Sleep Spindle Activity Changes in Patients With Affective Disorders

Maertelaer, Viviane De; Hoffman, Gloria E.; Lemaire, Mathieu; Mendlewicz, Julien

doi:10.1093/sleep/10.5.443

Cited by 73 publications

(44 citation statements)

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“…the absolute sleep spindle amplitudes divided by non-REM sleep duration). This seems in contrast to the decreased sleep spindle activity reported in earlier studies (de Maertelaer et al, 1987, Goetz et al, 1983 and no difference in such activity in the mixed gender group with low severity (Ferrarelli et al, 2007). Indeed, healthy women have been shown to display more sleep spindle activity than men (Huupponen et al, 2002), suggesting differential regulation by gender in sleep spindles and possibly differential effects in MDD as well.…”

Section: Sleep Spindles and Depressioncontrasting

confidence: 87%

“…Early sleep studies indicated decreases in sleep spindle activity in MDD patients (de Maertelaer et al, 1987, Goetz et al, 1983 confirmed also in high-risk groups (Lopez et al, 2010;Steiger et al, 2014) and those with manic-depression (DiazGuerroro et al, 1946). Moreover, a consistent lower amount of stage 2 NREM sleep was reported in MDD patients (Lauer et al, 1991;Mendlewicz and Kerkhofs, 1991) hinting to lower amount of sleep spindles as well.…”

Section: Sleep Spindles and Depressionmentioning

confidence: 92%

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Sleep spindles and cognition in depression

Bovy¹,

Dresler²,

Weber³

2017

Preprint

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Section: Sleep Spindles and Depressioncontrasting

confidence: 87%

Section: Sleep Spindles and Depressionmentioning

confidence: 92%

Sleep spindles and cognition in depression

Bovy¹,

Dresler²,

Weber³

2017

Preprint

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“…Alzheimer's disease [111], sporadic Creutzfeldt-Jakob disease [112], autism and Asperger's syndrome [113,114], and affective disorders [115]. In most of these cases, spindle reduction is just one of several sleep abnormalities associated with the pathology.…”

Section: Sleep Spindles In Pathologymentioning

confidence: 99%

Manipulating sleep spindles – expanding views on sleep, memory, and disease

Astori

Wimmer²,

Lüthi³

2013

Trends in Neurosciences

132

113

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Abstract:Sleep spindles are distinctive electroencephalographic (EEG) oscillations emerging during non-rapid-eye-movement sleep (NREMS) that have been implicated in multiple brain functions, including sleep quality, sensory gating, learning and memory. Despite considerable knowledge about the mechanisms underlying these neuronal rhythms, their function remains poorly understood and current views are largely based on correlational evidence. Here, we review recent studies in humans and rodents that have begun to broaden our understanding of the role of spindles in the normal and disordered brain. We show that newly identified molecular substrates of spindle oscillations, in combination with evolving technological progress, offer novel targets and tools to selectively manipulate spindles and dissect their role in sleep-dependent processes. Powered by Editorial Manager® and ProduXion Manager® from Aries Systems CorporationAstori et al. Highlights Newly recognized ion channel subtypes generating spindle rhythms are described. The contribution of spindles to arousal threshold and sleep quality is discussed. The proposed role of spindles in memory consolidation is examined. A function of thalamic spindles in neural development is suggested. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 4 Previous excellent reviews have thoroughly described cellular and network bases of spindle generation [3,6,7]. Here, we first review recent work on genetic models that has expanded the mechanistic understanding of this EEG rhythm through the modification of novel molecular substrates. We then discuss the current views about the functional aspects of spindles in brain physiology and pathology, as obtained from studies in naturally sleeping animals and humans. We highlight studies indicating that spindles are accessible for selective interventions, and that, with emerging technologies, will open avenues to decipher spindle function. Novel molecular aspects of spindle generationSleep spindles emerge from a limited set of cellular participants: the resonating core of these waxing-and-waning oscillations resides in the nRt-TC loop, which sustains repetitive burst discharges of its cellular components under the control of cortical inputs (Figure 1 Another important factor in the generation and maintenance of reticular intrinsic oscillations is the aforementioned SK2 or Kcnn2 channel. The vigorous Ca 2+ influx in nRt dendrites originating from Ca V 3.3 channels gates SK2 channels, thereby creating a burstafterhyperpolarization (bAHP) [12,19]. As T channels recover partially from inactivation duri...

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“…In depression, spindle density is decreased in adult patients (de Maertelaer et al 1987) and increased in adolescent patients (Goetz et al 1983). Generalized epilepsy is accompanied by a decrease in spindle occurrence compared to partial seizures and complex partial seizures (Drake et al 1991).…”

Section: Discussionmentioning

confidence: 99%

Mg 2+ reduces ACTH secretion and enhances spindle power without changing delta power during sleep in men - possible therapeutic implications

Murck¹,

Steiger²

1998

Psychopharmacology

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Disturbances of Mg2+ metabolism have been reported in association with affective disorders, seizures in eclampsia, and alcohol withdrawal. Mg2+ has been reported to have N-methyl-D-aspartate (NMDA)-antagonistic and gamma-aminobutyric acid (GABA)-agonistic properties and modulation of GABA(A)- and NMDA-dependent systems is involved in pharmacological treatment of affective disorders and seizures. We studied the effect of Mg2+ on sleep electroencephalogram (EEG) and nocturnal hormonal secretion in men. Ten normal controls were given MgSO4 (3 g MgSO4 between 2030 hours and 2100 hours, followed by 0.5 g MgSO4 per hour until 0700 hours) or placebo i.v. according to a randomized schedule. The sleep EEG was recorded from 2300 hours to 0700 hours. Blood samples were taken from 2000 hours to 0700 hours for analysis of plasma corticotropin (ACTH), cortisol, growth hormone, prolactin and melatonin. The sleep-EEG power within the spindle frequency range (11.0-12.9 Hz) showed a significant increase in the third sleep cycle, but delta power was unchanged throughout the night. ACTH concentration was suppressed between 2200 hours and 0700 hours. No changes in cortisol, growth hormone prolactin or melatonin release were found. The findings are consistent with the assumption that Mg2+ has GABA(A)-agonistic or NMDA-antagonistic effects on sleep and nocturnal hormonal secretion and hence may be useful in controlling depressive symptoms and seizures.

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Sleep Spindle Activity Changes in Patients With Affective Disorders

Cited by 73 publications

References 0 publications

Sleep spindles and cognition in depression

Sleep spindles and cognition in depression

Manipulating sleep spindles – expanding views on sleep, memory, and disease

Mg 2+ reduces ACTH secretion and enhances spindle power without changing delta power during sleep in men - possible therapeutic implications

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