Sleep restriction leads to increased activation of brain regions sensitive to food stimuli

St‐Onge, Marie‐Pierre; McReynolds, Andrew; Trivedi, Zalak B; Roberts, Amy L.; Sy, Melissa; Hirsch, Joy

doi:10.3945/ajcn.111.027383

Cited by 238 publications

(158 citation statements)

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“…26 Further experimental work may settle the issue. 6,27,28 Limitations of our study include the cross-sectional design and the fact that we did not confirm patient reports of sleep problems with polysomnography or actigraphy. Our relatively small sample size and the fact that data were collected from one center also limit results.…”

Section: Discussionmentioning

confidence: 99%

“…25 St-Onge et al compared volunteers with 6 days of restricted sleep (4 h of sleep per night) or 6 days of habitual sleep (9 h of sleep per night) in a crossover design and report that functional MRI data indicated greater interest in food stimuli after sleep restriction. 6 Our study has several strengths. Based on comparisons with the target population, our sample is representative with respect to multiple characteristics.…”

Section: Discussionmentioning

confidence: 99%

“…25,6 For example, Wheaton et al model "the number of days in the past 30, when the respondent did not get enough rest or sleep." 25 This construct appears to be an amalgam of sleep quantity and quality and may account for the absence of a U-shaped relationship in their data.…”

Section: Discussionmentioning

confidence: 99%

“…[2][3][4] Since there are physiologic linkages between the "sleep system" and the "metabolic system," and a variety of supporting circumstantial data, investigators have hypothesized that inadequate sleep contributes to the obesity epidemic by increasing stress, appetite, and fatigue. 5,6 The hypothesized inadequate sleep-to-obesity pathway is distinct from the more familiar obesity-to-sleep apnea pathway. 7,8 Circumstantial data supporting the inadequate sleep-to-obesity hypothesis include information from laboratory, clinical, and population settings.…”

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confidence: 99%

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Sleep Duration, Quality, or Stability and Obesity in an Urban Family Medicine Center

Logue¹,

Scott²,

Palmieri

et al. 2014

Journal of Clinical Sleep Medicine

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Purpose: Inadequate sleep has negative metabolic consequences that may contribute to obesity. A priori hypotheses posit relationships between sleep characteristics, carbohydrate and lipid metabolism, appetite, fatigue, and obesity in laboratory, clinical, and population settings. There are few reports from primary care; and none that address sleep duration, quality, and stability. This study examines the relationship between three sleep characteristics-duration, quality, or stability-and obesity in our urban hospital affi liated family medicine center in Akron, Ohio. Methods: A systematic sampling process yielded 225 representative patients who completed the Pittsburgh Sleep Quality Index, the Berlin Apnea Questionnaire, and the Sleep Timing Questionnaire. Demographic, body mass, hypertension, and insurance data were obtained from the electronic medical record. Associations between selfreported sleep characteristics and obesity were examined via contingency tables and regression models. Results: Seventy-eight percent (78%) reported poor quality sleep, 59% had elevated Berlin apnea-risk scores, 12% reported restless legs symptoms, and 9% reported a prior diagnosis of sleep apnea; 62% were obese. We found signifi cant (p < 0.05) associations between sleep quality, duration or bedtime stability, and obesity. The association between sleep quality and obesity was negative and linear (69%, 72%, 56%, 43%), while the association between sleep duration and obesity was U-shaped (74%, 53%, 53%, 62%; linear term p = 0.02 and quadratic term p = 0.03). Less stable bedtimes during the week (OR = 2.3, p = 0.008) or on the weekend (OR = 1.8, p = 0.04) were also associated with obesity. The association between sleep quality and obesity was not explained by patient demographics or snoring (OR adj = 2.2; p = 0.008) Conclusion: This study adds to the sparse literature on the relationship between three self-reported sleep characteristics and obesity in urban primary care settings which typically differ from both general population and specialty outpatient settings. Keywords: Sleep quality, sleep duration, sleep timing, obesity, primary care Citation: Logue EE; Scott ED; Palmieri PA; Dudley P. Sleep duration, quality, or stability and obesity in an urban family medicine center.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Sleep Duration, Quality, or Stability and Obesity in an Urban Family Medicine Center

