Sleep structure in positive and negative schizophrenia

Rotenberg, Vadim S.; Indursky, P.; Hadjez, Jack; Martin, T.; Barak, Yoram; Gutman, Y.; Bichucher, A.

doi:10.1016/s0006-3223(97)87164-8

Cited by 4 publications

(3 citation statements)

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“…Another sleep EEG study found that positive symptom scores partially explained the variation (63%) in high frequency EEG activity during REM sleep ( Tekell et al, 2005 ). An association between increased positive psychotic symptoms and reduced REM density has also been reported ( Rotenberg et al, 1997 , Yang and Winkelman, 2006 ).…”

Section: Resultsmentioning

confidence: 81%

The role of sleep dysfunction in the occurrence of delusions and hallucinations: A systematic review

Reeve

Sheaves

Freeman

2015

Clinical Psychology Review

206

149

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BackgroundSleep dysfunction is extremely common in patients with schizophrenia. Recent research indicates that sleep dysfunction may contribute to psychotic experiences such as delusions and hallucinations.ObjectivesThe review aims to evaluate the evidence for a relationship between sleep dysfunction and individual psychotic experiences, make links between the theoretical understanding of each, and highlight areas for future research.MethodA systematic search was conducted to identify studies investigating sleep and psychotic experiences across clinical and non-clinical populations.Results66 papers were identified. This literature robustly supports the co-occurrence of sleep dysfunction and psychotic experiences, particularly insomnia with paranoia. Sleep dysfunction predicting subsequent psychotic experiences receives support from epidemiological surveys, research on the transition to psychosis, and relapse studies. There is also evidence that reducing sleep elicits psychotic experiences in non-clinical individuals, and that improving sleep in individuals with psychosis may lessen psychotic experiences. Anxiety and depression consistently arise as (partial) mediators of the sleep and psychosis relationship.ConclusionStudies are needed that: determine the types of sleep dysfunction linked to individual psychotic experiences; establish a causal connection between sleep and psychotic experiences; and assess treatments for sleep dysfunction in patients with non-affective psychotic disorders such as schizophrenia.

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Section: Resultsmentioning

confidence: 81%

The role of sleep dysfunction in the occurrence of delusions and hallucinations: A systematic review

Reeve

Sheaves

Freeman

2015

Clinical Psychology Review

206

149

View full text Add to dashboard Cite

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“…It means that REM sleep pressure and REM sleep requirement are decreased. EM density in the 1st and 3rd cycles is significantly lower in schizophrenic patients with the relative increase of positive symptoms in comparison to patients with the domination of negative symptoms (Rotenberg et al, 1997c). On the other hand, neuroleptic treatment leads to an increase in REM sleep.…”

Section: Psychosis and Search Activitymentioning

confidence: 80%

Search Activity Concept: Relationship between Behavior, Health and Brain Functions

Rotenberg

2009

Act Nerv Super

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Search activity concept provides a new classification of the behavior which distinguishes search activity (activity in the uncertain situation with the constant feedback between behavior and its outcome), stereotyped behavior with a definite probability forecast, panic (activity without feedback between activity and its outcome) and renunciation of search. Only search activity which includes fight, flight, orienting behavior and creativity raises the body's resistance to stress, to natural and experimentally induced pathology whereas renunciation of search which display itself in freezing, helplessness and depression forms a nonspecific predisposition to somatic disturbances (e.g. psychosomatic diseases). Dreams in REM sleep are regarded as a specific form of search activity aimed at compensating for the lack of search in waking. REM sleep deprivation on a small as well as on rotating platform raises the requirement in REM sleep by frustrating search activity. It is suggested that in wakefulness characterized by the prominent search activity the inhibitory alpha-2-adrenoreceptors became less sensitive to stimulation and consequently in this state the activity of the brain monoamine neurons is less limited by the level of brain monoamines. During renunciation of search brain monoamine synthesis is not stimulated by monoamine exhaustion. In REM sleep the critical level of brain monoamines for search activity to start is lower than in wakefulness and alpha-2-adrenoreceptors are less sensitive than in the state of renunciation of search although more sensitive than during search behavior in waking. REM sleep indirectly contributes to memory consolidation by carrying out its main function -restoration of search activity. A functionally sufficient REM sleep contains search activity in dreams (subject is active in his/her own dream scenario) while in functionally insufficient REM sleep dreams are characterized by subject's passive position and feeling of helplessness. REM sleep insufficiency is an obligate condition for mental and somatic disorders to appear. The difference between normal (adaptive) and pathological (maladaptive) emotional tension is determined by the presence or absence of search activity in the structure of emotional tension. Repression of the unacceptable motive causing neurotic anxiety is a human variant of renunciation of search. Hypochondriac symptoms are in negative relationships with psychosomatic disorders and they, as well as positive symptoms in schizophrenia and anorectic behavior in anorexia nervosa, represent a pathological misdirected search activity.

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“…Overall illness severity, as assessed by the BPRS or PANSS, has generally been associated with altered REM sleep, such as increased REM percentage, shorter REM latency, and decreased REM density (i.e.,(79, 84, 98, 99)). Greater positive symptom severity is typically associated with lower REM density or shortened REM latency in medicated, unmedicated and drug-naïve patients (79, 84, 88, 98–100). REM density was also found to correlate specifically with hallucinatory behavior, as assessed by the BPRS (87).…”

Section: Schizophrenia and Psychotic Disordersmentioning

confidence: 99%

Insomnia Comorbid to Severe Psychiatric Illness

Soehner

Kaplan

Harvey

2013

Sleep Medicine Clinics

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In psychiatric illness, there is a growing body of evidence indicating that sleep disturbances exert a detrimental influence on the course of these disorders and contribute to impaired function. Even when psychiatric disorders are successfully treated or stabilized, insomnia and other sleep disturbances often fail to remit. The present review focuses on sleep in two severe mental illnesses, namely bipolar disorder and schizophrenia. This article discusses the role of sleep disturbances and altered sleep architecture in relation to symptom status, functional impairment, quality of life, and the course of these disorders. Current evidence regarding pharmacological and psychological treatment approaches for insomnia in these populations is presented. This review also notes considerations for adapting Cognitive Behavioral Therapy for insomnia (CBT-I) procedures for severe mental illness and proposes directions for future research.

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Sleep structure in positive and negative schizophrenia

Cited by 4 publications

References 0 publications

The role of sleep dysfunction in the occurrence of delusions and hallucinations: A systematic review

The role of sleep dysfunction in the occurrence of delusions and hallucinations: A systematic review

Search Activity Concept: Relationship between Behavior, Health and Brain Functions

Insomnia Comorbid to Severe Psychiatric Illness

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