Sleep disturbance in post COVID-19 conditions: Prevalence and quality of life

Tedjasukmana, Rimawati; Budikayanti, Astri; Islamiyah, Wardah Rahmatul; Witjaksono, Anastasia Melissa Ayu Larasati; Hakim, Manfaluthy

doi:10.3389/fneur.2022.1095606

Cited by 37 publications

(25 citation statements)

References 61 publications

(74 reference statements)

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“…The abnormal values on the Insomnia Severity indices during the post-COVID-19 syndrome phase pointed toward an increase in insomnia symptoms that significantly reduced the quality of life for the affected individuals [ 82 ]. As discussed earlier, the existence of a strong interdependent relationship between mental health and the development of sleep dysfunction plays a vital role in insomnia evolution during the post-COVID-19 phase [ 19 , 83 , 84 , 85 ].…”

Section: How Did Covid-19 Affect Sleep: Related Mechanismsmentioning

confidence: 99%

COVID-19 and Sleep Disturbances: A Literature Review of Clinical Evidence

et al. 2023

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The need for adequate good quality sleep to optimally function is well known. Over years, various physical, psychological, biological, and social factors have been investigated to understand their impact on sleep. However, understanding the etiological processes that are involved in causing sleep disturbances (SD) as impacted by stressful phases such as pandemics has not been well studied. Many such etiological and management strategies have surfaced during the latest “coronavirus disease of 2019 (COVID-19) pandemic. The occurrence of these SD in the infected and uninfected individuals poses a need to investigate factors linked to such occurrence during this phase. Some of such factors include stressful practices such as social distancing, masking, vaccines, and medications availability, changes in routines, and lifestyles. As the status of infection improved, a collective term for all the prolonged effects of COVID-19 after the resolution of the primary infection called the post-COVID-19 syndrome (PCS) surfaced. Apart from impacting sleep during the infectious phase, the aftereffects of this virus left an even greater impact during the PCS. Various mechanisms have been hypothesized to be linked to such SD during the PCS, but the available data are inconclusive. Further, the varied patterns of incidence of these SDs differed by many factors, such as age, gender, and geographical location, making clinical management even more challenging. This review elucidates the impact of coronavirus 2 (SARS-CoV-2) (COVID) disease on sleep health during the various phases of the COVID-19 pandemic. We also investigate different causal relationships, management strategies, and knowledge gaps related to SD during the COVID-19 pandemic.

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Section: How Did Covid-19 Affect Sleep: Related Mechanismsmentioning

confidence: 99%

COVID-19 and Sleep Disturbances: A Literature Review of Clinical Evidence

et al. 2023

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“…Recent studies have shown that HRW intake has a positive effect on metabolism and aids in improving sleep quality while increasing neuronal activity in sleep-related brain regions [40,41]. During persistent inflammation induced by Long COVID, the neurons in the sleep-regulating area of the brain may be damaged, which can negatively affect circadian rhythm [42]. Therefore, HRW intake may reduce difficulty sleeping by regulating the nervous system and affecting nerve activity in sleep-regulatory regions.…”

Section: Discussionmentioning

confidence: 99%

The Effect of 14-Day Consumption of Hydrogen-Rich Water Alleviates Fatigue but Does Not Ameliorate Dyspnea in Long-COVID Patients: A Pilot, Single-Blind, and Randomized, Controlled Trial

Tan,

Xie,

Dong

et al. 2024

Nutrients

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(1) Background: Hydrogen (H2) may be a potential therapeutic agent for managing Long COVID symptoms due to its antioxidant and anti-inflammatory properties. However, more scientific literature is needed to describe the effects of H2 administration on treating symptoms. A study aimed to investigate the impact of hydrogen-rich water (HRW) administration on the fatigue and dyspnea of Long-COVID patients for 14 consecutive days. (2) Methods: In this randomized, single-blind, placebo-controlled study, 55 participants were recruited, and 23 of them were excluded. A total of 32 eligible participants were randomized into a hydrogen-rich water (HRW) group (n = 16) and a placebo water (PW) group (n = 16) in which they were instructed to consume hydrogen-rich water or placebo water for 14 days, respectively. The participants completed the Fatigue Severity Scale (FSS), Six-Minute Walk Test (6MWT), 30 s Chair Stand Test (30s-CST), Modified Medical Research Council Dyspnea Rating Scale (mMRC), Pittsburgh Sleep Quality Index (PSQI), and depression anxiety stress scale (DASS-21) before and after the intervention. A linear mixed-effects model was used to analyze the effects of HRW. Cohen’s d values were used to assess the effect size when significance was observed. The mean change with 95% confidence intervals (95% CI) was also reported. (3) Results: The effects of HRW on lowering FSS scores (p = 0.046, [95% CI = −20.607, −0.198, d = 0.696] and improving total distance in the 6WMT (p < 0.001, [95% CI = 41.972, 61.891], d = 1.010), total time for the 30s-CST (p = 0.002, [95% CI = 1.570, 6.314], d = 1.190), and PSQI scores (p = 0.012, [95% CI = −5.169, 0.742], d = 1.274) compared to PW were of a significantly moderate effect size, while there was no significant difference in mMRC score (p = 0.556) or DASS-21 score (p > 0.143). (4) Conclusions: This study demonstrates that HRW might be an effective strategy for alleviating fatigue and improving cardiorespiratory endurance, musculoskeletal function, and sleep quality. Still, it does not ameliorate dyspnea among Long-COVID patients.

