Sleeve Gastrectomy and Gastric Bypass Decrease the Carotid Intima-Media Thickness in Obese Men: Association with Weight Loss, Cardiovascular Risk Factors, and Circulating Testosterone

Cobeta, Pilar; Osorio, Alvaro; Cuadrado-Ayuso, Marta; García-Moreno, Francisca; Pestaña, David; Galindo, Julio; Botella-Carretero, José I.

doi:10.1007/s11695-020-04405-7

Cited by 11 publications

(22 citation statements)

References 50 publications

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“…Unfortunately, we didn't collect data on hormones change to study the relationship between them and cardiac remodeling. Pilar Cobeta et al in 2020 have reported the change of hormones in 20 patients 6 months after LSG and demonstrated sex hormone-binding globulin and testosterone reduced 6 months later and they were associated with decrease in carotid intimamedia thickness (32). And other hormones such as gastric hormones, intestinal hormones, and pancreatic hormones have been proved to improve after bariatric surgery (33).…”

Section: Discussionmentioning

confidence: 99%

Weight Loss After Laparoscopic Sleeve Gastrectomy Ameliorates the Cardiac Remodeling in Obese Chinese

Meng

Peng

et al. 2022

Front. Endocrinol.

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This study aimed to investigate the impact of weight loss after laparoscopic sleeve gastrectomy (LSG) on cardiac structural and functional remodeling in obese Chinese. A total of 44 obese participants were enrolled consecutively. The physical, laboratory, electrocardiographic, and echocardiographic parameters of pre-and postoperative were recorded. The average follow-up time was 12.28 ± 5.80 months. The body mass index (BMI) of the patients with obesity was decreased from 41.6 ± 7.44 to 30.3 ± 5.73kg/m2 (P<0.001) after LSG. The systolic and diastolic blood pressure of the subjects was significantly reduced from 137.9 ± 15.7mmHg to 123.0 ± 16.0 and 83.4 ± 10.8 to 71.3 ± 11.7mmHg (P<0.001), respectively. The levels of fasting insulin and fasting blood glucose were significantly decreased (38.8 ± 32.1 to 8.43 ± 4.16 mU/L, P<0.001; 6.95 ± 2.59 to 4.64 ± 0.50mmol/L, P<0.001). Total cholesterol (TC, 4.66 ± 0.84 to 4.23 ± 0.75mmol/L, P<0.001) and triglyceride (TG, 1.92 ± 1.21 to 0.85 ± 0.30mmol/L, P<0.001) decreased significantly. Cardiovascular geometric parameters including aortic sinus diameter (ASD, 32.9 ± 2.83mm to 32.0 ± 3.10mm, P<0.05), left atrial diameter (LAD, 38.8 ± 4.03 to 36.2 ± 4.12mm, P<0.001), and interventricular septum thickness(IVS, 10.2 ± 0.93 to 9.64 ± 0.89mm, P<0.001) were significantly reduced. The ratio of weight loss (RWL) was positively correlated with the changes of LAD. The change of IVS was negatively correlated with the change of fasting blood glucose (GLU). Weight loss after LSG could effectively improve cardiac structural, but not functional, abnormality in obese Chinese.

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Section: Discussionmentioning

confidence: 99%

Weight Loss After Laparoscopic Sleeve Gastrectomy Ameliorates the Cardiac Remodeling in Obese Chinese

Meng

Peng

et al. 2022

Front. Endocrinol.

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“…Excess body weight (EBW) was calculated as the difference between baseline body weight and the weight corresponding for a BMI of 25 kg/m2. Data of the change in cIMT of these patients were reported before (10).…”

Section: Patients and Study Designmentioning

confidence: 99%

“…CRP was measured by a high sensitivity colorimetric method (Multigen CRP Vario assay, Sentinel CH, Milan, Italy). Assays and reference ranges for TT, sex hormone-binding globulin (SHBG) were previously reported (10). Fasting insulin was measured by immunochemoluminescence (Immulite 2000, Siemens Healthcare Diagnostics Inc, Gwynedd, UK), with a CV < 10%.…”

Section: Assaysmentioning

confidence: 99%

“…Regarding men submitted to obesity surgery, more than half may present secondary hypogonadism, and its resolution can be achieved in most of them after surgery (22). We have previously shown that the decrease in cIMT correlated with the increase in total testosterone and weight loss after obesity surgery in men (10).…”

Section: Introductionmentioning

confidence: 95%

“…Obesity surgery has shown to diminish cIMT in some previous studies, as reported by meta-analysis (8). We have also recently reported that both Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) induce a similar decrease in cIMT superior to lifestyle modi cation in both women and men with obesity and high cardiovascular risk (9,10).…”

Section: Introductionmentioning

confidence: 99%

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The Amelioration of Inflammation and Endothelial Dysfunction, and the Increase in Testosterone After Obesity Surgery Decreases Carotid Intima-Media Thickness in Men

