Sleep duration and the risk of osteoporosis among middle-aged and elderly adults: a dose-response meta-analysis

Wang, D; Ruan, Wenyu; Peng, Ying; Li, W

doi:10.1007/s00198-018-4487-8

Cited by 42 publications

(31 citation statements)

References 35 publications

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“…There was a good correlation between VAS and QUALEFFO-41 in all domains. A similar relationship in women with osteoporosis in Norway was observed by Stanghelle Brita et al [35]. The authors suggest that pain intensity negatively affects HRQoL in women with osteoporosis with or without vertebral fracture [36].…”

Section: Discussionsupporting

confidence: 61%

“…A similar relationship in women with osteoporosis in Norway was observed by Stanghelle Brita et al [35]. The authors suggest that pain intensity negatively affects HRQoL in women with osteoporosis with or without vertebral fracture [36]. Moreover, chronic pain contributes to unbalanced gait, which increases the risk of falls in older people [37].…”

Section: Discussionsupporting

confidence: 54%

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Quality of Life in Women With Postmenopausal Osteoporosis - Pilot Studies in the Łódź Province

Górczewska

Jakubowska-Pietkiewicz²

2020

Preprint

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BackgroundOsteoporosis is a social disease and epidemic of the 21st century, and is also a growing problem in the ageing Polish society. The aim of the study was to assess the quality of life (QoL) in women with postmenopausal osteoporosis. MethodsThe study was an outpatient, questionnaire-based poll, carried out from VI.2018 to V.2019. A group of 198 women, aged 72.31±8.59 years with diagnosed postmenopausal osteoporosis in two Osteoporosis Clinics in the city of Łódź (Poland) were included. The paper uses: the Polish version of the QUALEFFO 41 quality of life scale, the VAS scale and a survey of my own authorship. The data were analysed using multiple linear regression.ResultsThe average result of QUALEFFO-41 was 40.26±16.92 points. Analysing individual QUALEFFO-41 domains the lowest quality of life was found in the mental function domain (mental function 48.49±18.06 points). The visual analogue scale of pain was 4.87±2.39 points. The VAS scale positively correlated with all QUALEFFO 41 domains. Marital status, education and financial situation had a significant statistical impact on the quality of life (p<;0.05). Multiple regression step-by-step analysis showed that pain expressed on the VAS scale, pain awakening from sleep, taking sleeping pills and older age of respondents deteriorate the quality of life.ConclusionThe analysis showed that Polish women with postmenopausal osteoporosis have an average quality of life. In Poland the assessment of quality of life of chronically ill patients and routine evaluation of pain severity on the VAS scale is not common.

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Section: Discussionsupporting

confidence: 61%

Section: Discussionsupporting

confidence: 54%

Quality of Life in Women With Postmenopausal Osteoporosis - Pilot Studies in the Łódź Province

Górczewska

Jakubowska-Pietkiewicz²

2020

Preprint

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“…Human data are limited to mostly cross-sectional studies showing no association [11,12] or that both short [13][14][15][16][17][18][19][20][21][22][23] and long [13][14][15][16][17][24][25][26][27][28][29][30] sleep durations are associated with low BMD (as reviewed in [31]). Of the 20 studies published to date on the association between sleep duration and BMD in humans [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30], women comprised the majority of participants. All studies of men used subjective (self-reported) sleep duration and focused primarily on middle-aged adults when it is older men who are at highest risk of bone loss and fracture, and potential effect modifiers, such as vitamin D status, were not considered.…”

