Sleep and Stroke

Bassetti, Claudio L.

doi:10.1016/b978-1-4160-6645-3.00088-8

Cited by 22 publications

(9 citation statements)

References 223 publications

(250 reference statements)

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“…A substantive body of evidence has documented a close relationship between stroke and sleep disordered breathing 1 . However other changes in sleep after stroke are less well researched 2 .…”

Section: Introductionmentioning

confidence: 99%

Post-stroke insomnia in community-dwelling patients with chronic motor stroke: Physiological evidence and implications for stroke care

Sterr

Kühn

Nissen

et al. 2018

Sci Rep

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Questionnaire studies suggest that stroke patients experience sustained problems with sleep and daytime sleepiness, but physiological sleep studies focussing specifically on the chronic phase of stroke are lacking. Here we report for the first time physiological data of sleep and daytime sleepiness obtained through the two gold-standard methods, nocturnal polysomnography and the Multiple Sleep Latency Test. Data from community-dwelling patients with chronic right-hemispheric stroke (>12 months) were compared to sex- and age-matched controls. Behavioural and physiological measures suggested that stroke patients had poorer sleep with longer sleep latencies and lower sleep efficiency. Patients further spent more time awake during the night, and showed greater high-frequency power during nonREM sleep than controls. At the same time the Multiple Sleep Latency Test revealed greater wake efficiency in patients than controls. Importantly these findings were not due to group differences in sleep disordered breathing or periodic limb movements. Post-stroke insomnia is presently not adequately addressed within the care pathway for stroke. A holistic approach to rehabilitation and care provision, that includes targeted sleep interventions, is likely to enhance long-term outcome and quality of live in those living with chronic deficits after stroke.

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Section: Introductionmentioning

confidence: 99%

Post-stroke insomnia in community-dwelling patients with chronic motor stroke: Physiological evidence and implications for stroke care

Sterr

Kühn

Nissen

et al. 2018

Sci Rep

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“…Treatment of poststroke EDS which is not caused by the night sleep impairment is often doomed to failure. In individual patients, some improvement has been reported in thalamic and mesencephalic strokes treated with amphetamines, modafinil, methylphenidate, and dopaminergic agents [Bassetti, 2011].…”

Section: Strokementioning

confidence: 99%

Diagnosis and management of central hypersomnias

Šonka

Susta

2012

Ther Adv Neurol Disord

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Central hypersomnias are diseases manifested in excessive daytime sleepiness (EDS) not caused by disturbed nocturnal sleep or misaligned circadian rhythms. Central hypersomnias includes narcolepsy with and without cataplexy, recurrent hypersomnia, idiopathic hypersomnia, with and without long sleep time, behaviorally induced insufficient sleep syndrome, hypersomnia and narcolepsy due to medical conditions, and finally hypersomnia induced by substance intake. The Epworth Sleepiness Scale is a subjective tool mostly used for EDS assessment, while the Multiple Sleep Latency Test serves as an objective diagnostic method for narcolepsy and idiopathic hypersomnias. As for symptomatic therapy of EDS, the central nervous system stimulants modafinil and methylphenidate seem to work well in most cases and in narcolepsy and Parkinson's disease; sodium oxybate also has notable therapeutic value.

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“…Different thalamic nuclei play an important role in sleep regulation , and an impairment of the ascending brainstem arousal system to the median thalamus has been postulated as the cause of the hypersomnia in BTL . In addition, the paraventricular nucleus and the intergenicular leaflet are thalamic regions directly connected with the suprachiasmatic nucleus of the hypothalamus and involved in the regulation of circadian rhythms .…”

Section: Discussionmentioning

confidence: 99%

“…Hypersomnia, together with apathy and cognitive/behavioural dysfunction, is a prominent symptom in bilateral thalamic lesions (BTL), usually resulting from occlusion of the artery of Pecheron, a solitary trunk arising from the posterior cerebral artery and supplying the paramedian thalami . In the acute phase, hypersomnia may fluctuate and alternate with insomnia or sleep/wake cycle disruptions; in the long term, both recovery and persistence of hypersomnia have been described .…”

Section: Introductionmentioning

confidence: 99%