Sleep apnoea in acromegaly.

Perks, W H; Horrocks, P. M.; Cooper, R.; Bradbury, Sarah; Allen, Angier; Baldock, N.M.; Prowse, K; Hoff, William van’t

doi:10.1136/bmj.280.6218.894

Cited by 111 publications

(39 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Many studies showed higher frequency of SAS in active acromegalic patients with a positive correlation with GH/IGF1 levels (3,12,13). Conversely, in the study of Grunstein et al (1) only the presence of central apnoea (CA), but not the degree of sleep apnoea, was associated with the disease activity.…”

Section: Introductionmentioning

confidence: 80%

Sleep apnoea syndrome is highly prevalent in acromegaly and only partially reversible after biochemical control of the disease

Davì

Carbonare

Giustina

et al. 2008

European Journal of Endocrinology

130

View full text Add to dashboard Cite

Background: Whether sleep apnoea syndrome (SAS) subsides after biochemical and clinical remission of acromegaly is controversial. Objective: To assess the presence of SAS in a cohort of acromegalic patients, which included a subgroup with active disease and a subgroup in remission, and to evaluate clinical and biochemical independent predictors of SAS. Design: Cross-sectional and longitudinal study. Setting: Italian university department of internal medicine. Patients: About 36 acromegalic patients: 18 active and 18 controlled. Measurements: Polysomnography was performed in all patients and repeated in six with active acromegaly and SAS after achieving disease control. Echocardiographic parameters were also measured. Results: The prevalence of SAS was 47% in the overall acromegalic population: 56% in the active group and 39% in the controlled one. In a multivariate analysis IGF1, male gender, age, body mass index, and disease duration were associated with SAS. Impaired glucose tolerance or diabetes was more prevalent in patients with SAS, particularly in the severe cases. Among the six patients of the longitudinal study, five showed improvement of SAS, but none recovered. No correlation was found between echocardiographic parameters and severity of SAS. Conclusion: SAS can persist after recovery of acromegaly in several patients. Given the negative prognostic significance of this respiratory disorder, polysomnography should be included as routine procedure in the work-up of the acromegaly, even if in remission, being mandatory in those patients considered at high risk (elderly males, overweight, diabetic). Appropriate intensive treatment should be implemented to minimize the clinical impact of SAS in acromegaly.

show abstract

Section: Introductionmentioning

confidence: 80%

Sleep apnoea syndrome is highly prevalent in acromegaly and only partially reversible after biochemical control of the disease

Davì

Carbonare

Giustina

et al. 2008

European Journal of Endocrinology

130

View full text Add to dashboard Cite

show abstract

“…AHI) with cardiorespiratory monitoring and various parameters in Japanese acromegalic patients, which to our knowledge is the first such report. Previous studies in European acromegalic patients showed that SDB correlates with high levels of GH and IGF-1 [3,13,15], aging [10,12,14,15], male gender, BMI [14], WC [14], neck circumference [15] and tongue size [30,31]. Although we reported previously that AHI correlated with BMI and WC in diabetic patients [20,21], the present study found no correlation between AHI and BMI and WC in acromegalic patients (Table 2), probably because acromegaly is often a disease with little fat but organ hypertrophy, different from diabetes.…”

Section: Correlation Analysis Between Ahi and Measured Parametersmentioning

confidence: 99%

Characteristics of sleep-disordered breathing in Japanese patients with acromegaly

et al. 2012

View full text Add to dashboard Cite

“…Infiltration of upper airway muscles and soft tissues can impair muscle function and reduce the upper airway lumen, as in myxoedema [47], acromegaly [48,49], involvement by neoplastic processes [50], and mucopolysaccharidoses [51], all of which have been associated with a predisposition to OSA. Treatment of the underlying process can reverse upper airway obstruction [47,50].…”

Section: Reduced Upper Airway Calibrementioning

confidence: 99%

Pathophysiology of obstructive sleep apnoea

Deegan¹,

McNicholas²

1995

Eur Respir J

264

183

View full text Add to dashboard Cite

Arousal plays an important role in the termination of each apnoea, but may also contribute to the development of further apnoea, because of a reduction in respiratory drive related to the hypocapnia which results from postapnoeic hyperventilation. A cyclical pattern of repetitive obstructive apnoeas may result.A better understanding of the integrated pathophysiology of OSA should help in the development of new therapeutic techniques.

show abstract

Sleep apnoea in acromegaly.

Abstract: consultant physician W VAN'T HOFF, Ma, FRcp, consultant physician important in acromegaly, and it may be central, obstructive, or mixed. Polygraphic nocturnal monitoring is indicated to assess these patients properly.

Cited by 111 publications

References 7 publications

Sleep apnoea syndrome is highly prevalent in acromegaly and only partially reversible after biochemical control of the disease

Sleep apnoea syndrome is highly prevalent in acromegaly and only partially reversible after biochemical control of the disease

Characteristics of sleep-disordered breathing in Japanese patients with acromegaly

Pathophysiology of obstructive sleep apnoea

Contact Info

Product

Resources

About