Logue¹,

Scott²,

Palmieri

et al. 2014

Journal of Clinical Sleep Medicine

View full text Add to dashboard Cite

show abstract

“…Evidence shows that changes in caloric intake, 3 brain activation 4 and biochemical processing 5 occur with less sleep. Collectively these studies suggest that sleep may have an integral role in the development and treatment of obesity.…”

Section: Summary Of the Problemmentioning

confidence: 99%

Should Primary Care Physicians Address Sleep to Improve Weight Loss in Obese Patients? A Clin-IQ

Knox¹

2015

Journal of Patient-Centered Research and Reviews

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Habitual Short Sleep Duration, Diet, and Development of Type 2 Diabetes in Adults

Nôga,

Meth,

Pacheco

et al. 2024

JAMA Netw Open

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ImportanceUnderstanding the interplay between sleep duration, dietary habits, and the risk of developing type 2 diabetes (T2D) is crucial for public health and diabetes prevention strategies.ObjectiveTo investigate the associations of type of diet and duration of sleep with the development of T2D.Design, Setting, and ParticipantsData derived from the UK Biobank baseline investigation (2006-2010) were analyzed for this cohort study between May 1 and September 30, 2023. The association between sleep duration and healthy dietary patterns with the risk of T2D was investigated during a median (IQR) follow-up of 12.5 (11.8-13.2) years (end of follow-up, September 30, 2021).ExposureFor the analysis, 247 867 participants were categorized into 4 sleep duration groups: normal (7-8 hours per day), mild short (6 hours per day), moderate short (5 hours per day), and extreme short (3-4 hours per day). Their dietary habits were evaluated based on population-specific consumption of red meat, processed meat, fruits, vegetables, and fish, resulting in a healthy diet score ranging from 0 (unhealthiest) to 5 (healthiest).Main Outcomes and MeasuresCox proportional hazards regression analysis was used to calculate hazard ratios (HRs) and 95% CIs for the development of T2D across various sleep duration groups and healthy diet scores.ResultsThe cohort comprised 247 867 participants with a mean [SD] age of 55.9 [8.1] years, of whom 52.3% were female. During the follow-up, 3.2% of participants were diagnosed with T2D based on hospital registry data. Cox regression analysis, adjusted for confounding variables, indicated a significant increase in the risk of T2D among participants with 5 hours or less of daily sleep. Individuals sleeping 5 hours per day exhibited a 1.16 adjusted HR (95% CI, 1.05-1.28), and individuals sleeping 3 to 4 hours per day exhibited a 1.41 adjusted HR (95% CI, 1.19-1.68) compared with individuals with normal sleep duration. Furthermore, individuals with the healthiest dietary patterns had a reduced risk of T2D (HR, 0.75 [95% CI, 0.63-0.88]). The association between short sleep duration and increased risk of T2D persisted even for individuals following a healthy diet, but there was no multiplicative interaction between sleep duration and healthy diet score.Conclusions and RelevanceIn this cohort study involving UK residents, habitual short sleep duration was associated with increased risk of developing T2D. This association persisted even among participants who maintained a healthy diet. To validate these findings, further longitudinal studies are needed, incorporating repeated measures of sleep (including objective assessments) and dietary habits.

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Sleep restriction leads to increased activation of brain regions sensitive to food stimuli

Abstract: The findings of this study link restricted sleep and susceptibility to food stimuli and are consistent with the notion that reduced sleep may lead to greater propensity to overeat.

Cited by 238 publications

References 42 publications

Sleep Duration, Quality, or Stability and Obesity in an Urban Family Medicine Center

Sleep Duration, Quality, or Stability and Obesity in an Urban Family Medicine Center

Should Primary Care Physicians Address Sleep to Improve Weight Loss in Obese Patients? A Clin-IQ

Habitual Short Sleep Duration, Diet, and Development of Type 2 Diabetes in Adults

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