The no-slip boundary condition at a solid-liquid interface is at the center of our understanding of fluid mechanics. However, this condition is an assumption that cannot be derived from first principles and could, in theory, be violated. In this chapter, we present a review of recent experimental, numerical and theoretical investigations on the subject. The physical picture that emerges is that of a complex behavior at a liquid/solid interface, involving an interplay of many physico-chemical parameters, including wetting, shear rate, pressure, surface charge, surface roughness, impurities and dissolved gas.