Sleep Apnea After 1 Year Domiciliary Nasal-Continuous Positive Airway Pressure and Attempted Weight Reduction

Noseda, André; Kempenaers, Chantal; Kerkhofs, Myriam; Houben, Jean-Jacques; Linkowski, Paul

doi:10.1378/chest.109.1.138

Cited by 53 publications

(29 citation statements)

References 20 publications

(7 reference statements)

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“…Others have reported a weight loss of 1.1-3.1 kg among their patients with a similar 3-month programme [6,24]. Poor results have been previously reported for conservative weight loss strategies, while the only substantial improvement in disease severity was achieved by gastro-jejunal surgery [25]. It has been postulated that in SAHS sufferers a lack of motivation, energy and vitality can make it difficult to achieve clinically significant loss in body weight.…”

Section: Discussionmentioning

confidence: 96%

Health utilities in evaluating intervention in the sleep apnoea/hypopnoea syndrome

2002

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Health utilities in evaluating intervention in the sleep apnoea/hypopnoea syndrome. I. Chakravorty, R.M. Cayton, A. Szczepura. #ERS Journals Ltd 2002. ABSTRACT: Formulating a rational health policy necessitates the ability to compare between different healthcare interventions and disease scenarios. Continuous positive airway pressure (CPAP) therapy with a conservative lifestyle strategy in sleep apnoea/ hypopnoea syndrome (SAHS) was evaluated using health utility and quality-adjusted life years (QALYs) as outcome measures.A total 71 SAHS (apnoea/hypopnoea index o15 h -1 ) patients completed a randomised, parallel group study over 3 months using utilities derived by the standard gamble approach (Usg) and European quality of life questionnaire (Euroqol) (Ueq).The severely impaired health status at baseline improved by 23% (Usg 0.32 to 0.55) adding 8 QALYs in the CPAP group, compared to a 4% improvement with 4.7 QALYs added in the lifestyle group (Usg 0.31 to 0.35). The Ueq showed a marginal change with CPAP (0.73 to 0.77) but did not demonstrate any improvement with lifestyle intervention.The health status impairment in sleep apnoea/hypopnoea syndrome patients is markedly improved by continuous positive airway pressure compared to a modest improvement with conservative lifestyle strategies using the standard gamble utility, which may be incorporated in effectiveness and economic analyses. The European quality of life questionnaire did not reflect a similar degree of impact and is probably not useful in this population.

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Section: Discussionmentioning

confidence: 96%

Health utilities in evaluating intervention in the sleep apnoea/hypopnoea syndrome

2002

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“…Weight loss improves the symptoms of obstructive sleep apnea 75 and reduces breathing disturbances during sleep.…”

Section: Therapeutic Implications Of Obesitymentioning

confidence: 99%

“…75 In another study, a 10% increase in weight predicted a 6-fold (95% CI 2.2-17.0) increase in the odds of developing moderate to severe obstructive sleep apnea. 76 Unfortunately, most patients are unable or unwilling to maintain a healthy body weight.…”

mentioning

confidence: 94%

The effect of obesity on chronic respiratory diseases: pathophysiology and therapeutic strategies

Poulain

Doucet²,

Major³

et al. 2006

Canadian Medical Association Journal

327

204

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Section: Introductionmentioning

confidence: 99%

“…Weight loss has been shown having a positive relationship with improvement in sleep parameters in literatures [6][7][8] . Furthermore, the need for CPAP was diminished by remarkable weight loss 6) . Weight loss provides not only improvement of OSAHS but also additional health benefits such as improvement of blood pressure, lipid levels and glucose metabolism, and therefore should be routinely recommended to most obese OSAHS subjects 9,10) .…”

Section: Introductionmentioning

confidence: 99%

Weight Loss Approach during Routine Follow-up is Effective for Obstructive Sleep Apnea Hypopnea Syndrome Subjects Receiving Nasal Continuous Positive Airway Pressure Treatment

Fujii

Miyamoto

et al. 2010

Ind Health

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The present study investigated the effectiveness of a weight loss program during routine medical follow-up with regularity on promoting weight reduction in obese obstructive sleep apnea hypopnea syndrome (OSAHS) subjects receiving continuous positive airway pressure treatment (CPAP). A total of 10 male obese OSAHS subjects treated with CPAP were enrolled in the present study that was an intervention study without a control and had a pre-post test study design. The age was 50.7 (7.8) (mean (SD)) years, and body mass index was 30.7 (2.5) kg/m 2 . A 4-month weight loss program was developed, using a combined approach of diet and physical activity based on individual counseling with behavioral approach. At 4 months, weight was significantly decreased compared with the baseline value (88.4 (8.9) kg to 86.9 (8.8) kg, p=0.005), and the mean weight loss was a 1.7% decrease from the baseline. There was significantly higher percent weight loss in the group with a CPAP duration <30 months, than in the group ≥30 months (2.7 (1.6) % vs. 0.6 (0.5) %, p=0.032). The present study shows that a weight loss program may be useful in reducing weight for male obese OSAHS subjects treated with CPAP.

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Sleep Apnea After 1 Year Domiciliary Nasal-Continuous Positive Airway Pressure and Attempted Weight Reduction

Cited by 53 publications

References 20 publications

Health utilities in evaluating intervention in the sleep apnoea/hypopnoea syndrome

Health utilities in evaluating intervention in the sleep apnoea/hypopnoea syndrome

The effect of obesity on chronic respiratory diseases: pathophysiology and therapeutic strategies

Weight Loss Approach during Routine Follow-up is Effective for Obstructive Sleep Apnea Hypopnea Syndrome Subjects Receiving Nasal Continuous Positive Airway Pressure Treatment

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