Cobeta

Pariente

Osorio

et al. 2022

Preprint

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Introduction: Obesity increases cardiovascular risk in men through several mechanisms. Among them, low-grade chronic inflammation and possibly obesity-associated hypogonadism have been described. We aimed to study the association of cardiovascular risk with changes in inflammatory and endothelial dysfunction markers and testosterone. Methods We included 60 men, 20 submitted to laparoscopic Roux-en-Y gastric bypass (RYGB), 20 to sleeve gastrectomy (SG), and 20 to life-style modification (controls). Several inflammatory markers and total testosterone (TT) were measured at baseline and six months after surgery. Free testosterone (FT) was calculated, and carotid intima-media thickness (cIMT) measured by ultrasonography. Results Compared to controls, cIMT decreased after surgery concomitantly with CRP, PAI-1, sICAM-1, IL-18 (P<0.01) and with an increase in sTWEAK (P=0.027), with no differences between RYGB and SG. The increase in TT and FT after surgery correlated with the changes in cIMT (P=0.010 and P=0.038 respectively), but this association disappeared after multivariate analysis. Linear regression showed that sTWEAK (ß=-0.245, P=0.039), PAI-1 (ß=0.346, P=0.005) and CRP (ß=0.236, P=0.049) were associated with the changes in cIMT (R2=0.267, F=6.664, P=0.001). Conclusion Both RYGB and SG in men induced a similar beneficial response on inflammatory and endothelial dysfunction markers that was associated with a decrease in cIMT.

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Association of Bariatric Surgery With Vascular Outcomes

et al. 2021

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IMPORTANCE Bariatric surgical weight loss is associated with reduced cardiovascular mortality; however, the mechanisms underlying this association are incompletely understood.OBJECTIVES To identify variables associated with vascular remodeling after bariatric surgery and to examine how sex, race, and metabolic status are associated with microvascular and macrovascular outcomes. DESIGN, SETTING, AND PARTICIPANTSThis population-based longitudinal cohort included 307 individuals who underwent bariatric surgery. Participants were enrolled in the bariatric weight loss program at Boston Medical Center, a large, multi-ethnic urban hospital, with presurgical and postsurgical assessments. Data were collected from December 11, 2001 to August 27, 2019. Data were analyzed in September 2019. EXPOSURE Bariatric surgery. MAIN OUTCOMES AND MEASURES Flow-mediated dilation (FMD) and reactive hyperemia (RH) (as measures of macrovascular and microvascular function, respectively) and clinical variables were measured preoperatively at baseline and at least once postoperatively within 12 months of the bariatric intervention. RESULTS A total of 307 participants with obesity (mean [SD] age, 42 [12] years; 246 [80%] women; 199 [65%] White; mean [SD] body mass index, 46 [8]) were enrolled in this study. Bariatric surgery was associated with significant weight loss and improved macrovascular and microvascular function across subgroups of sex, race, and traditional metabolic syndrome (mean [SD] pre-vs postsurgery weight: 126 [25] kg vs 104 [25] kg; P < .001; mean [SD] pre-vs postsurgery FMD: 9.1% [5.3] vs 10.2% [5.1]; P < .001; mean [SD] pre-vs postsurgery RH: 764% [400] vs 923% [412]; P < .001). Factors associated with change in vascular phenotype correlated most strongly with adiposity markers and several metabolic variables depending on vascular territory (eg, association of weight change with change in RH: estimate, −3.2; 95% CI, −4.7 to −1.8; association of hemoglobin A 1c with change in FMD:estimate, −0.5; 95% CI, −0.95 to −0.05). While changes in macrovascular function among individuals with metabolically healthy obesity were not observed, the addition of biomarker assessment using high-sensitivity C-reactive protein plasma levels greater than 2 mg/dL identified participants with seemingly metabolically healthy obesity who had low-grade inflammation and achieved microvascular benefit from weight loss surgery. CONCLUSIONS AND RELEVANCEThe findings of this study suggest that bariatric intervention is associated with weight loss and favorable remodeling of the vasculature among a wide range of individuals with cardiovascular risk. Moreover, differences in arterial responses to weight loss surgery (continued) Key Points Question Is bariatric surgical weight loss intervention for obesity associated with microvascular and macrovascular outcomes, and are they differentially associated with sex, race, and metabolic status? Findings In 307 individuals with obesity who were followed up after bariatric surgery, the procedure was associated with ...

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Sleeve Gastrectomy and Gastric Bypass Decrease the Carotid Intima-Media Thickness in Obese Men: Association with Weight Loss, Cardiovascular Risk Factors, and Circulating Testosterone

Cited by 11 publications

References 50 publications

Weight Loss After Laparoscopic Sleeve Gastrectomy Ameliorates the Cardiac Remodeling in Obese Chinese

Weight Loss After Laparoscopic Sleeve Gastrectomy Ameliorates the Cardiac Remodeling in Obese Chinese

The Amelioration of Inflammation and Endothelial Dysfunction, and the Increase in Testosterone After Obesity Surgery Decreases Carotid Intima-Media Thickness in Men

Association of Bariatric Surgery With Vascular Outcomes

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