Sleep architecture and the risk of incident dementia in the community

Pase, Matthew P.; Himali, Jayandra J.; Grima, Natalie; Beiser, Alexa; Satizabal, Claudia L.; Aparicio, Hugo J.; Thomas, Robert J.; Gottlieb, Daniel J.; Auerbach, S. H.; Seshadri, Sudha

doi:10.1212/wnl.0000000000004373

Cited by 174 publications

(122 citation statements)

References 30 publications

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“…Even if the majority of the most recent papers focused on NREM sleep and cognition, an impairment of REM sleep in AD is well known (Moe, Vitiello, Larsen, & Prinz, ) and has been related to the dysfunction of cholinergic system, especially in the basal forebrain that was reported in AD pathology. In this context, it is noticeable that in a PSG study on a population of HE, with a mean follow‐up of 12 years, lower REM sleep percentage was associated with a higher risk of incident dementia (Pase et al., ). However, the specificity of REM sleep alteration needs to be further tested as in the latter paper, as well as in our population, REM changes are present also in subjects not evolving to dementia at follow‐up.…”

Section: Discussionmentioning

confidence: 99%

A longitudinal study of polysomnographic variables in patients with mild cognitive impairment converting to Alzheimer's disease

Carnicelli

Maestri

Coscio

et al. 2019

Journal of Sleep Research

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The main condition at increased risk of dementia is considered to be mild cognitive impairment. Mild cognitive impairment has been defined as a transitional state between normal aging and dementia, of which it may represent a prodrome. The aim of our study was to evaluate whether sleep variables (both conventional and microstructural ones) in subjects with mild cognitive impairment correlate with conversion to dementia. Nineteen subjects with amnestic mild cognitive impairment (mean age 68.5 ± 7.0 years) and 11 cognitively intact healthy elderly individuals (mean age 69.2 ± 12.6 years) underwent ambulatory polysomnography for the evaluation of nocturnal sleep architecture and cyclic alternating pattern parameters. Amnestic mild cognitive impairment subjects were clinically and cognitively re‐evaluated after 2 years, during routine follow‐up, and further classified as amnestic mild cognitive impairment converters (that is, patients developing Alzheimer's disease, N = 11) and amnestic mild cognitive impairment non‐converters. Compared with healthy elderly individuals, amnestic mild cognitive impairment showed disrupted sleep with decreased rapid eye movement sleep, cyclic alternating pattern rate and cyclic alternating pattern slow‐wave‐related phases (A1 index). Standard sleep architecture analysis did not show significant differences between the two subgroups of amnestic mild cognitive impairment, whereas cyclic alternating pattern analysis showed that cyclic alternating pattern rate, A1 index and A3 index are significantly reduced in converters compared with non‐converters. Our data confirm that in amnestic mild cognitive impairment subjects there is a sleep impairment, particularly when considering more refined sleep parameters and that sleep variables at baseline are different among converters versus non‐converters at the 2‐year follow‐up. Specific sleep alterations might represent potential further biomarkers for the diagnosis and prognosis of early‐phase cognitive impairment.

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Section: Discussionmentioning

confidence: 99%

A longitudinal study of polysomnographic variables in patients with mild cognitive impairment converting to Alzheimer's disease

Carnicelli

Maestri

Coscio

et al. 2019

Journal of Sleep Research

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“…As, cholinergic neurons are important determinants of REM sleep, with cholinergic activity low during SWS and high during REM sleep [32]. Stroke causes a central imbalance of neurotransmitters, such as acetylcholine, serotonin, and melatonin, causing sleep structure abnormalities [33].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Sleep Pattern in Egyptian Elderly with Vascular Dementia

Alloush¹,

Sweed²,

Abdelnaser³

et al. 2019

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Study Objectives: Growing evidence suggests that sleep disturbances is common in vascular dementia (VaD). The goal of the current study is to assess the disturbance in sleep pattern in patients with VaD, and compare it to healthy normally cognitive elderly individuals. We next studied whether there are meaningful differences in the Subjective sleep assessment: Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI) and sleep measurements by polysomnography (PSG) in VaD patients. Study design: Case control study. Subject and methods: Overnight PSG recordings and self-reported sleep measures were obtained from 20 healthy elderly subjects and 20 VaD patients at the sleep laboratory. Results: This study showed abnormal subjective sleep quality in all patients and revealed that the most common sleep complaints among VaD patients were: excessive daytime sleepiness (EDS), sleep disordered breathing (SDB), insomnia, restless leg syndrome (RLS), periodic limb movements (PLMS) and REM behavioral disordered (RBD) respectively. Moreover, patients spent more time in stage I sleep, but less time in slow wave sleep (SWS) and REM sleep compared to control populations, with de-

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“…Представленість фази парадоксального сну і тривалість його першого епізоду в циклі неспання-сон: а -фаза парадоксального сну, б -тривалість першого епізоду парадоксального сну; I -контроль, II-V -7, 14, 21, 28-ма доба після операції з моделювання ХА відповідно; *P < 0,1; ***P < 0,02; ****P < 0,01; *****P < 0,001 порівняно з контролем; # P < 0,1; ## P < 0,05; ### P < 0,02; #### P < 0,01 порівняно з 7-ю добою I III V II IV I III V II 1 му добу після індукції нейродегенеративних порушень. Отримані результати свідчать про залучення до патологічного процесу центрів регуляції парадоксального сну, локалізованих у задніх відділах мозку, що узгоджується з даними літератури про значний вплив його параметрів на ризик розвитку деменції [24].…”

Section: результати та їх обговоренняunclassified

Characteristics of Wake-Sleep Cycle Organization Under Alzheimer’s Disease Modeling in Rats

Geyko¹,

Берченко²,

Levicheva³

et al. 2020

Fiziol Zh

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Sleep architecture and the risk of incident dementia in the community

Abstract: Despite contemporary interest in slow-wave sleep and dementia pathology, our findings implicate REM sleep mechanisms as predictors of clinical dementia.

Cited by 174 publications

References 30 publications

A longitudinal study of polysomnographic variables in patients with mild cognitive impairment converting to Alzheimer's disease

A longitudinal study of polysomnographic variables in patients with mild cognitive impairment converting to Alzheimer's disease

Assessment of Sleep Pattern in Egyptian Elderly with Vascular Dementia

Characteristics of Wake-Sleep Cycle Organization Under Alzheimer’s Disease Modeling in Rats

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