Abstract-eLine10k is a fast-frame, 64-channel readout ASIC for SLAC Linac Coherent Light Source (LCLS) detectors. The circuit has been designed to integrate the charge from highcapacitance 2D sensors with rolling shutter and 1D strip sensors. It is suitable for applications requiring large input signal range, on the order of 10 4 photons/pixel/pulse at 8keV (22Me -), and a resolution of half a photon FWHM (500e -r.m.s). 2D sensors with a rolling shutter like the X-ray Active Matrix Pixel Sensor (XAMPS), for which the ASIC has been optimized, present several pixels which are bussed on the same readout line. Large input capacitance to each channel is expected leading to stringent noise optimization requirements. The large required number of pixels per channel, and the fixed LCLS beam period impose limitations on the time available for the readout of each single pixel. Giving the periodic nature of the LCLS beam, the ASIC developed for this application is a time-variant system, providing low-noise charge integration, filtering and correlated doublesampling, and a processing speed up to 500k pixel/s on each channel. To cope with the large input dynamic range, a charge pump scheme has been implemented using a synchronous zerobalance measurement method. It provides on-chip 4-bit coarse digital conversion of the integrated charge. The residual charge is sampled using correlated double sampling into an analog memory, multiplexed and measured with the required resolution using an external ADC. In this paper, the ASIC architecture and performance of the final release are presented.