Sleep Polygraphic Studies on Infantile Spasms

Hashimoto, Toshiaki; Ohara, Katsuaki; Hiura, Kenji; Suzue, Junji; Kawano, Nobour; Kobayashi, Yoshiko; Kokawa, Tamio; Fukuda, Kuniaki; Endo, Shoichi; Miyao, Masaru

doi:10.1111/j.1442-200x.1978.tb00143.x

Cited by 6 publications

(3 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Satoh et al (11), using autopsy specimens, reported that IS were frequently associated with brainstem involvement, including hypogenesis of the tegmentum, a spongiform area around the central tegmental tract and localized periaqueductal glia scars. Hashimoto et al (4) and Hrachovy et al (6) reported that IS were consistently associated with altered sleep patterns as indicated by suppression of total sleep time, marked reduction of rapideye-movement (REM) sleep and decreased REMs during stage REM sleep. These results suggest that the basic dysfunction in IS occurs primarily at the pontine level.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Brainstem Involvement in Infantile Spasms: A Study Employing Brainstem Evoked Potentials and Magnetic Resonance Imaging

et al. 1993

View full text Add to dashboard Cite

Ten patients with infantile spasms underwent brainstem evoked potentials and magnetic resonance imaging (MRI) examination to evaluate brainstem involvement. Short latency somatosensory evoked potentials and auditory brainstem responses were abnormal in seven and five of the 10 patients, respectively. MRI findings were abnormal in nine of the 10 patients. Six patients demonstrated various degrees of atrophy of the brainstem. In all of these cases brainstem evoked potentials were abnormal. This study demonstrates that infantile spasms are frequently associated with brainstem dysfunction and raises the hypothesis that brain atrophy involving the brainstem might be a cause of infantile spasms. In addition, this study also documents the combination of brainstem evoked potentials and MRI examination is valuable tool in the evaluation of brainstem involvement in infantile spasms.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Infantile spasms (IS) are an age-dependent epileptic encephalopathy that arise from various etiologies. Many previous reports (2,4,6,11,12) have attempted to clarify the pathologic lesions present in IS, however, no consensus has emerged.…”

Section: Introductionmentioning

confidence: 99%

Brainstem Involvement in Infantile Spasms: A Study Employing Brainstem Evoked Potentials and Magnetic Resonance Imaging

et al. 1993

View full text Add to dashboard Cite

show abstract

“…Many studies (10,12,17,18,20,24) have attempted. to clarify the pathologie lesions producing infantile spasms, but no consensus has yet emerged.…”

Section: Discussionmentioning

confidence: 99%

Infantile Spasms with Predominantly Unilateral Cerebral Abnormalities

Miyazaki

Hashimoto²,

Omura³

et al. 1994

Neuropediatrics

View full text Add to dashboard Cite

To investigate the pathogenesis of infantile spasms, 12 children underwent a combination of neurophysiologic and neuroimaging studies including brainstem evoked potentials and single photon emission computed tomography with 99mTcHMPAO. Three of the children had localized cerebral abnormalities on neuroimaging, i.e. right frontotemporal cortical microdysgenesis, left frontotemporal polymicrogyria, and right parietooccipitotemporal porencephalic cyst. Neurophysiologic studies also indicated that a single cerebral hemisphere was predominantly involved, while the other hemisphere and the brainstem were relatively spared, a result compatible with the clinical findings of hemiparesis and hemiconvulsion. In these three patients, administration of carbamazepine was followed by marked improvement of the clinical and electroencephalographic findings. Our results suggest that a combination of noninvasive examinations can distinguish a particular subtype of infantile spasms associated with a localized cerebral abnormality and responsive to carbamazepine.

show abstract

Polysomnographical assessment of the pathophysiology of West syndrome

Kohyama

2001

Brain and Development

View full text Add to dashboard Cite

Sleep Polygraphic Studies on Infantile Spasms

Cited by 6 publications

References 9 publications

Brainstem Involvement in Infantile Spasms: A Study Employing Brainstem Evoked Potentials and Magnetic Resonance Imaging

Brainstem Involvement in Infantile Spasms: A Study Employing Brainstem Evoked Potentials and Magnetic Resonance Imaging

Infantile Spasms with Predominantly Unilateral Cerebral Abnormalities

Polysomnographical assessment of the pathophysiology of West syndrome

Contact Info

Product

Resources

About