Sleep-disordered breathing in children with congenital muscular dystrophies

Pinard, Jean-Marc; Azabou, Éric; Essid, N.; Quijano‐Roy, Susana; Haddad, Samir H.; Chéliout-Héraut, F.

doi:10.1016/j.ejpn.2012.02.009

Cited by 24 publications

(13 citation statements)

References 29 publications

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“…f ) Most studies are class III or IV and do not clearly describe risk factors for OSAS in children with neuromuscular disorders [35][36][37]. Absence of diurnal or nocturnal symptoms does not exclude OSAS [38].…”

Section: Literature Reviewmentioning

confidence: 99%

Obstructive sleep disordered breathing in 2- to 18-year-old children: diagnosis and management

et al. 2015

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This document summarises the conclusions of a European Respiratory Society Task Force on the diagnosis and management of obstructive sleep disordered breathing (SDB) in childhood and refers to children aged 2-18 years. Prospective cohort studies describing the natural history of SDB or randomised, double-blind, placebo-controlled trials regarding its management are scarce. Selected evidence (362 articles) can be consolidated into seven management steps. SDB is suspected when symptoms or abnormalities related to upper airway obstruction are present (step 1). Central nervous or cardiovascular system morbidity, growth failure or enuresis and predictors of SDB persistence in the long-term are recognised (steps 2 and 3), and SDB severity is determined objectively preferably using polysomnography (step 4). Children with an apnoea-hypopnoea index (AHI) >5 episodes·h, those with an AHI of 1-5 episodes·h −1 and the presence of morbidity or factors predicting SDB persistence, and children with complex conditions (e.g. Down syndrome and Prader-Willi syndrome) all appear to benefit from treatment (step 5). Treatment interventions are usually implemented in a stepwise fashion addressing all abnormalities that predispose to SDB (step 6) with re-evaluation after each intervention to detect residual disease and to determine the need for additional treatment (step 7). @ERSpublications Management of obstructive sleep disordered breathing in childhood should follow a stepwise approach

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Section: Literature Reviewmentioning

confidence: 99%

Obstructive sleep disordered breathing in 2- to 18-year-old children: diagnosis and management

et al. 2015

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“…Children with NMD may present with OSA, central sleep apneas, and/or nocturnal hypoventilation. 9,49 Nocturnal hypoxemia occurs preferentially during rapid eye-movement sleep because of the suppression of the ribcage and accessory inspiratory muscles, and because of more irregular, rapid, and shallow breathing. 5,6 Clinical Utility of Respiratory Muscle Testing in Children Precise respiratory muscle phenotyping may improve the understanding of the natural history of NMD and the evaluation of disease severity.…”

Section: Sleep Studymentioning

confidence: 99%

The Value of Respiratory Muscle Testing in Children With Neuromuscular Disease

Fauroux

Quijano‐Roy

Desguerre

et al. 2015

Chest

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“…Onset, progression, and distribution vary considerably among individuals and genetic subtypes, but overall LGMD is similar to Duchenne and Becker muscular dystrophy in sleep manifestations. SDB appears due to both central sleep apnea on account of failure of respiratory control, and obstructive sleep apnea due to upper airway muscles weakness (49). LGMD patients with SDB should be treated with nocturnal NIPV, and tracheostomy ventilation is rarely required.…”

Section: Myopathiesmentioning

confidence: 99%

“…Sleep is disrupted by central sleep apnea/hypopnea due to a central ventilatory control disorder, or by obstructive sleep apnea/hypopnea resulting from upper airway muscle weakness (49). Respiratory muscle atonia during REM sleep may cause nocturnal desaturation and hypoventilation.…”

Section: Myopathiesmentioning

confidence: 99%

Neuromuscular Disorders and Sleep in Critically Ill Patients

Irfan

Selim

Rabinstein

et al. 2015

Critical Care Clinics

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Synopsis Sleep-disordered breathing (SDB) is a frequent presenting manifestation of neuromuscular disorders and can lead to significant morbidity and mortality. If not promptly recognized and addressed early in the clinical course, SDB can lead to clinical deterioration with respiratory failure. In this article, we review the pathophysiologic basis of SDB in neuromuscular disorders, clinical features encountered in specific neuromuscular diseases, and diagnostic and management strategies for SDB in neuromuscular patients in the critical care setting. Non-invasive positive pressure ventilation (NIPV) has been a crucial advance in critical care management, improving sleep quality and often preventing or delaying mechanical ventilation and improving survival in neuromuscular patients.

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Sleep-disordered breathing in children with congenital muscular dystrophies

Cited by 24 publications

References 29 publications

Obstructive sleep disordered breathing in 2- to 18-year-old children: diagnosis and management

Obstructive sleep disordered breathing in 2- to 18-year-old children: diagnosis and management

The Value of Respiratory Muscle Testing in Children With Neuromuscular Disease

Neuromuscular Disorders and Sleep in Critically Ill Patients

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