Sleep-Dependent Synaptic Down-Selection (I): Modeling the Benefits of Sleep on Memory Consolidation and Integration

Nere, Andrew; Hashmi, Atif; Cirelli, Chiara; Tononi, Giulio

doi:10.3389/fneur.2013.00143

Cited by 69 publications

(77 citation statements)

References 90 publications

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“…Both spindles [14] and SWRs [12, 13] are considered to trigger surges in intracellular Ca 2+ levels suitable for synaptic plasticity and have been linked to memory improvements following sleep [3]. These and other observations have led to speculation that reactivation of neuronal ensembles during spindle/SWR complexes, coordinated by slow waves, plays a pivotal role in systems consolidation of memory [1, 3, 19, 22, 35] and may spare ensembles from synaptic downscaling [7, 36]. Our study suggests that they may also play a central role in the regulation of neuronal activity and connectivity.…”

Section: Discussionmentioning

confidence: 99%

Regulation of Hippocampal Firing by Network Oscillations during Sleep

2016

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It has been hypothesized that waking leads to higher firing neurons, with increased energy expenditure, and sleep serves to return activity to baseline levels. Oscillatory activity patterns during different stages of sleep may play specific roles in this process, but consensus has been missing. To evaluate these phenomena in the hippocampus, we recorded from region CA1 neurons in rats across the 24-hr cycle and found that their firing increased upon waking, and decreased 11 % per hr across sleep. Waking and sleep also affected lower and higher firing neurons differently. Interestingly, the incidences of sleep spindles and sharp-wave ripples (SWRs), typically associated with cortical plasticity, were predictive of ensuing firing changes and more robustly than were other oscillatory events. Spindles and SWRs were initiated during non-REM sleep yet the changes were incorporated in the network over the following REM sleep epoch. These findings indicate an important role for spindles and SWRs and provide novel evidence of a symbiotic relationship between non-REM and REM stages of sleep in the homeostatic regulation of neuronal activity.

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Section: Discussionmentioning

confidence: 99%

Regulation of Hippocampal Firing by Network Oscillations during Sleep

2016

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“…The synaptic homeostasis model states that the synaptic strengths saturated during cognitive processing are 'sheared off' during sleep, especially SWS, leaving task-relevant synaptic connections intact and freeing up capacity for subsequent learning [144][145][146]. Reports in rodents and Drosophila support the possibility that net synaptic strength is increased during waking and decreased during SWS [147,148].…”

Section: Box 3 Theoretical Models Explaining Sleep-dependent Memory mentioning

confidence: 96%

The Sleeping Cerebellum

Canto

Onuki

Bruinsma

et al. 2017

Trends in Neurosciences

153

105

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We sleep almost one-third of our lives and sleep plays an important role in critical brain functions like memory formation and consolidation. The role of sleep in cerebellar processing, however, constitutes an enigma in the field of neuroscience; we know little about cerebellar sleep-physiology, cerebro-cerebellar interactions during sleep, or the contributions of sleep to cerebellum-dependent memory consolidation. Likewise, we do not understand why cerebellar malfunction can lead to changes in the sleep-wake cycle and sleep disorders. In this review, we evaluate how sleep and cerebellar processing may influence one another and highlight which scientific routes and technical approaches could be taken to uncover the mechanisms underlying these interactions.

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“…Because only the strongest memories are conserved, consolidation would result from a higher signal-to-noise ratio rather than an absolute increase in memory strength 21 . Another consequence of synaptic downscaling would be an increased difficulty in forming new mnesic traces.…”

Section: Introductionmentioning

confidence: 99%

Formation and suppression of acoustic memories during human sleep

et al. 2017

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Sleep and memory are deeply related, but the nature of the neuroplastic processes induced by sleep remains unclear. Here, we report that memory traces can be both formed or suppressed during sleep, depending on sleep phase. We played samples of acoustic noise to sleeping human listeners. Repeated exposure to a novel noise during Rapid Eye Movements (REM) or light non-REM (NREM) sleep leads to improvements in behavioral performance upon awakening. Strikingly, the same exposure during deep NREM sleep leads to impaired performance upon awakening. Electroencephalographic markers of learning extracted during sleep confirm a dissociation between sleep facilitating memory formation (light NREM and REM sleep) and sleep suppressing learning (deep NREM sleep). We can trace these neural changes back to transient sleep events, such as spindles for memory facilitation and slow waves for suppression. Thus, highly selective memory processes are active during human sleep, with intertwined episodes of facilitative and suppressive plasticity.

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Sleep-Dependent Synaptic Down-Selection (I): Modeling the Benefits of Sleep on Memory Consolidation and Integration

Cited by 69 publications

References 90 publications

Regulation of Hippocampal Firing by Network Oscillations during Sleep

Regulation of Hippocampal Firing by Network Oscillations during Sleep

The Sleeping Cerebellum

Formation and suppression of acoustic memories during human sleep

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