Sleep Problems in Children With Prenatal Substance Exposure

Stone, Kristen C.; LaGasse, Linda L.; Lester, Barry M.; Shankaran, Seetha; Bada, Henrietta S.; Bauer, Charles R.; Hammond, Jane

doi:10.1001/archpediatrics.2010.52

Cited by 31 publications

(26 citation statements)

References 31 publications

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“…This is supported by our failure to find an independent association between paternal circadian preference and sleep functioning in early childhood. Some prenatal factors, such as mood disturbances [37] and/or substance exposure [38] have been reported to associate with sleep quality in the offspring. Moreover, we recently reported that symptoms of mood disturbances, ADHD and stress in mothers during pregnancy were associated with certain sleep difficulties and sleep practices at the age of three months [28].…”

Section: Discussionmentioning

confidence: 99%

The role of parental circadian preference in the onset of sleep difficulties in early childhood

et al. 2019

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Background: Chronotype is a construct contributing to individual differences in sleep-wake timing. Previous studies with children have found that evening-types exhibit greater sleep difficulties. Infant sleep quality can be modulated by several factors, such as parental characteristics. We examined the association between parental circadian preference and sleep in early childhood. Methods: This study was based on a longitudinal birth cohort, with several measurement points. We used information regarding parental questionnaires during pregnancy and children's sleep measures at three, eight, 18 and 24 months. In total, 1220 mothers, 1116 fathers, 993 infants at three months, 990 infants at eight months, 958 children at 18 months, and 777 children at 24 months were analyzed. Parental circadian preference was measured using the Horne-€ Ostberg Morningness-Eveningness Questionnaire. Concerning children's sleep, we used the Brief Infant Sleep Questionnaire (BISQ) and the Infant Sleep Questionnaire (ISQ) at each time point. Results: Maternal circadian preference was associated with infants' circadian rhythm development at three, eight, 18 and 24 months. Furthermore, increased maternal eveningness was also related to short sleep during daytime at three months, and nighttime at three and eight months, to long sleep-onset latency at three, 18 and 24 months, to late bedtime at three, eight and 18 months, and to sleep difficulties at eight and 24 months. Paternal circadian preference was not associated with any sleep variable at any time point. Conclusion: Maternal circadian preference is related to several sleep difficulties in early childhood, and it may be considered a potential risk factor for the onset of early sleeping problems.

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Section: Discussionmentioning

confidence: 99%

The role of parental circadian preference in the onset of sleep difficulties in early childhood

et al. 2019

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“…18 There is evidence that prenatal substance exposure could influence children's sleep problems during the first 12 years of life. 19 Other environmental exposures (eg, arsenic, mixed metals, "dioxin" 2,3,7,8-tetrachlorodibenzo-p-dioxin, pesticides, drinking water nitrates, solvents) are known to be toxic to the cardiovascular system and warrant additional study.…”

Section: Biomarkers Of Environmental Exposure Throughout the Life Coursementioning

confidence: 99%

Promoting Cardiovascular Health in Early Childhood and Transitions in Childhood through Adolescence: A Workshop Report

Daniels

Pratt

Hollister

et al. 2019

The Journal of Pediatrics

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“…Indeed, poor sleep and disrupted circadian timing are associated with the development of metabolic and psychiatric disorders (23,30). Compared with cocaine, opioids, cannabis, and alcohol use, perinatal nicotine exposure has the strongest correlation with childhood sleep problems (40). However, it is unknown whether perinatal nicotine exposure causes altered sleep in adulthood and whether this is associated with other neuropsychiatric problems.…”

mentioning

confidence: 99%

Enduring effects of perinatal nicotine exposure on murine sleep in adulthood

Borniger

Don

Zhang

et al. 2017

American Journal of Physiology-Regulatory, Integrative and Comp

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The long-term consequences of early life nicotine exposure are poorly defined. Approximately 8-10% of women report smoking during pregnancy, and this may promote aberrant development in the offspring. To this end, we investigated potential enduring effects of perinatal nicotine exposure on murine sleep and affective behaviors in adulthood (~13-15 wk of age) in C57Bl6j mice. Mothers received a water bottle containing 200 µg/ml nicotine bitartrate dihydrate in 2% wt/vol saccharin or pH-matched 2% saccharin with 0.2% (vol/vol) tartaric acid throughout pregnancy and before weaning. Upon reaching adulthood, offspring were tested in the open field and elevated plus maze, as well as the forced swim and sucrose anhedonia tests. Nicotine-exposed male (but not female) mice had reduced mobility in the open field, but no differences were observed in anxiety-like or depressive-like responses. Upon observing this male-specific phenotype, we further assessed sleep-wake states via wireless EEG/EMG telemetry. Following baseline recording, we assessed whether mice exposed to nicotine altered their homeostatic response to 5 h of total sleep deprivation and whether nicotine influenced responses to a powerful somnogen [i.e., lipopolysaccharides (LPS)]. Males exposed to perinatal nicotine decreased the percent time spent awake and increased time in non-rapid eye movement (NREM) sleep, without changes to REM sleep. Nicotine-exposed males also displayed exaggerated responses (increased time asleep and NREM spectral power) to sleep deprivation. Nicotine-exposed animals additionally had blunted EEG slow-wave responses to LPS administration. Together, our data suggest that perinatal nicotine exposure has long-lasting effects on normal sleep and homeostatic sleep processes into adulthood.

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Sleep Problems in Children With Prenatal Substance Exposure

Cited by 31 publications

References 31 publications

The role of parental circadian preference in the onset of sleep difficulties in early childhood

The role of parental circadian preference in the onset of sleep difficulties in early childhood

Promoting Cardiovascular Health in Early Childhood and Transitions in Childhood through Adolescence: A Workshop Report

Enduring effects of perinatal nicotine exposure on murine sleep in adulthood

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