Sleepers Selectively Suppress Informative Inputs during Rapid Eye Movements

Koroma, Matthieu; Lacaux, Célia; Andrillon, Thomas; Legendre, Guillaume; Léger, Damien; Kouider, Sid

doi:10.1016/j.cub.2020.04.047

Cited by 26 publications

(20 citation statements)

References 42 publications

(57 reference statements)

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“…Studying REM-locked brain responses can be contrasted with studying brain activation associated with REM sleep episodes [ 27 , 28 ]. Our event-related fMRI findings showed that REM-locked brain activity is distinct from baseline brain activity during REM sleep [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

fMRI Evidence for Default Mode Network Deactivation Associated with Rapid Eye Movements in Sleep

2021

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System-specific brain responses—time-locked to rapid eye movements (REMs) in sleep—are characteristically widespread, with robust and clear activation in the primary visual cortex and other structures involved in multisensory integration. This pattern suggests that REMs underwrite hierarchical processing of visual information in a time-locked manner, where REMs index the generation and scanning of virtual-world models, through multisensory integration in dreaming—as in awake states. Default mode network (DMN) activity increases during rest and reduces during various tasks including visual perception. The implicit anticorrelation between the DMN and task-positive network (TPN)—that persists in REM sleep—prompted us to focus on DMN responses to temporally-precise REM events. We timed REMs during sleep from the video recordings and quantified the neural correlates of REMs—using functional MRI (fMRI)—in 24 independent studies of 11 healthy participants. A reanalysis of these data revealed that the cortical areas exempt from widespread REM-locked brain activation were restricted to the DMN. Furthermore, our analysis revealed a modest temporally-precise REM-locked decrease—phasic deactivation—in key DMN nodes, in a subset of independent studies. These results are consistent with hierarchical predictive coding; namely, permissive deactivation of DMN at the top of the hierarchy (leading to the widespread cortical activation at lower levels; especially the primary visual cortex). Additional findings indicate REM-locked cerebral vasodilation and suggest putative mechanisms for dream forgetting.

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Section: Introductionmentioning

confidence: 99%

fMRI Evidence for Default Mode Network Deactivation Associated with Rapid Eye Movements in Sleep

2021

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“…For example, electrical responses from the brain during sleep have been investigated in many studies using the individual's own spoken name and other stimuli, but without any interactions that could be construed as two-way communication. [17][18][19][20][21][22][23] Whereas the idea of communicating interactively with sleeping individuals may seem outlandish, the legitimacy of this phenomenon is strongly supported by the following examples of successful two-way communication.…”

Section: Introductionmentioning

confidence: 99%

Real-Time Dialogue between Experimenters and Dreamers During rem Sleep

Konkoly

Appel

Chabani³

et al. 2020

SSRN Journal

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“…(Figure 1A). This phenomenon, however, is not limited to unicellular organisms, as recent studies have described a similar type of communication in cells from multicellular organisms, such as immune cells [2]. Indeed, during immune reactions, some cell types can associate in clusters that may be subjected to a similar quorum-type regulation.…”

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confidence: 98%

“…How does the brain balance these two opposing needs? In an elegantly designed experiment reported in a recent issue of Current Biology, Koroma and colleagues explored how the brain responds to speech during REM sleep [2].…”

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confidence: 99%

“…Here, Koroma and colleagues took it a step further by exploring how the brain's responses to speech vary within REM sleep [2].They used a 'cocktail-party' paradigm, consisting of two streams of speech that are simultaneously played to participants through headphones. One stream, delivered to one ear, contains informative stories, while the other stream, delivered to the other ear, has normal syntactic and phonological structure, but is totally meaningless.…”

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confidence: 99%

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