Sleep quality and OPRM1 polymorphisms: a cross-sectional study among opioid-naive individuals

Zahari, Zalina; Ibrahim, Muslih Abdulkarim; Musa, Nurfadhlina; Tan, Soo Choon; Mohamad, Nasir; Ismail, Rusli

doi:10.1590/s2175-97902018000117217

Cited by 4 publications

(1 citation statement)

References 42 publications

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“…Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI)-Malay. [ 46 47 ] The PSQI-M contains 19 items that are included in scoring. The 19 individual items were used to generate seven component scores: subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, use of sleep medications, and daytime dysfunction.…”

Section: Aterials and M Ethodsmentioning

confidence: 99%

Influence of DRD2 polymorphisms on the clinical outcomes of opioiddependent patients on methadone maintenance therapy

et al. 2020

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A BSTRACT Introduction: Dopamine receptor D2 (DRD2) is one of the dopamine receptors that have been studied in relation to opioid dependence. It is possible, therefore, that DRD2 gene ( DRD2 ) polymorphisms influence treatment outcomes of patients with opioid dependence. The objective of this study was to investigate the influence of DRD2 polymorphisms on the clinical outcomes of opioid-dependent patients on methadone maintenance therapy (MMT). Materials and Methods: Patients with opioid dependence ( n = 148) were recruited from MMT clinics. Pain sensitivity, severity of the opiate withdrawal syndrome, and sleep quality were assessed using cold pressor test (CPT), Subjective Opiate Withdrawal Scale (SOWS-M), and Pittsburgh Sleep Quality Index (PSQI)-Malay, respectively. Deoxyribonucleic acid (DNA) was extracted from whole blood, and then was used for genotyping of Val96Ala, Leu141Leu, Val154Ile, Pro310Ser, Ser311Cys, TaqI A, -141C Ins/Del , and A -241 G polymorphisms. Results: Among 148 patients, 8.1% ( n = 12), 60.8% ( n = 90), 27.7% ( n = 41), and 29.1% ( n = 43) had at least one risk allele for Ser311Cys, TaqI A, -141C Ins/Del, and A-241G polymorphisms, respectively. There were no significant differences in pain responses (pain threshold, tolerance, and intensity), SOWS, and PSQI scores between DRD2 polymorphisms. Conclusion: The common DRD2 polymorphisms are not associated with pain sensitivity, severity of the opiate withdrawal syndrome, and sleep quality in patients with opioid dependence on MMT. However, this may be unique for Malays. Additional research should focus on investigating these findings in larger samples and different ethnicity.

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Section: Aterials and M Ethodsmentioning

confidence: 99%

Influence of DRD2 polymorphisms on the clinical outcomes of opioiddependent patients on methadone maintenance therapy

et al. 2020

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Clinical Phenotypes Supporting the Relationship Between Sleep Disturbance and Impairment of Placebo Effects

Wang,

Varghese,

Muhammed

et al. 2024

The Journal of Pain

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High Frequency of the Opioid Receptor µ-1 (OPRM1) A118G Polymorphism, an Opioid Drug Therapy Related Gene, in the Indonesian Population

Alvina

Ikawati

Swasthikawati³

et al. 2020

CPPM

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Background: The opioid receptor μ-1 (OPRM1) has become one of the most studied genes in pharmacogenetics, as this gene encodes the μ-opioid receptor (MOR), which plays a role in opioid drugs response, as well as in various disorders. One of its variants, A118G, which is found at a high frequency in the Asian population, has been associated with loss of sensitivity to and an increased requirement for analgesics in the treatment of pain, increased pain sensitivity, various types of substance dependencies, and the development of breast cancer. However, there are still limited reports about this gene polymorphism in the Indonesian population. Objective: The study aimed to determine the allele frequencies of the OPRM1 A118G polymorphism among the Indonesian population. Method: A cross-sectional study of 158 subjects, comprising 79 males and 79 females, was conducted among Indonesians, and genotype analysis was carried out by a modified allele-specific Polymerase Chain Reaction (PCR) method. Results: A frequency of 60.4% was found for the G allele among Indonesian samples, with a higher frequency being present in males (66.5%). The A allele was found at frequencies of 33.5% and 45.6% in males and females, respectively. A significant difference in allele frequency was found between males and females (p = 0.029, OR = 1.659, 95% CI [1.052–2.614]), while there was no significant difference in genotype frequencies between groups. Conclusion: A high prevalence of the OPRM1 A118G polymorphism was found in the Indonesian population, with the G allele frequency tending to be higher in males.

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Sleep quality and OPRM1 polymorphisms: a cross-sectional study among opioid-naive individuals

Cited by 4 publications

References 42 publications

Influence of DRD2 polymorphisms on the clinical outcomes of opioiddependent patients on methadone maintenance therapy

Influence of DRD2 polymorphisms on the clinical outcomes of opioiddependent patients on methadone maintenance therapy

Clinical Phenotypes Supporting the Relationship Between Sleep Disturbance and Impairment of Placebo Effects

High Frequency of the Opioid Receptor µ-1 (OPRM1) A118G Polymorphism, an Opioid Drug Therapy Related Gene, in the Indonesian Population

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