Sleep Outcomes for Parents of Children With Neurodevelopmental Disabilities: A Systematic Review

Micsinszki, Samantha; Ballantyne, Marilyn; Cleverley, Kristin; Green, Pamela; Stremler, Robyn

doi:10.1177/1074840718773381

Cited by 20 publications

(15 citation statements)

References 84 publications

(116 reference statements)

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“…Recently, our laboratory focused on the association between tryptophan metabolites and neurodevelopmental disorders because of recent studies reporting that patients with neurodevelopmental disorders often have a history of fatigue, daytime tiredness, and daytime sleepiness. 30,128-130 Our previous study demonstrated that autistic symptoms were correlated with higher levels of 3-methoxy-4-hydroxyphenylglycol and lower levels of 5-hydroxyindoleacetic acid, 131 suggesting that dynamic changes in the levels of tryptophan metabolites may be associated with symptoms of neurodevelopmental disorders, including sleep disturbances and fatigue.…”

Section: Tryptophan Metabolites and Fatigue Associated With Neurodevementioning

confidence: 98%

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Potential Role of Neuroactive Tryptophan Metabolites in Central Fatigue: Establishment of the Fatigue Circuit

Yamashita

2020

Int J�Tryptophan�Res

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Central fatigue leads to reduced ability to perform mental tasks, disrupted social life, and impaired brain functions from childhood to old age. Regarding the neurochemical mechanism, neuroactive tryptophan metabolites are thought to play key roles in central fatigue. Previous studies have supported the “tryptophan-serotonin enhancement hypothesis” in which tryptophan uptake into extensive brain regions enhances serotonin production in the rat model of exercise-induced fatigue. However, serotonin was transiently released after 30 minutes of treadmill running to exhaustion, but this did not reflect the duration of fatigue. In addition, as the vast majority of tryptophan is metabolized along the kynurenine pathway, possible involvement of the tryptophan-kynurenine pathway in the mechanism of central fatigue induction has been pointed out. More recently, our study demonstrated that uptake of tryptophan and kynurenine derived from the peripheral circulation into the brain enhances kynurenic acid production in rat brain in sleep deprivation–induced central fatigue, but without change in serotonin activity. In particular, dynamic change in glial-neuronal interactive processes within the hypothalamus-hippocampal circuit causes central fatigue. Furthermore, increased tryptophan-kynurenine pathway activity in this circuit causes reduced memory function. This indicates a major potential role for the endogenous tryptophan-kynurenine pathway in central fatigue, which supports the “tryptophan-kynurenine enhancement hypothesis.” Here, we review research on the basic neuronal mechanism underlying central fatigue induced by neuroactive tryptophan metabolites. Notably, these basic findings could contribute to our understanding of latent mental problems associated with central fatigue.

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Section: Tryptophan Metabolites and Fatigue Associated With Neurodevementioning

confidence: 98%

“…Fatigue is often observed in patients suffering from bone fracture, 9 cancer, 26 coronary heart disease, 27 stroke, 28 depression, 29 and neurodevelopmental disorders. 30 Thus, most of us experi-ence fatigue and it may delay recovery from various pathological conditions.…”

Section: Fatigue-related Brain Changesmentioning

confidence: 99%

Potential Role of Neuroactive Tryptophan Metabolites in Central Fatigue: Establishment of the Fatigue Circuit

Yamashita

2020

Int J�Tryptophan�Res

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“…Sleep quality for caregivers of children with neurodevelopmental disabilities, including CP, is poorer than caregivers of typically developing children (Micsinszki et al, 2018). Adequate sleep is fundamental for good psychological health, and therefore, for caregivers, poor sleep may result in poor psychological health.…”

Section: Introductionmentioning

confidence: 99%

Children with cerebral palsy: A cross‐sectional study of their sleep and their caregiver's sleep quality, psychological health and well‐being

Lang

Boucaut

Guppy

et al. 2021

Child

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Background Children with cerebral palsy (CP) are more likely to experience sleep problems. Their sleep difficulties have been shown to be related to poorer sleep quality for their parents and caregivers. While poor sleep has been linked with poorer psychological health in other populations, few studies have focused on the potential effects of children's and caregivers' sleep disturbance on caregivers' psychological health and well‐being in families of children with CP. This study investigated the association between caregivers' psychological health and well‐being and their sleep quality and the sleep of their children with CP. Method Ninety‐four caregivers (86% mothers; age range = 29–76 years) of children with CP aged 4 to 14 years of varying physical abilities (Gross Motor Function Classification Scale expanded and revised—level I (24), II (20), III (16), IV (10), V (24)) were recruited from a state‐wide rehabilitation service. Caregivers completed the Depression, Anxiety and Stress Scale‐21, Warwick‐Edinburgh Mental Wellbeing Scale, Resilience Scale, Pediatric Sleep Questionnaire, Pittsburgh Sleep Quality Index, and a demographic questionnaire. Results Sleep problems were reported for 55% of children. Poor sleep quality was reported by 71% of caregivers. While 25% of caregivers reported positive well‐being and 86% reported high to very high levels of resilience, 44% reported poor psychological health. Child sleep problems were related to poorer caregiver sleep quality (r = 0.47, p < 0.001). Poorer caregiver sleep quality was related to poorer caregiver psychological health (r = 0.43–0.51, all p < 0.001) and well‐being (r = −0.48, p < 0.001), but not resilience (r = 0.18, p = 0.11). Conclusions High numbers of children with CP and their caregivers experience poor sleep that extends far past infancy. Poor sleep quality is associated with poorer psychological health and well‐being for caregivers. Further development of responsive support services that address caregivers' sleep is essential.

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“…Sleep has important implications for every aspect of a caregiver's life, although it often has received little attention. 8 Previous research has linked poor sleep or disrupted sleep in healthy adults with elevated blood pressure, poor cardiovascular outcomes, impaired memory, and increased reports of stroke, cancer, fatigue, and higher risk of obesity. [9][10][11] While there are few studies examining sleep in caregivers of children with chronic illness, and even less in caregivers of children with T1D, researchers have found that poor sleep is a concern.…”

Section: Resultsmentioning

confidence: 99%

Sleep in Caregivers of Children With Type 1 Diabetes

et al. 2018

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Sleep Outcomes for Parents of Children With Neurodevelopmental Disabilities: A Systematic Review

Cited by 20 publications

References 84 publications

Potential Role of Neuroactive Tryptophan Metabolites in Central Fatigue: Establishment of the Fatigue Circuit

Potential Role of Neuroactive Tryptophan Metabolites in Central Fatigue: Establishment of the Fatigue Circuit

Children with cerebral palsy: A cross‐sectional study of their sleep and their caregiver's sleep quality, psychological health and well‐being

Sleep in Caregivers of Children With Type 1 Diabetes

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