Sleep apnea syndrome in chronic renal disease

Kimmel, Paul L.; Miller, Gary; Mendelson, Wallace B.

doi:10.1016/0002-9343(89)90301-x

Cited by 249 publications

(194 citation statements)

References 25 publications

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“…Studies in the past have consistently shown a high prevalence of SDB (Ͼ50%) in patients on hemodialysis (HD) because of compromised upper airway stability (extracellular fluid volume overload) (1,2), ventilatory control instability (altered central and peripheral chemosensitivity), and reduced upper airway muscle tone (uremia) (3)(4)(5)(6)(7). Risk factors of SDB in the general population such as older age, male gender, obesity, smoking, increased neck circumference and diabetes are also prevalent in the CKD population (8).…”

Section: Introductionmentioning

confidence: 99%

Sleep-Disordered Breathing and Excessive Daytime Sleepiness in Chronic Kidney Disease and Hemodialysis

Roumelioti¹,

Buysse²,

Sanders³

et al. 2011

Clinical Journal of the American Society of Nephrology

108

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SummaryBackground and objectives Sleep-disordered breathing (SDB) and excessive daytime sleepiness (EDS) are highly prevalent among hemodialysis (HD) patients. It is unclear to what extent SDB is associated with advanced chronic kidney disease (CKD; stages 4 to 5). This paper describes and compares the prevalence, severity, and patterns of SDB and EDS among patients with advanced CKD, HD-dependent patients, and community individuals without known renal disease.Design, setting, participants, & measurements Eighty-nine CKD and 75 HD patients were compared with 224 participants from the Sleep-Strategies Concentrating on Risk Evaluation Sleep-SCORE study of sleep and cardiovascular risk. Participants had in-home unattended polysomnography for quantifying SDB. EDS was defined by a score Ն10 on the Epworth Sleepiness Scale.Results The sample had a median age 58.1 years, was predominantly male (57.4%) and white (62.5%), and had a median body mass index of 28.1 kg/m 2 . Controls and Sleep-SCORE Study CKD patients had significantly higher median total sleep time and sleep efficiency compared with HD patients. The adjusted odds of severe SDB were higher for CKD and HD groups compared with the controls. Nocturnal hypoxemia was significantly elevated in the HD group compared with the CKD group. There were similar proportions of participants with EDS between the controls (33%), the CKD patients (29.3%), and the HD patients (40.6%). ConclusionsSevere SDB (predominantly obstructive) and EDS are common among advanced CKD and HD patients. EDS correlated modestly with severe SDB and its obstructive and mixed patterns in the HD group.

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Section: Introductionmentioning

confidence: 99%

Sleep-Disordered Breathing and Excessive Daytime Sleepiness in Chronic Kidney Disease and Hemodialysis

Roumelioti¹,

Buysse²,

Sanders³

et al. 2011

Clinical Journal of the American Society of Nephrology

108

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show abstract

“…More than 50% of patients with ESRD have sleep apnea (7,19). Prevalence appears to be similar in advanced CKD patients who are not on dialysis and those treated with peritoneal or hemodialysis (7,20). Sleep Disordered Breathing (SDB) is observed with similar frequency in dialysis dependent and dialysis independent CKD patients.…”

Section: Sleep Apnea Syndrome (Sas)mentioning

confidence: 99%

Sleep Disorders Associated with Chronic Kidney Disease

Benz¹,

Pressman²,

Masood³

2012

Chronic Kidney Disease

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“…Studies have reported a high prevalence of SAS in patients with chronic kidney disease. Compared with the general population where the prevalence of SAS is estimated to be 2-4%, prevalence in the ESRD population appears to be 30% or more (Kuhlmann et al 2000;Young et al 1993;Kimmel et al 1989). This is partly explained by the fact that the most common comorbid conditions of ESRD, such as atherosclerosis and diabetes, are also independently associated with ESRD.…”

Section: Sleep Apnea Syndromementioning

confidence: 99%