Sleep Dysfunction in Japanese Patients with Gastroesophageal Reflux Disease: Prevalence, Risk Factors, and Efficacy of Rabeprazole

Fujiwara, Yasuhiro; Kohata, Yukie; Kaji, M; Nebiki, Hiroko; Yamasaki, Tomoaki; Sasaki, Eiji; Hayakawa, Tsuyoshi; Machida, Hirohisa; Tanigawa, Tetsuya; Watanabe, Kenji; Watanabe, Toshio; Tominaga, Kazunari; Arakawa, Tetsuo

doi:10.1159/000253849

Cited by 35 publications

(40 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, the relationships between sleep disturbances and various abdominal symptoms were evaluated in subjects without organic gastrointestinal disease. Our results showed that GERD-like symptoms, such as heartburn and acid regurgitation, aggravate daytime sleepiness, as previously reported (3)(4)(5)13). However, the presence of GERDlike symptoms was not found to have a statistically significant effect on the incidence of sleep disturbances (ESS score !…”

Section: Discussionsupporting

confidence: 85%

“…and it may be disturbed by gastrointestinal symptoms. Reflux symptoms, including heartburn and acid regurgitation, that occur during the nocturnal period have been repeatedly reported to impair sleep quality (3)(4)(5)(6), and GERD is regarded to be a disease with nocturnal symptoms that must be completely eliminated in order to relieve sleep disturbances (13). In the present study, the relationships between sleep disturbances and various abdominal symptoms were evaluated in subjects without organic gastrointestinal disease.…”

Section: Discussionmentioning

confidence: 96%

“…Patients with gastroesophageal reflux disease (GERD) are reported to have a decreased quality of sleep due to heartburn and/or acid regurgitation disturbances (1,2). Indeed, treatment of GERD with the administration of a proton pump inhibitor (PPI) has been shown to improve not only reflux symptoms, but also sleep quality (3)(4)(5)(6). However, the effects of abdominal symptoms other than heartburn and acid regurgitation on sleep have not been thoroughly investigated.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association between Sleep Disturbances and Abdominal Symptoms

et al. 2014

View full text Add to dashboard Cite

Objective Although gastroesophageal reflux disease (GERD) is known to cause sleep disturbances, the relationships between other abdominal symptoms and sleep disorders have not been clarified. In the present study, we examined the relationships between daytime sleepiness and various abdominal symptoms in a nonclinical population. Methods We enrolled 2,936 subjects who visited Matsue Red Cross Hospital for an annual health check examination during a 10-month consecutive period after excluding those with organic gastrointestinal diseases. The Izumo scale abdominal symptom and Epworth Sleepiness Scale (ESS) questionnaires were employed to evaluate the presence of abdominal symptoms and daytime sleepiness. Results Among the 2,936 subjects, 233 (7.9%), 254 (8.6%) and 528 (18%) had GERD-like, functional dyspepsia (FD)-like and irritable bowel syndrome (IBS)-like symptoms, respectively. The ESS scores in the subjects with GERD-, FD-and IBS-like symptoms were significantly higher than those observed in the asymptomatic subjects. The subjects with multiple abdominal symptoms tended to have higher ESS scores than those with single symptoms. A multiple logistic regression analysis revealed a younger age and the presence of FD-and IBS-like symptoms to be significant influencing factors for sleep disturbances. Conclusion The presence of FD and IBS symptoms in addition to GERD symptoms exhibits a strong relationship with sleep disturbances from the viewpoint of daytime sleepiness.

show abstract

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association between Sleep Disturbances and Abdominal Symptoms

et al. 2014

View full text Add to dashboard Cite

show abstract

“…For example, Fujiwara et al examined the effects of rabeprazole at a dose of 10 mg for eight weeks on sleep disturbances in 134 patients with GERD who subsequently completed the PSQI. The authors found that 52% of the patients with GERD had sleep disturbances and that PPI treatment significantly improved the PSQI scores (6). Another study showed that twice daily treatment with rabeprazole for four to eight weeks significantly reduced the frequency of nighttime reflux symptoms, arousals due to nighttime reflux symptoms during sleep, daytime sleepiness and poor sleep quality in patients refractory to once daily standard PPI treatment (26).…”

Section: Discussionmentioning

confidence: 99%

“…The goal of GERD treatment is to al-with non-erosive reflux disease are highly affected by sleep disturbances in Japan (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Effects of Esomeprazole on Sleep in Patients with Gastroesophageal Reflux Disease as Assessed on Actigraphy

Hiramoto

Fujiwara

Ochi³

et al. 2015

Intern. Med.

Self Cite

View full text Add to dashboard Cite

Objective Gastroesophageal reflux disease (GERD) is strongly associated with sleep disturbances. Although treatment with proton pump inhibitors (PPIs) helps to improve GERD symptoms and subjective sleep parameters, the effects of PPI therapy on objective sleep parameters are conflicting. The aim of this study was to examine the effects of esomeprazole treatment on GERD symptoms and sleep parameters assessed using actigraphs and questionnaires. Methods Thirteen patients with GERD received 20 mg of esomeprazole once daily for two weeks. The patients wore actigraphs from three days before the initiation of PPI treatment to the end of therapy. They were also asked to answer the following self-reported questionnaires: Frequency Scale for the Symptoms of GERD (FSSG), Pittsburg Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS). Objective sleep parameters were evaluated using actigraphy. Results Treatment with esomeprazole significantly decreased the total FSSG score, including the scores for reflux and dysmotility, as well as the ESS score, although it had no effect on the PSQI score. After the second week of treatment, esomeprazole significantly decreased the wake time (from 47.5±39.6 min to 36.0± 27.1 min) and sleep latency period (from 19.5±19.8 min to 9.9±10.2 min) and increased the percentage of sleep time (from 89.1±8.8% to 91.9±6.3%); however, improvements were not noted in all objective parameters. Conclusion Esomeprazole treatment significantly improves various objective sleep parameters in Japanese patients with GERD. Further placebo-controlled randomized trials are needed to obtain detailed results.

show abstract