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“…It can be assumed that, in the treatment of respondents with post-COVID-19 sleep disorder, circadian technology was not implemented (Pyatin, 2018 ). In addition, individuals who recovered from COVID-19 had a later chronotype than those without a history of COVID-19 (Han et al, 2023 ; Tedjasukmana et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, sleep disorders have been associated with patients who have been infected with SARS-CoV-2 as a result of the infection, and it has been documented that these disorders can worsen the severity of the infection, reducing the quality of life of the patient in the process. Tedjasukmana et al ( 2023 ) conducted an online survey of the condition following COVID-19 in different countries, which found that 78.58% of respondents had sleep disorders, including insomnia, sleep breathing disorders, hypersomnolence, sleep-wake circadian rhythm disorders, parasomnia, and sleep-related movements. As a result, several SF-36 quality-of-life parameters were statistically significant positive predictors of moderate to severe insomnia in the SF-36 scale.…”

Section: Introductionmentioning

confidence: 99%

Comparative study of quality of life 9 months post-COVID-19 infection with SARS-CoV-2 of varying degrees of severity: impact of hospitalization vs. outpatient treatment

et al. 2023

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PurposeThis experimental study was conducted during the post-COVID-19 period to investigate the relationship between the quality of life 9 months after and the severity of the SARS-CoV-2 infection in two scenarios: hospitalization (with/without medical oxygen) and outpatient treatment.MethodsWe employed the EQ-5D-5L Quality of Life tests and the PSQI as a survey to evaluate respondents' quality of life 9 months after a previous SARS-CoV-2 infection of varying severity.ResultsWe identified a clear difference in the quality of life of respondents, as measured on the 100-point scale of the EQ-5D-5L test, which was significantly lower 9 months after a previous SARS-CoV-2 infection for Group 1 (n = 14), respondents who had received medical attention for SARS-CoV-2 infection in a hospital with oxygen treatment, compared to those with the SARS-CoV-2 infection who were treated without oxygen treatment (Group 2) (n = 12) and those who were treated on an outpatient basis (Group 3) (n = 13) (H = 7.08 p = 0.029). There were no intergroup differences in quality of life indicators between hospitalized patients (Group 2) and groups 1 and 3. PSQI survey results showed that “mobility,” “self-care,” “daily activities,” “pain/discomfort,” and “anxiety/ depression” did not differ significantly between the groups, indicating that these factors were not associated with the severity of the SARS-CoV-2 infection. On the contrary, the respondents demonstrated significant inter-group differences (H = 7.51 p = 0.023) and the interdependence of respiratory difficulties with the severity of clinically diagnosed SARS-CoV-2 infection. This study also demonstrated significant differences in the values of sleep duration, sleep disorders, and daytime sleepiness indicators between the three groups of respondents, which indicate the influence of the severity of the infection. The PSQI test results revealed significant differences in “bedtime” (H = 6.00 p = 0.050) and “wake-up time” (H = 11.17 p = 0.004) between Groups 1 and 3 of respondents. At 9 months after COVID-19, respondents in Group 1 went to bed at a later time (pp = 0.02727) and woke up later (p = 0.003) than the respondents in Group 3.ConclusionThis study is the first of its kind in the current literature to report on the quality of life of respondents 9 months after being diagnosed with COVID-19 and to draw comparisons between cohorts of hospitalized patients who were treated with medical oxygen vs. the cohorts of outpatient patients. The study's findings regarding post-COVID-19 quality of life indicators and their correlation with the severity of the SARS-CoV-2 infection can be used to categorize patients for targeted post-COVID-19 rehabilitation programs.

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Sleep disturbance in post COVID-19 conditions: Prevalence and quality of life

Cited by 37 publications

References 61 publications

COVID-19 and Sleep Disturbances: A Literature Review of Clinical Evidence

COVID-19 and Sleep Disturbances: A Literature Review of Clinical Evidence

The Effect of 14-Day Consumption of Hydrogen-Rich Water Alleviates Fatigue but Does Not Ameliorate Dyspnea in Long-COVID Patients: A Pilot, Single-Blind, and Randomized, Controlled Trial

Comparative study of quality of life 9 months post-COVID-19 infection with SARS-CoV-2 of varying degrees of severity: impact of hospitalization vs. outpatient treatment

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