium‐risk, and low‐risk in prevalent CMD. Conclusions This study identified four clinical subtypes of OSA in Chinese patients. Each clinical subtype corresponds with a different level of prevalence of CMD; this finding is helpful for the more precise treatment of patients with different clinical manifestations.

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Section: Discussionmentioning

confidence: 54%

Section: Preliminary Identification Of Prevalent Cmd Of Clinical Subt...mentioning

confidence: 83%

Differences in the prevalence of cardiovascular and metabolic diseases coinciding with clinical subtypes of obstructive sleep apnea

Gao

Guo

Dong

et al. 2022

Clinical Cardiology

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“…There is increasing evidence of detrimental effects on metabolic function and dietary choices, emphasizing the importance of bolstering circadian system function and addressing sleep disruption [ 71 , 72 , 73 ]. Nowadays, it is common to be exposed to less light during the day and more light at night because of artificial lighting, which may impair circadian system organization and disrupt sleep, resulting in widespread adverse effects on metabolic health [ 74 , 75 , 76 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Relationship between Circadian Rhythms and Sleep, Metabolic and Cardiovascular Disorders: Current Clinical Evidence in Human Studies

et al. 2023

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Circadian rhythms are generated by the circadian clock, a self-sustained internal timing system that exhibits 24-h rhythms in the body. Many metabolic, cellular, behavioral and physiological processes are regulated by the circadian clock in coordination with environmental cues. The present study is a comprehensive review of the currently existing evidence concerning the relationship between circadian rhythms and sleep, metabolic, and cardiovascular disorders. We thoroughly searched the online databases PubMed, Scopus, and Web of Science to find the existing clinical studies from the last twenty-three years (2000–2023). Circadian misalignment was found to be associated with an increase in the risk of metabolic disorders, cardiovascular diseases, and obesity, as well as inadequate sleep quality. In this review article, all the included studies had a strength protocol design and all of them were conducted on humans. However, the most common limitations of them were the small sample size and the short time of the intervention. In conclusion, managing the factors that disrupt the optimal function of central and peripheral clocks can help to reduce the risk of metabolic and cardiovascular diseases, improving also sleep quality. Future studies should further explore the underlying mechanisms of the interconnections between circadian clocks and sleep, metabolic, and cardiovascular disorders. This may provide new opportunities for advance chronotherapy approach.

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“…Limitation of this study include the cross-sectional design that precludes the ability to infer causality and the use of an existing data set that did not include data of interest such as polysomnograms to objectively determine the presence and severity of OSA. Therefore, the effect of other sleep disorders such as short sleep duration, insomnia, and circadian misalignment that have been implicated as associated with MetS 32 need to be further evaluated. Notwithstanding these limitations, there are many strengths to the study that include the large, representative sample and objective measures of the various components of MetS.…”

Section: Limitationsmentioning

confidence: 99%

Obstructive Sleep Apnea Risk Is Associated With Severity of Metabolic Syndrome

et al. 2021

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Background: Metabolic syndrome (MetS) and obstructive sleep apnea (OSA) are associated with increased risk of cardiometabolic disease. The co-occurrence of OSA with MetS is common, but there are limited data on how OSA risk exacerbates the metabolic impairments present in MetS. The purpose of this analysis was to examine in a representative sample of participants in the National Health and Nutrition Examination Survey 2015-2018 cohorts (1) the association of modifiable cardiometabolic risk factors with OSA risk and MetS severity and (2) the influence of OSA risk and lifestyle behaviors on MetS severity. Methods: Metabolic syndrome severity was assessed using MetS Z score, whereas the risk of OSA was measured via multivariable apnea prediction index. Data analyses were conducted using the sample weights provided by the National Health and Nutrition Examination Survey. Results: The sample (N = 11 288) included adults (>20 years old) who were overweight (mean body mass index, 29.6 ± 0.2 kg/m 2 ), representative by race (36.9% non-White) and gender (51.9% female). Overall, 19.3% of the sample had elevated MetS severity (MetS Z score ≥ 1), and 38.4% were at a high risk of OSA (multivariable apnea prediction score of ≥0.50). High OSA risk was associated with having elevated MetS severity (odds ratio [OR], 4.94; 95% confidence interval [CI], 3. 68-6.65). Obstructive sleep apnea risk predicted increased MetS severity (adjusted: B = 0.06, SE = 0.02, P = .013). Physical activity provided the highest protection from increased MetS severity (OR, 0.52; 95% CI, 0.39-0.70) and OSA risk (OR, 0.59; 95% CI, 0.53-0.66). Conclusion: Our findings suggest that increased OSA risk exacerbates MetS severity and that greater physical activity may mitigate the risk.

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Sleep and Metabolic Syndrome

Cited by 34 publications

References 59 publications

Differences in the prevalence of cardiovascular and metabolic diseases coinciding with clinical subtypes of obstructive sleep apnea

Differences in the prevalence of cardiovascular and metabolic diseases coinciding with clinical subtypes of obstructive sleep apnea

Evaluating the Relationship between Circadian Rhythms and Sleep, Metabolic and Cardiovascular Disorders: Current Clinical Evidence in Human Studies

Obstructive Sleep Apnea Risk Is Associated With Severity of Metabolic Syndrome

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