Sleep Laboratory Diagnosis of Restless Legs Syndrome

Michaud, Martin; Paquet, Jean; Lavigne, Gilles; Désautels, Alex; Montplaisir, Jacques

doi:10.1159/000062996

Cited by 125 publications

(62 citation statements)

References 16 publications

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“…Generally, PLMS have been found in approximately 80-90% of patients with RLS (37,38) and previously, PLMS was associated with sleep disruption in MS (39). Neurophysiological examination, such as polysomnography, is essential for the diagnosis of PLMS and can contribute to diagnosis in uncertain RLS cases.…”

Section: Discussionmentioning

confidence: 94%

Restless leg syndrome, sleep quality and fatigue in multiple sclerosis patients

Moreira

Damasceno

Medeiros

et al. 2008

Braz J Med Biol Res

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27), quality of sleep by the Pittsburgh Sleep Quality Index (PSQI >6), excessive daytime sleepiness by the Epworth Sleepiness Scale (ESS >10) and clinical disability by the Expanded Disability Status Scale (EDSS). Forty-four patients (32 women) aged 14 to 64 years (43 ± 14) with disease from 0.4 to 23 years (6.7 ± 5.9) were evaluated. Thirty-five were classified as relapsing-remitting, 5 as primary progressive and 4 as secondary progressive. EDSS varied from 0 to 8.0 (3.6 ± 2.0). RLS was detected in 12 cases (27%). Patients with RLS presented greater disability (P = 0.01), poorer sleep (P = 0.02) and greater levels of fatigue (P = 0.03). Impaired sleep was present in 23 (52%) and excessive daytime sleepiness in 3 cases (6.8%). Fatigue was present in 32 subjects (73%) and was associated with clinical disability (P = 0.000) and sleep quality (P = 0.002). Age, gender, disease duration, MS pattern, excessive daytime sleepiness and the presence of upper motor neuron signs were not associated with the presence of RLS. Fatigue was best explained by clinical disability and poor sleep quality. Awareness of RLS among health care professionals may contribute to improvement in MS management.]]>

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Section: Discussionmentioning

confidence: 94%

Restless leg syndrome, sleep quality and fatigue in multiple sclerosis patients

Moreira

Damasceno

Medeiros

et al. 2008

Braz J Med Biol Res

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“…37,39 The suggested immobilization test (SIT) was also developed to quantify subjective leg discomfort and objective leg movement and has a high sensitivity and specificity for diagnosing RLS. 40 The SIT is performed during a 1-hour period prior to bedtime. 41 Leg movements are quantified via surface electromyography from anterior tibialis muscles, and leg discomfort is measured via a visual analog scale.…”

Section: Diagnosis Of Rlsmentioning

confidence: 99%

Mood Disorders in Restless Legs Syndrome (Willis-Ekbom Disease)

Becker¹,

Sharon²

2014

J. Clin. Psychiatry

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Study Selection: 173 publications were retrieved. Articles related to the association between idiopathic RLS and depression, anxiety, and mood disorders were reviewed. In total, 32 epidemiologic studies were identified. These studies were reviewed in detail and ranked according to quality.Data Extraction: Data were extracted on the basis of relevance to the topic. Epidemiologic studies were assessed using 3 parameters: methodology, data quality, and generalizability of the results. Each factor was scored from 1 (high quality) to 4 (low quality), giving a total score of between 3 and 12 for each study.Results and Conclusions: RLS and mood disorders are frequently comorbid. Recognition and appropriate treatment of comorbid RLS are particularly important in patients with psychiatric disorders, as RLS is a common medical reason for insomnia, and antidepressant use may exacerbate sensory symptoms.

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“…Indeed, the principal sleep abnormality seen in RLS is a reduction in the amount of stage 2 sleep, as PLMS are most marked during sleep stages 1 and 2 [21]. PLM may also occur during waking hours (PLMW), delaying the onset of sleep [22].…”

Section: Effects On Sleep and Cognitive Functionmentioning

confidence: 99%

“…Prof. Trenkwalder discusses the pharmacological management of RLS and the extensive ropinirole clinical trial programme elsewhere in this supplement (pp. [21][22][23][24][25][26][27][28][29][30].…”

Section: The Case For Treatmentmentioning

confidence: 99%

Time to REST: epidemiology and burden

Garcı́a-Borreguero¹

2006

Euro J of Neurology

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Restless legs syndrome (RLS) is a neurological disorder characterized by a compelling urge to move, accompanied by disturbing sensations within the legs. It is now recognized that RLS is a common condition that has a substantial impact on sleep, daily activities and quality of life. Recent data from the REST (RLS Epidemiology, Symptoms, and Treatment) general population study show that symptoms of RLS are present in approximately 7% of the general population, and that 2-3% experience moderate or severe symptoms at least twice a week. Amongst this RLS cohort, approximately 88% reported sensory disturbances and 76% reported sleep-related symptoms. These symptoms had a marked effect on everyday life, with up to 50% of the RLS cohort reporting disruption of everyday activities or personal relationships. Sleep disturbances in turn lead to impaired daytime functioning. RLS is associated with a significant impairment of quality of life, comparable with that seen in chronic medical conditions such as diabetes or depression. Given the significant burden of morbidity associated with RLS, there is a strong case for treatment in patients with troublesome symptoms.

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Sleep Laboratory Diagnosis of Restless Legs Syndrome

Cited by 125 publications

References 16 publications

Restless leg syndrome, sleep quality and fatigue in multiple sclerosis patients

Restless leg syndrome, sleep quality and fatigue in multiple sclerosis patients

Mood Disorders in Restless Legs Syndrome (Willis-Ekbom Disease)

Time to REST: epidemiology and burden

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