Sleep Deprivation and Adaptive Hormonal Responses of Healthy Men

Mr, González-Santos; Ov, Gajá-Rodríguez; R, Alonso-Uriarte; Sojo-Aranda, I.; Cortés-Gallegos,

doi:10.3109/01485018908986773

Cited by 27 publications

(21 citation statements)

References 20 publications

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“…A recent study in young healthy men has demonstrated a distinct reduction in circulating testosterone levels after sleep curtailment to 5 h per night for 8 days . This finding is in line with previous studies showing a reduction in male pituitary–gonadal axis activity after more extreme forms of sleep restriction, that is, reduced circulating concentrations of luteinizing hormone (LH) and testosterone (T) as well as prolactin (PRL) after 24–48 h of total sleep deprivation. Such alterations, particularly in T levels, may impair sexual and reproductive functioning and adversely affect body composition, muscle strength, glucose metabolism and psychological well‐being .…”

Section: Introductionsupporting

confidence: 85%

Sleep timing may modulate the effect of sleep loss on testosterone

Schmid

Hallschmid

Jauch‐Chara

et al. 2012

Clinical Endocrinology

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Section: Introductionsupporting

confidence: 85%

Sleep timing may modulate the effect of sleep loss on testosterone

Schmid

Hallschmid

Jauch‐Chara

et al. 2012

Clinical Endocrinology

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“…TSD has repeatedly been shown to significantly decrease testosterone levels in male rats and humans (3,13,36). The decreased testosterone levels in our study were correlated to reductions of MSNA in men (Fig.…”

Section: Discussionsupporting

confidence: 68%

“…Given the reported associations between short sleep duration and hypertension in women (7), we hypothesized an augmented pressor response to TSD that would be associated with a potentiated MSNA response in women (i.e., an increase of MSNA compared with men). Because sleep deprivation has been shown to alter sex steroids (13), we also examined the potential interactions between TSD, sex steroids, and MSNA.…”

mentioning

confidence: 99%

Sympathetic neural responses to 24-hour sleep deprivation in humans: sex differences

Carter

Durocher

Larson

et al. 2012

American Journal of Physiology-Heart and Circulatory Physiology

116

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Sleep deprivation has been linked to hypertension, and recent evidence suggests that associations between short sleep duration and hypertension are stronger in women. In the present study we hypothesized that 24 h of total sleep deprivation (TSD) would elicit an augmented pressor and sympathetic neural response in women compared with men. Resting heart rate (HR), blood pressure (BP), and muscle sympathetic nerve activity (MSNA) were measured in 30 healthy subjects (age, 22 ± 1; 15 men and 15 women). Relations between spontaneous fluctuations of diastolic arterial pressure and MSNA were used to assess sympathetic baroreflex function. Subjects were studied twice, once after normal sleep and once after TSD (randomized, crossover design). TSD elicited similar increases in systolic, diastolic, and mean BP in men and women (time, P < 0.05; time × sex, P > 0.05). TSD reduced MSNA in men (25 ± 2 to 16 ± 3 bursts/100 heart beats; P = 0.02), but not women. TSD did not alter spontaneous sympathetic or cardiovagal baroreflex sensitivities in either sex. However, TSD shifted the spontaneous sympathetic baroreflex operating point downward and rightward in men only. TSD reduced testosterone in men, and these changes were correlated to changes in resting MSNA (r = 0.59; P = 0.04). Resting HR, respiratory rate, and estradiol were not altered by TSD in either sex. In conclusion, TSD-induced hypertension occurs in both sexes, but only men demonstrate altered resting MSNA. The sex differences in MSNA are associated with sex differences in sympathetic baroreflex function (i.e., operating point) and testosterone. These findings may help explain why associations between sleep deprivation and hypertension appear to be sex dependent.

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“…Research on the relationship between sleep and testosterone has predominantly focused on the effect of total sleep deprivation [43], [44], [68], or examined the differential effects of sleep stages on testosterone [69]–[73]. Given the relationship between total sleep time and morning testosterone [72], it is unsurprising that the only published data to date on the relationship between sleep restriction and testosterone found that levels decreased significantly after 8 nights of 5 hours time in bed [45].…”

Section: Discussionmentioning

confidence: 99%

Impact of Five Nights of Sleep Restriction on Glucose Metabolism, Leptin and Testosterone in Young Adult Men

et al. 2012

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BackgroundSleep restriction is associated with development of metabolic ill-health, and hormonal mechanisms may underlie these effects. The aim of this study was to determine the impact of short term sleep restriction on male health, particularly glucose metabolism, by examining adrenocorticotropic hormone (ACTH), cortisol, glucose, insulin, triglycerides, leptin, testosterone, and sex hormone binding globulin (SHBG).Methodology/Principal FindingsN = 14 healthy men (aged 27.4±3.8, BMI 23.5±2.9) underwent a laboratory-based sleep restriction protocol consisting of 2 baseline nights of 10 h time in bed (TIB) (B1, B2; 22:00–08:00), followed by 5 nights of 4 h TIB (SR1–SR5; 04:00–08:00) and a recovery night of 10 h TIB (R1; 22:00–08:00). Subjects were allowed to move freely inside the laboratory; no strenuous activity was permitted during the study. Food intake was controlled, with subjects consuming an average 2000 kcal/day. Blood was sampled through an indwelling catheter on B1 and SR5, at 09:00 (fasting) and then every 2 hours from 10:00–20:00. On SR5 relative to B1, glucose (F 1,168 = 25.3, p<0.001) and insulin (F 1,168 = 12.2, p<0.001) were increased, triglycerides (F 1,168 = 7.5, p = 0.007) fell and there was no significant change in fasting homeostatic model assessment (HOMA) determined insulin resistance (F 1,168 = 1.3, p = 0.18). Also, cortisol (F 1,168 = 10.2, p = 0.002) and leptin (F 1,168 = 10.7, p = 0.001) increased, sex hormone binding globulin (F 1,167 = 12.1, p<0.001) fell and there were no significant changes in ACTH (F 1,168 = 0.3, p = 0.59) or total testosterone (F 1,168 = 2.8, p = 0.089).Conclusions/SignificanceSleep restriction impaired glucose, but improved lipid metabolism. This was associated with an increase in afternoon cortisol, without significant changes in ACTH, suggesting enhanced adrenal reactivity. Increased cortisol and reduced sex hormone binding globulin (SHBG) are both consistent with development of insulin resistance, although hepatic insulin resistance calculated from fasting HOMA did not change significantly. Short term sleep curtailment leads to changes in glucose metabolism and adrenal reactivity, which when experienced repeatedly may increase the risk for type 2 diabetes.

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Sleep Deprivation and Adaptive Hormonal Responses of Healthy Men

Cited by 27 publications

References 20 publications

Sleep timing may modulate the effect of sleep loss on testosterone

Sleep timing may modulate the effect of sleep loss on testosterone

Sympathetic neural responses to 24-hour sleep deprivation in humans: sex differences

Impact of Five Nights of Sleep Restriction on Glucose Metabolism, Leptin and Testosterone in Young Adult Men

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