Sleep-related movement disorders and disturbances of motor control

Bargiotas, Panagiotis; Bassetti, C.

doi:10.1097/wco.0000000000000466

Cited by 12 publications

(3 citation statements)

References 123 publications

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“…Our study did not attempt to explore the mechanisms underlying our findings, which may concern the different pattern of neuropathology in multiple system atrophy versus Parkinson's disease. Neurodegeneration may cause an imbalance between inhibitory and excitatory mechanisms of motor control during sleep (Bargiotas & Bassetti, 2017). The pathophysiology of RBD is thought to include degeneration of glutamatergic neurons in the sublaterodorsal nucleus (SLD) of the pontine tegmentum, which indirectly inhibit motoneurons during REM sleep acting through synaptic relays in the medulla and/or the spinal cord (Arrigoni et al, 2016; Lu et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Pervasive and diffuse muscle activity during REM sleep and non‐REM sleep characterises multiple system atrophy in comparison with Parkinson's disease

Silvani

Baldelli

Giannini

et al. 2022

Journal of Sleep Research

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Summary Multiple system atrophy (MSA) and Parkinson's disease (PD) may share overlapping features particularly at early disease stage, including sleep alterations, but have profoundly different prognoses. Certain sleep phenomena and disorders of motor control are more prevalent in multiple system atrophy, such as REM sleep behaviour disorder (RBD). We quantitatively tested whether pervasive muscle activity during sleep occurs in subjects with multiple system atrophy versus Parkinson's disease. Laboratory polysomnographic studies were performed in 50 consecutive subjects with Parkinson's disease and 26 age‐ and gender‐matched subjects with multiple system atrophy at <5 years from disease onset. The distributions of normalised electromyographic activity of submentalis, wrist extensor, and tibialis anterior muscles in different wake–sleep states during the night were analysed. Subjects with multiple system atrophy had significantly higher activity of submentalis, wrist extensor, and tibialis anterior muscles than subjects with Parkinson's disease during non‐REM sleep, including separately in stages N1, N2, and N3, and during REM sleep, but not during nocturnal wakefulness. The activity of wrist extensor and tibialis anterior muscles during non‐REM sleep and the activity of tibialis anterior muscles during REM sleep were also significantly higher in subjects with multiple system atrophy and RBD than in subjects with Parkinson's disease and RBD. In conclusion, with respect to Parkinson's disease, multiple system atrophy is characterised by a pervasive and diffuse muscle overactivity that involves axial and limb muscles and occurs not only during REM sleep, but also during non‐REM sleep and between subjects with comorbid RBD.

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Section: Discussionmentioning

confidence: 99%

Pervasive and diffuse muscle activity during REM sleep and non‐REM sleep characterises multiple system atrophy in comparison with Parkinson's disease

Silvani

Baldelli

Giannini

et al. 2022

Journal of Sleep Research

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“…Thus, the engagement of overlapping neuronal populations for motor suppression and sleep generation appears to be a common theme along the neural control pathway. Such a circuit design can ensure a strong coupling between sleep and immobility at the behavioral level, and breakdown of the shared control mechanism may underlie a variety of sleep-related movement disorders (Bargiotas and Bassetti, 2017).…”

Section: Discussionmentioning

confidence: 99%

Sleep and Motor Control by a Basal Ganglia Circuit

Liu

Zheng

et al. 2018

Preprint

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From invertebrates to humans, a defining feature of sleep is behavioral immobility(Campbell and Tobler, 1984; Hendricks et al., 2000; Shaw et al., 2000). In mammals, diminished electromyographic (EMG) activity is a major criterion for both rapid eye movement (REM) and non-REM (NREM) sleep. However, the relationship between sleep and motor control at the neuronal level remains poorly understood. Here we show that regions of the basal ganglia long known to be essential for motor suppression also play a key role in sleep generation. Optogenetic or chemogenetic activation of GABAergic neurons in mouse substantia nigra pars reticulata (SNr) strongly increased both REM and NREM sleep, whereas their inactivation suppressed sleep and increased wakefulness. Analysis of natural home-cage behavior showed that mice transition sequentially through several behavioral states: locomotion, non-locomotor movement, quiet wakefulness, and sleep. Activation/inactivation of SNr neurons promoted/suppressed sleep by biasing the direction of progression through the natural behavioral sequence. Virus-mediated circuit tracing showed that SNr GABAergic neurons project to multiple wake-promoting monoaminergic cell groups in addition to the thalamus and mesencephalic locomotor region, and activating each projection promoted sleep. Within the thalamus, direct optogenetic inactivation of glutamatergic neurons is sufficient to enhance sleep, but the effect is largely restricted to the regions receiving SNr projection. Furthermore, a major source of excitatory inputs to the SNr is the subthalamic nucleus (STN), and activation of neurotensin-expressing glutamatergic neurons in the STN also promoted sleep. Together, these results demonstrate a key role of the STN-SNr basal ganglia pathway in sleep generation and reveal a novel circuit mechanism linking sleep and motor control.

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“…Due to the lack of prospective research on the coexistence of VP with sleep disorders such as insomnia, PLMS, and RLS, the most commonly applied therapy is the same as in the general population. Behavioral, psychological, and pharmaceutical treatments are available ( 5 ), but their duration of effectiveness is constrained. There is a high risk of rebound or other side effects.…”

Section: Introductionmentioning

confidence: 99%

Electro-acupuncture on Vascular Parkinsonism with multiple sleep disorders: A Case Report

YAN

Fan

et al. 2022

Front. Neurol.

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Vascular Parkinsonism (VP) is a kind of rare secondary Parkinsonism caused by vascular lesions. Patients with VP experience not only movement disorders but also sleep disorders. But treatment options are limited and often associated with undesirable adverse effects. Electro-acupuncture (EA) is a safe, rapid work, easy operation, and convenient complementary replacement therapy. We report a case of a 51-year-old man who presented with VP and multiple sleep disorders. Based on clinical evaluation and nocturnal hospital-based polysomnography (PSG), the patient had severe PLMD (PSG showed severe periodic leg movements), excessive daytime sleepiness (EDS, the score of the ESS is 16), and probable rapid eye movement sleep disorder (RBD). Parkinson's disease sleep scale (PDSS) score, Pittsburgh sleep quality index (PSQI), and periodic leg movements index were 93, 11, and 135.2, respectively. After 8 weeks of EA treatment, the patient reported that the symptoms of subjective and objective sleep disturbance were significantly alleviated without any discomfort. This case report may provide a new alternative and complementary therapy for VP patients with sleep disturbance but more definitive and robust evidence is needed to support its efficacy.

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Sleep-related movement disorders and disturbances of motor control

Cited by 12 publications

References 123 publications

Pervasive and diffuse muscle activity during REM sleep and non‐REM sleep characterises multiple system atrophy in comparison with Parkinson's disease

Pervasive and diffuse muscle activity during REM sleep and non‐REM sleep characterises multiple system atrophy in comparison with Parkinson's disease

Sleep and Motor Control by a Basal Ganglia Circuit

Electro-acupuncture on Vascular Parkinsonism with multiple sleep disorders: A Case Report

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