Sleep deprivation inhibits adult neurogenesis in the hippocampus by elevating glucocorticoids

Abstract

Prolonged sleep deprivation is stressful and has been associated with adverse consequences for health and cognitive performance. Here, we show that sleep deprivation inhibits adult neurogenesis at a time when circulating levels of corticosterone are elevated. Moreover, clamping levels of this hormone prevents the sleep deprivation-induced reduction of cell proliferation. The recovery of normal levels of adult neurogenesis after chronic sleep deprivation occurs over a 2-wk period and involves a temporary increase in new neuron formation. This compensatory increase is dissociated from glucocorticoid levels as well as from the restoration of normal sleep patterns. Collectively, these findings suggest that, although sleep deprivation inhibits adult neurogenesis by acting as a stressor, its compensatory aftereffects involve glucocorticoid-independent factors. dentate gyrus ͉ stress ͉ corticosterone ͉ cell proliferation ͉ adrenal steroids

Central Mechanisms of HPA Axis Regulation by Voluntary Exercise

“…This study also examined the protective effects of running against stress-induced alterations in rapid-eye-movement (REM) sleep patterns. Sedentary mice exposed to social defeat in the resident intruder paradigm typically exhibit reductions in REM sleep (Lancel et al 2003), and sleep deprivation has been linked to increases in circulating corticosterone (Mirescu et al 2006). Socialdefeat-induced reductions in REM sleep are mitigated by voluntary running, but this is not mediated by reduced corticosterone, since runners actually show increased reactivity to the stressor (Lancel et al 2003).…”

Adult Neurogenesis and Mental Illness

“…Similarly, in animal studies, sleep deprivation can increase anxiety-like behavior in mice (Silva et al, 2004), and rodent models of anxiety, depression, and schizophrenia produce fragmented sleep (Grnli et al, 2004;Jakubcakova et al, 2012;Oliver et al, 2012;Phillips et al, 2012;Popa et al, 2006). The production of new neurons in the dentate gyrus is also inhibited by chronic sleep restriction or fragmentation (Mirescu et al, 2006).…”

Hubungan Penggunaan Media Elektronik dan Gangguan Tidur

“…Kurang tidur dalam jangka waktu lama dapat menyebabkan peningkatan hormon glukokortikoid yang dapat menghambat proses neurogenesis pada hipokampus yang berdampak pada proses belajar dan ingatan. 6 Abe dkk 7 melaporkan bahwa remaja yang tidur setelah tengah malam memiliki hubungan dengan menurunnya kontrol impuls. Hal tersebut karena kurang tidur, baik secara kualitatif dan kuantitatif, dapat meningkatkan sekresi kortisol dan adrenalin sehingga memengaruhi tingkat kegelisahan dan kontrol impuls.…”