Section: Introductionmentioning

confidence: 99%

Sleep duration and bone health measures in older men

et al. 2020

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The associations between objective measures of sleep duration and bone outcomes in older men are unknown. No consistent, significant association was identified between sleep duration and bone mineral density (BMD) in the current analysis. However, future research should determine if vitamin D status modifies this relationship. Introduction Prior studies, predominantly in women, reported that long and short self-reported sleep duration are associated with lower BMD. Associations between actigraphy-determined sleep duration and BMD or bone turnover markers (BTMs) in older men are unknown. Methods Men in The Osteoporotic Fractures in Men (MrOS) Study with wrist actigraphy and concurrent BMD assessment but without comorbidities affecting bone health were included. Sleep duration was considered as a continuous (N = 1926) and dichotomized variable where men were classified as getting the recommended (7-8 h/night; N = 478) or short (< 6 h/night; N = 577) sleep. The cross-sectional association between BMD, BTMs, and sleep duration was examined using a t test or linear regression, where appropriate, in unadjusted and adjusted models. Results There were no clinically or statistically significant differences in BMD at the L-spine, total hip, or femoral neck between men getting the recommended vs. short sleep duration, using actigraphy or self-reported sleep duration (all p ≥ 0.07). When sleep duration was considered as a continuous variable, femoral neck BMD was higher in men with longer self-reported sleep duration (β = 0.006 ±0.003, p = 0.02), but this was not significant after further adjustment. In men with low 25OHD (< 20 ng/mL), longer actigraphy-determined sleep duration was associated with higher total hip BMD (β = 0.016 ± 0.008; p = 0.04). Sleep duration and BTMs were not associated.

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“…Sleep quality has been proven to decrease with age [3], and insufficient sleep and sleep disorder have been associated with adverse outcomes such as weight gain and obesity, diabetes, inflammation, cardiovascular disease, neurocognitive health, mental health and mortality, and these relationships have been widely discussed in the media [4]. It has also been theorised that sleep duration may be associated with risk of osteoporosis, with previous studies suggesting that insufficient or indeed excessive sleep might affect bone health in middle-aged and elderly adults [5]. However, previous studies have focussed mostly on short sleep duration [5][6][7][8][9][10] and obstructive sleep apnoea [11][12][13][14][15][16] as possible contributors to osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

Self-reported Sleep Quality and Bone Outcomes in Older Adults: Findings from the Hertfordshire Cohort Study

et al. 2020

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Sleep duration may be associated with risk of osteoporosis, with suggestions that too little or indeed too much sleep may be detrimental to bone health. In this study, we considered whether perceived sleep quality is also associated with bone health in older adults. We explored this association in a cohort of 443 older community-dwelling UK adults. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI); poor sleep quality was defined as > 5 on this score system. Bone density, shape and microarchitecture were assessed using dual energy X-ray absorptiometry (DXA), peripheral quantitative computed tomography (pQCT) and high-resolution pQCT (HRpQCT). Thirty-seven percent of men and 43% of women had a PSQI score greater than 5, indicative of poor perceived sleep. We found that quality of sleep was associated with altered bone microarchitecture. In men, poor sleep quality was associated with lower radial trabecular (4% slice, p < 0.04) and cortical (66% slice, p = 0.02) bone mineral density, as well as decreased tibial cortical density (p < 0.02) and increased porosity (p < 0.04), but increased size of the tibia (p < 0.04). In women, poor perceived sleep quality was associated with thinner (p < 0.03) and less dense (p < 0.04) cortices of the radius, but greater tibial trabecular number (p < 0.02) and lower separation (p < 0.04). Relationships with DXA parameters were non-significant after adjustment for confounders. Taking sleep medications was associated with decreased tibial size (38% and 66% slices) and strength in women (all p < 0.05), but not in men. Perceived sleep quality was associated with altered bone density and microarchitecture in older adults, and these differences varied according to biological sex and site. Further work is indicated to investigate possible mechanisms underlying these observations.

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Sleep duration and the risk of osteoporosis among middle-aged and elderly adults: a dose-response meta-analysis

Cited by 42 publications

References 35 publications

Quality of Life in Women With Postmenopausal Osteoporosis - Pilot Studies in the Łódź Province

Quality of Life in Women With Postmenopausal Osteoporosis - Pilot Studies in the Łódź Province

Sleep duration and bone health measures in older men

Self-reported Sleep Quality and Bone Outcomes in Older Adults: Findings from the Hertfordshire Cohort Study

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