Sleep laboratory adaptation in normal subjects and depressed patients (“first night effect”)

Mendels, J.; Hawkins, David R.

doi:10.1016/0013-4694(67)90063-6

Cited by 120 publications

(57 citation statements)

References 3 publications

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“…36 Also, studies reporting a RFNE in insomniacs have largely excluded patients with significant psychiatric illnesses such as depression; however, it has been shown that insomnia and depression are frequently comorbid conditions, with over 90% of depressed patients suffering from sleep complaints. 21,22 Some studies on first night adaptation effects in depressed patients have observed a reduced or absent FNE 2,9,23 ; however, it is unknown whether patients suffering from both insomnia and depression exhibit similar laboratory adaptation effects as those suffering from only one of these disorders.…”

Section: Psgmentioning

confidence: 99%

“…This "fi rst night effect" (FNE) is typically characterized by increased sleep onset latency, increased REM latency, a lower percentage of REM stage sleep, and lower sleep effi ciency as measured by polysomnography (PSG). While many studies have observed the FNE phenomenon in normal subjects and in those with depression or insomnia, [1][2][3] others have observed a reduced or absent FNE. [4][5][6] It has been suggested that factors such as the location of monitoring or pleasantness of the laboratory environment may attenuate this effect, or that individual variability may cancel out differences for entire samples.…”

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confidence: 99%

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Objective vs. Subjective Measurements of Sleep in Depressed Insomniacs: First Night Effect or Reverse First Night Effect?

McCall

2012

Journal of Clinical Sleep Medicine

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Study Objectives: This study examined changes in sleep parameters between the laboratory and the home setting before and after laboratory monitoring in depressed insomniacs undergoing treatment. Methods: This study was a post hoc analysis of a double-blind, randomized, placebo-controlled clinical trial performed with 60 depressed, insomniac outpatients. Patients underwent actigraphic monitoring along with sleep diaries over a continuous 2-week period. After one week of baseline monitoring, subjects spent one night in the laboratory with concurrent actigraphic and PSG monitoring with sleep diaries. Actigraphic monitoring and sleep diaries were continued for another week at home, along with initiation of open-label fl uoxetine (FLX). Results: Actigraphically recorded laboratory sleep during the night in the laboratory was found to be improved relative to actigraphically recorded sleep at home, with less wake time and greater sleep time and sleep effi ciency occurring in the laboratory. In contrast, sleep diaries indicated a slight worsening of sleep in the laboratory compared to home, with signifi cantly more awakenings in the laboratory compared to the week at home before and after the laboratory night. Conclusions S C I E N T I F I C I N V E S T I G A T I O N SM any individuals experience worse sleep during their fi rst night in a sleep laboratory than on successive nights. This "fi rst night effect" (FNE) is typically characterized by increased sleep onset latency, increased REM latency, a lower percentage of REM stage sleep, and lower sleep effi ciency as measured by polysomnography (PSG). While many studies have observed the FNE phenomenon in normal subjects and in those with depression or insomnia, 1-3 others have observed a reduced or absent FNE. [4][5][6] It has been suggested that factors such as the location of monitoring or pleasantness of the laboratory environment may attenuate this effect, or that individual variability may cancel out differences for entire samples. 5,7-10Many studies observing a FNE have also noted a "paradoxical" or "reverse" fi rst night effect (RFNE) in some of their subjects.11-14 The RFNE is characterized by the observation of decreased sleep onset latency, decreased REM latency, a higher percentage of REM, and greater sleep effi ciency in the fi rst night at the laboratory relative to successive nights, as measured by PSG.13 For insomniacs who demonstrate this phenomenon, several explanations have been proposed. Hauri et al. suggested that maladaptive reinforcements are formed between the insomniac's sleeping problems and their normal sleep environment. 13,15 This conditioned arousal reaction to their normal sleep environment does not generalize to the novel sleep environment of the laboratory, where they fall asleep more easily. Alternatively, de la Pena proposed that some insomniacs require a higher level of waking sensory stimulation to induce sleep, and the greater sensory stimulation of the novel laboratory environment improves their sleep. 16Studies investigating sleep ...

