Sleep/wake cycles in the dark: sleep recorded by polysomnography in 26 totally blind subjects compared to controls

Léger, Damien; Guilleminault, Christian; Santos, Carmen Rodríguez; Paillard, Michel

doi:10.1016/s1388-2457(02)00221-3

Cited by 45 publications

(36 citation statements)

References 32 publications

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“…16,33 Furthermore, the dysregulated circadian rhythm negatively affects their ability to sleep and to maintain daytime vigilance. 14,16,21,32 In the present study, sleep-related problems such as nonrestorative sleep and excessive daytime sleepiness were found to be associated with lower mental and physical QOL in visually impaired individuals with LP and the controls. Several The data were controlled for gender, age at the onset of visual impairment, morbidity length of visual impairment, employment status, residential status, alcohol use, smoking habits and total walking time per day.…”

Section: Discussionsupporting

confidence: 49%

“…[7][8][9][10] Sleep-related problems have been observed frequently in visually impaired individuals. [11][12][13][14][15] Reportedly, especially in people without light perception (LP), inhibited transmission of light signals to the suprachiasmatic nuclei might cause sleeprelated problems because of external desynchronization of the biological clock. 16,17 Indeed, the rate of circadian-related sleepwake disorders is likely to be higher among visually impaired individuals without LP than among those with LP.…”

Section: Introductionmentioning

confidence: 99%

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A Nationwide Cross-Sectional Survey of Sleep-Related Problems in Japanese Visually Impaired Patients: Prevalence and Association with Health-Related Quality of Life

Tamura

Sasai-Sakuma

Morita

et al. 2016

Journal of Clinical Sleep Medicine

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Study Objectives: This questionnaire-based cross-sectional study was conducted (1) to estimate the prevalence of sleep-related problems, and (2) to explore factors associated with lower physical/mental quality of life (QOL), particularly addressing sleep-related problems among Japanese visually impaired people. Methods: This nationwide questionnaire-based survey was administered to visually impaired individuals through the Japan Federation of the Blind. Visually impaired individuals without light perception (LP) (n = 311), those with LP (n = 287), and age-matched and gender-matched controls (n = 615) were eligible for this study. Study questionnaires elicited demographic information, and information about visual impairment status, sleep-related problems, and health-related quality of life. Results: Visually impaired individuals with and without LP showed higher prevalence rates of irregular sleep-wake patterns and difficulty maintaining sleep than controls (34.7% and 29.4% vs. 15.8%, 60.1% and 46.7% vs. 26.8%, respectively; p < 0.001). These sleep-related problems were observed more frequently in visually impaired individuals without LP than in those with LP. Non-restorative sleep or excessive daytime sleepiness was associated with lower mental/physical QOL in visually impaired individuals with LP and in control subjects. However, visually impaired individuals without LP showed irregular sleepwake pattern or difficulty waking up at the desired time, which was associated with lower mental/physical QOL. Conclusions: Sleep-related problems were observed more frequently in visually impaired individuals than in controls. Moreover, the rates of difficulties were higher among subjects without LP. Sleep-related problems, especially circadian rhythm-related ones, can be associated with lower mental/physical QOL in visually impaired individuals without LP. Keywords: circadian rhythm sleep-wake disorder, health-related quality of life, light perception, prevalence, sleep-related problems, visual impairment I NTRO DUCTI O NVisually impaired individuals are likely to have any of several comorbid mental/physical disorders including diabetes mellitus, hypertension, cognitive impairment, and depression/ anxiety. [1][2][3][4][5][6] The severity of these mental/physical disorders is reportedly correlated with visual impairment.1-9 Therefore, those individuals might be at risk for lower health-related quality of life (QOL). 7-10Sleep-related problems have been observed frequently in visually impaired individuals.11-15 Reportedly, especially in people without light perception (LP), inhibited transmission of light signals to the suprachiasmatic nuclei might cause sleeprelated problems because of external desynchronization of the biological clock. 16,17 Indeed, the rate of circadian-related sleepwake disorders is likely to be higher among visually impaired individuals without LP than among those with LP.12 In Japan, no large nationwide study of this subject has ever been reported. The actual prevalence of sleep-related problems amon...

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Section: Discussionsupporting

confidence: 49%

Section: Introductionmentioning

confidence: 99%

A Nationwide Cross-Sectional Survey of Sleep-Related Problems in Japanese Visually Impaired Patients: Prevalence and Association with Health-Related Quality of Life

Tamura

Sasai-Sakuma

Morita

et al. 2016

Journal of Clinical Sleep Medicine

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“…Underexposure to natural bright light may disturb sleeping and waking patterns of humans, particularly for blind subjects [9]. In a previous study, we interviewed 1073 blind subjects with the help of Braille questionnaires and we found that blind subjects had significantly more insomnia and free running sleep-wake patterns than seeing controls [10,11].…”

Section: Introductionmentioning

confidence: 85%

Underexposure to light at work and its association to insomnia and sleepiness

Léger

Bayon

Elbaz

et al. 2011

Journal of Psychosomatic Research

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“…Insufficient bright light during the day thus might cause desynchronization of the sleep-awake cycle, inducing sleep problems. In fact, blind subjects showed significantly higher occurrences of insomnia than controls 4,5) . A recent study 6) reported a high frequency of insomnia and daytime somnolence in subjects who worked underground (metro and trains) compared with those working overground (buses and trams).…”

mentioning

confidence: 86%

Effect of Reduced Illumination on Insomnia in Office Workers

Kozaki

Miura

Takahashi

et al. 2012

Journal of Occupational Health

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Effect of Reduced Illumination on Insomnia in Office Workers: Tomoaki KOZAKI, et al. Faculty of Design, Kyushu University— Objective We evaluated the possible effects of reduced illumination in the workplace on insomnia among office workers. Methods Seventy‐two office workers answered the Athens Insomnia Scale (AIS) in July 2009 (under ordinary illumination, OI conditions) and July 2010 (under reduced illumination, RI conditions). The workers were divided into three groups, indoor workers (IWs), semioutdoor workers (SWs) and outdoor workers (OWs), according to the frequency of working outside of the office because a worker with a high frequency of working outside of the office might rarely be exposed to the lighting condition within an office. The first five items of the AIS (AIS‐5) were used to assess sleep difficulties, and the last three items (AIS‐3) assessed next‐day consequences of sleep or daytime symptoms, which often result from insomnia and/or sleep disorders. Results Illuminance levels at a height of 1,100 mm from the floor under the RI conditions (550–490 lux) were significantly lower than under the OI conditions (750–700 lux). The AIS‐5 score of the IWs was significantly increased under the RI conditions compared with the OI conditions. There was no difference in AIS‐3 scores between conditions for any group. Conclusion Indoor workers hardly went outside of the office and were exposed only to office light during the daytime. Thus, the underexposure to light could have had an impact on insomnia in those individuals. A novel lighting environment is required to optimize work‐related levels of light exposure.

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Sleep/wake cycles in the dark: sleep recorded by polysomnography in 26 totally blind subjects compared to controls

Cited by 45 publications

References 32 publications

A Nationwide Cross-Sectional Survey of Sleep-Related Problems in Japanese Visually Impaired Patients: Prevalence and Association with Health-Related Quality of Life

A Nationwide Cross-Sectional Survey of Sleep-Related Problems in Japanese Visually Impaired Patients: Prevalence and Association with Health-Related Quality of Life

Underexposure to light at work and its association to insomnia and sleepiness

Effect of Reduced Illumination on Insomnia in Office Workers

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