Sleep deprivation alters energy homeostasis through non-compensatory alterations in hypothalamic insulin receptors in Wistar rats

Moraes, Danilo Alves de; Venâncio, Daniel Paulino; Suchecki, Deborah

doi:10.1016/j.yhbeh.2014.08.015

Cited by 23 publications

(22 citation statements)

References 63 publications

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“…) or that increased food intake occurs only during the diurnal phase of the light–dark cycle (Galvão et al . ; Moraes et al ., ); nonetheless, studies that use liquid diet, which prevents spillage, also report increased food intake (Koban et al . ; Martins et al .…”

Section: Discussionmentioning

confidence: 99%

Restriction of rapid eye movement sleep during adolescence increases energy gain and metabolic efficiency in young adult rats

Ribeiro-Silva

Nejm

Silva

et al. 2016

Experimental Physiology

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New Findings r What is the central question of this study?Sleep curtailment in infancy and adolescence may lead to long-term risk for obesity, but the mechanisms involved have not yet been determined. This study examined the immediate and long-term metabolic effects produced by sleep restriction in young rats. r What is the main finding and its importance?Prolonged sleep restriction reduced weight gain (body fat stores) in young animals. After prolonged recovery, sleep-restricted rats tended to save more energy and to store more fat, possibly owing to increased gross food efficiency. This could be the first step to understand this association.Sleep curtailment is associated with obesity and metabolic changes in adults and children. The aim of the present study was to evaluate the immediate and long-term metabolic alterations produced by sleep restriction in pubertal male rats. Male Wistar rats (28 days old) were allocated to a control (CTL) group or a sleep-restricted (SR) group. This was accomplished by the single platform technique for 18 h per day for 21 days. These groups were subdivided into the following four time points for assessment: sleep restriction and 1, 2 and 4 months of recovery. Body weight and food intake were monitored throughout the experiment. At the end of each time period, blood was collected for metabolic profiling, and the carcasses were processed for measurement of body composition and energy balance. During the period of sleep restriction, SR animals consumed less food in the home cages. This group also displayed lower body weight, body fat, triglycerides and glucose levels than CTL rats. At the end of the first month of recovery, despite eating as much as CTL rats, SR animals showed greater energy and body weight gain, increased gross food efficiency and decreased energy expenditure. At the end of the second and fourth months of recovery, the groups were no longer different, except for energy gain and gross food efficiency, which remained higher in SR animals. In conclusion, sleep restriction affected weight gain of young animals, owing to reduction of fat stores. Two months were sufficient to recover this deficit and to reveal that SR rats tended to save more energy and to store more fat.

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Section: Discussionmentioning

confidence: 99%

Restriction of rapid eye movement sleep during adolescence increases energy gain and metabolic efficiency in young adult rats

Ribeiro-Silva

Nejm

Silva

et al. 2016

Experimental Physiology

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“…Toll-like signalling pathway comprises type I transmembrane receptors. After activation, TLRs homodimerise and activate the tumour necrosis-factor associated factor 6 (TRAF6) adapter protein [45]. TRAF6 triggers an enzymatic complex, and decoupling NFκB in NFκBp50 and NFκBp65 dimers through degradation of its inhibitory protein IκB [45].…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Grape and Apple Juices against Cadmium Intoxication in the Kidney of Rats

et al. 2020

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Background The objective of this study was to evaluate protective effect of grape and apple juices against toxicity induced by cadmium in the kidney of rats. Methods A total of 20 male-Wistar rats were distributed into four groups (n=5): Control group: animals received an intraperitoneal (i.p.) injection of 0.9% saline solution and after 15 days, 1 mL of water was administered for 15 days, via gavage; Cadmium group: animals received an intraperitoneal injection of cadmium chloride (1.2 mg/kg) and after 15 days, 1 mL of water was administered for 15 days via gavage; Cadmium+Grape Juice: animals received an i.p. injection of cadmium chloride (1.2 mg/kg), and after 15 days, 0.8 mL of grape juice was administered for 15 days, via gavage; Cadmium+Apple Juice: animals received i.p. injection of cadmium chloride (1.2 mg/kg) and after 15 days, 1.0 mL of apple juice was administered for 15 days, via gavage. Results Histopathological analysis revealed severe tubular lesion and necrosis in the group exposed to cadmium, while animals exposed to grape or apple juices showed a significant reduction of tissue injury. 8-OHdG immunoexpression, DNA damage, cytochrome C and catalase gene expressions and Toll like signaling pathway (TLR2, and pIKKα/β) decreased in animals treated with grape juice when compared to cadmium group. Conclusion Taken together, we conclude that grape and apple juices had a protective effect by means of antioxidant, antigenotoxic actions and for promoting tissue regeneration in the kidney of rats following cadmium intoxication.

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“…Generally, normal daily patterns of many behaviours and physiological systems are regulated by sleepwakefulness cycle, that any interruption in this cycle acts as a physiological stressor and metabolic challenge [5]. It impairs energy homoeostasis [6] as well as immune and hormonal functions. It also exacerbates generation of free radicals and inflammatory markers.…”

Section: Introductionmentioning

confidence: 99%

“…It also exacerbates generation of free radicals and inflammatory markers. In this regard, it can be considered as a potential risk for obesity, diabetes, cardiovascular and inflammatory diseases [6].…”

Section: Introductionmentioning

confidence: 99%

A Protocol for Conventional Sleep Deprivation Methods in Rats

Mahmoudi

Ahmadian²,

Farajdokht

et al. 2017

j of exper clin neur

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Sleep deprivation alters energy homeostasis through non-compensatory alterations in hypothalamic insulin receptors in Wistar rats

Cited by 23 publications

References 63 publications

Restriction of rapid eye movement sleep during adolescence increases energy gain and metabolic efficiency in young adult rats

Restriction of rapid eye movement sleep during adolescence increases energy gain and metabolic efficiency in young adult rats

Protective Effect of Grape and Apple Juices against Cadmium Intoxication in the Kidney of Rats

A Protocol for Conventional Sleep Deprivation Methods in Rats

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