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Section: Psgmentioning

confidence: 99%

mentioning

confidence: 99%

Objective vs. Subjective Measurements of Sleep in Depressed Insomniacs: First Night Effect or Reverse First Night Effect?

McCall

2012

Journal of Clinical Sleep Medicine

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“…Because of the observed differences between the first and the consecutive night spent in the sleep laboratory, it is common practice to exclude the first-night recording from any polysomnographic analysis (Mendels & Hawkins, 1967). Although most differences have been observed by comparing the first and the second night, it has also been shown that residual effects are present beyond the second night (Le Bon et al, 2001), and this can question the validity of the data recorded even on the second night.…”

mentioning

confidence: 99%

“…Despite these limitations, our results draw attention to the fact that, in contrast to everyday practice-according to which the polysomnographic data recorded at the first night spent in the laboratory has to be excluded (Mendels & Hawkins, 1967)-the analysis of the first night's sleep can provide valuable information. The differences between the sleep macrostructure of the first and second night are not necessarily the same in different medical conditions; therefore, future research about this phenomena might shed light on new diagnostic criteria.…”

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confidence: 99%

Objective and Subjective Components of the First-Night Effect in Young Nightmare Sufferers and Healthy Participants

Kis

Szakadát

Simor³

et al. 2013

Behavioral Sleep Medicine

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“…39 It is possible that in a 1-night PSG, the results are influenced by a first-night effect. 40,41 However, such an effect should similarly affect the sleep of HC. The scoring of PSG in patients with IPD is a demanding task, as disease-inherent sleep fragmentation, abrupt sleep-wakefulness transitions, and further electroencephalographic abnormalities may occur.…”

Section: Discussionmentioning

confidence: 99%

Reduced Rapid Eye Movement Density in Parkinson Disease: A Polysomnography-Based Case-Control Study

Schroeder

Rufra

Sauvageot

et al. 2016

Sleep

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Study Objectives: To explore rapid eye movement density (RD) in patients with idiopathic Parkinson disease (IPD) and to investigate its usefulness as surrogate marker of excessive daytime sleepiness, a frequent complaint in IPD patients. Methods: Retrospective polysomnography study on 81 subjects without dementia: 29 patients with early stage IPD (disease duration ≤ 3 y), 21 patients with middle-stage IPD (disease duration > 3 and < 8 y) and 31 healthy controls (HC). Rapid eye movement (REM) sleep was defined as any REM episode with > 3 min of continuous REM sleep. RD was defined as number of ocular movements per minute of REM sleep. Patients with early stage IPD and HC fulfilled the PDspecific sleepiness questionnaires Parkinson's Disease Sleep Scale (PDSS) and the Nonmotor Symptoms Questionnaire for Parkinson's disease (NMSQuest). Results: RD was lower in patients with IPD than in HC. The difference was most significant between patients with middle stage IPD and HC (P = 0.001), and most prominent for the third REM episode, again when comparing patients with middle stage IPD and HC (P = 0.03). RD was independent from sex, age, and other sleep parameters. In early stage IPD, RD correlated with the PDSS score (r = −0.63, P = 0.001) and the sleep-related questions of the NMSQuest score (r = 0.48, P = 0.017). Conclusions: REM density is reduced in patients with IPD and correlates with subjective scores on sleep impairment. As an indicator of persistent high sleep pressure, reduced RD in IPD is eligible as a biomarker of excessive daytime sleepiness in IPD. It possibly reflects direct involvement of the brainstem REM generation sites by the disease process. RD is a promising new tool for sleep research in IPD.

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Sleep laboratory adaptation in normal subjects and depressed patients (“first night effect”)

Cited by 120 publications

References 3 publications

Objective vs. Subjective Measurements of Sleep in Depressed Insomniacs: First Night Effect or Reverse First Night Effect?

Objective vs. Subjective Measurements of Sleep in Depressed Insomniacs: First Night Effect or Reverse First Night Effect?

Objective and Subjective Components of the First-Night Effect in Young Nightmare Sufferers and Healthy Participants

Reduced Rapid Eye Movement Density in Parkinson Disease: A Polysomnography-Based Case-Control Study

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