Sleep Disturbances and Correlates of Children with Autism Spectrum Disorders

Liu, Xianchen; Hubbard, Julie A.; Fabes, Richard A.; Adam, James B.

doi:10.1007/s10578-006-0028-3

Cited by 295 publications

(209 citation statements)

References 26 publications

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“…This study supports previous evidence from children with autism that indicates increased sleep difficulties for that group (Mannion & Leader, 2014;Goldman et al, 2011;Mannion, Leader & Healy, 2013;Liu, Hubbard, Richard & Adam, 2006). However, it is to our knowledge one of the first to document sleep behaviours in children with language impairment, and to look at the relationship between language and sleep in either population.…”

Section: Discussionsupporting

confidence: 88%

Sleep behaviour relates to language skills in children with and without communication disorders

Botting

Baraka

2017

International Journal of Developmental Disabilities

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This is the accepted version of the paper.This version of the publication may differ from the final published version. OBJECTIVES: The aims of this study were to: i) compare sleep patterns of children with communication disorders to the sleep patterns of their typical peers, and ii) ascertain whether sleep patterns related to language in this sample. Permanent repository link METHOD:The relationship between sleep and language was investigated via parental questionnaires. There were sixty-five child participants in total aged between 3-18 years.Parents reported on 28 children with a developmental communication disorder (CD; ASD n=8 or DLD n=20) and 37 who were typical developing.RESULTS: The children with a developmental communication disorder showed more sleep problems than their typical peers particularly in terms of getting to sleep and early waking. Furthermore, significant correlations were found between sleep behaviour and language for children in both groups.CONCLUSION: Children with CD may have poorer sleep patterns than their typical peers which could compound developmental language difficulties.

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Section: Discussionsupporting

confidence: 88%

Sleep behaviour relates to language skills in children with and without communication disorders

Botting

Baraka

2017

International Journal of Developmental Disabilities

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“…This problem persists through childhood because 50-80% of children with ASD show highly significant increased sleep latency and nocturnal awakenings (Richdale and Prior 1995;Taira et al 1998;Takase et al 1998;Hering et al 1999;Elia et al 2000;Hayashi 2000;Schreck and Mulick 2000;Gail Williams et al 2004;Wiggs and Stores 2004;Limoges et al 2005;Oyane and Bjorvatn 2005;Polimeni et al 2005;Allik et al 2006;Hare et al 2006;Liu et al 2006;Malow et al 2006). An extensive survey of the sleep problems observed in ASD was recently reported by Liu et al (2006). In their cohort of 167 children (age 8.8 ± 4.2, 86% males), 86% had at least one sleep problem almost everyday, including 54% with bedtime resistance, 56% with insomnia, 53% with parasomnias, 25% with sleep disordered breathing, 45% with morning rise problems, and 31% with daytime sleepiness.…”

Section: Atypical Sleep and Circadian Rhythms In Autism Spectrum Disomentioning

confidence: 99%

The Possible Interplay of Synaptic and Clock Genes in Autism Spectrum Disorders

Bourgeron¹

2007

Cold Spring Harbor Symposia on Quantitative Biology

165

124

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Autism spectrum disorders (ASD) are complex neurodevelopmental conditions characterized by deficits in social communication, absence or delay in language, and stereotyped and repetitive behaviors. Results from genetic studies reveal one pathway associated with susceptibility to ASD, which includes the synaptic cell adhesion molecules NLGN3, NLGN4, and NRXN1 and a postsynaptic scaffolding protein SHANK3. This protein complex is crucial for the maintenance of functional synapses as well as the adequate balance between neuronal excitation and inhibition. Among the factors that could modulate this pathway are the genes controlling circadian rhythms. Indeed, sleep disorders and low melatonin levels are frequently observed in ASD. In this context, an alteration of both this synaptic pathway and the setting of the clock would greatly increase the risk of ASD. In this chapter, I report genetic and neurobiological findings that highlight the major role of synaptic and clock genes in the susceptibility to ASD. On the basis of these lines of evidence, I propose that future studies of ASD should investigate the circadian modulation of synaptic function as a focus for functional analyses and the development of new therapeutic strategies.

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“…The nature of the problems can vary but may largely consist of difficulties in falling asleep or sleep latency [Allik et al, 2006;Liu et al, 2006]. Perhaps more than the other potentially emergent phenomena, sleep problems may usually represent a difference in degree rather than kind.…”

Section: Sleep Problemsmentioning

confidence: 99%

The potential role for emergence in autism

Anderson

2008

Autism Research

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Although most research on autistic behavior has considered autism categorically, the increasingly apparent genetic and phenotypic complexities of autism are prompting a more dimensional approach to this area. The long-standing interest in a less categorical approach is made clear from a review of literature. The accumulating empirical support for viewing autism-related phenomena as separable and fractionable is outlined and includes data indicating that many of the behaviors occur in isolation in family members and the general population, are not highly correlated within individuals, and appear to be inherited separately. However, it is emphasized that some of the most common and characteristic phenomena observed in individuals diagnosed with autism do not run in their families. It is suggested that these novel, ''emergent,'' phenomena may arise in the individual from interacting configurations of co-occurring traits or from the interaction of genetic and biological factors underlying the traits. A number of autism-related phenomena including intellectual disability, seizures, persistence of primitive reflexes, stereotypies, self-injurious behavior, savant abilities, and morphological abnormalities, among others, are discussed as potentially being emergent. It is concluded that consideration of the role of emergence in autistic behavior and related phenomena should complement a reductionist approach and might help illuminate the components and complexities of autism.

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Sleep Disturbances and Correlates of Children with Autism Spectrum Disorders

Cited by 295 publications

References 26 publications

Sleep behaviour relates to language skills in children with and without communication disorders

Sleep behaviour relates to language skills in children with and without communication disorders

The Possible Interplay of Synaptic and Clock Genes in Autism Spectrum Disorders

The potential role for emergence in autism

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