Slow potential correlates of frontal function, psychosis, and negative symptoms

Bosch, Robert J. van den; Rozendaal, Nico; Mol, J.M.F.

doi:10.1016/0165-1781(88)90010-8

Cited by 19 publications

(6 citation statements)

References 16 publications

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“…This assumption is supported by the fact that some studies have reported that CNV amplitude is correlated with the severity of depression [12,37,38]. More interestingly, reduced CNV amplitude is observed in schizophrenia [39,40].…”

Section: Discussionsupporting

confidence: 67%

Contingent Negative Variation and Personality in Depression

Hansenne¹,

Ansseau²

2001

Neuropsychobiology

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Contingent negative variation (CNV) has been applied in depression with controversial results. A major source for these controversial results could result from the diversity of depressed patients included in the different studies. Supporting this assumption, impulsivity, blunted affect and suicidal behavior significantly influence CNV amplitude. However, no data are available on the possible influences of personality of depressed patients on CNV. Since personality is related to CNV in normal subjects, the aim of the present study was to investigate the relationship between CNV and personality as assessed by the Temperament and Character Inventory (TCI) in 52 depressed patients. A group of 76 healthy volunteers was included in the study. Among depressed patients, the main results of the study shows that CNV amplitude is positively correlated with self-transcendence dimension. In healthy volunteers, results show that CNV amplitude is negatively correlated with novelty seeking and persistence dimensions. The other dimensions are not related to CNV amplitude either in depressed patients or in healthy volunteers. The findings among depressed subjects suggest that lower CNV amplitude may be associated with psychotic traits (high self-transcendence scores), and those observed in healthy subjects are consistent with previous studies and support energetical models of slow potentials. However, the preliminary nature of the present results with respect to the weak statistical significance should be underlined.

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Section: Discussionsupporting

confidence: 67%

Contingent Negative Variation and Personality in Depression

Hansenne¹,

Ansseau²

2001

Neuropsychobiology

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“…19 The fact that such a pattern is present in a number of severe psychiatric disorders suggests that PTSD may have commonalities with these disorders not previously appreciated. Prior investigators generally have interpreted such increased frontal CNVs as representative of increased frontal activation due to inefficient frontal functioning 20 and found that such ratios correlate with performance on a test of frontal functioning. While the heightened frontal amplitudes do not directly indicate an underlying frontal hyperactivation, it is worthy to note that findings are consistent with a growing literature that establishes the presence of frontal lobe abnormalities in subjects with PTSD.…”

Section: Discussionmentioning

confidence: 99%

A CNV-Distraction Paradigm in Combat Veterans With Posttraumatic Stress Disorder

Kimble¹

2004

Journal of Neuropsychiatry

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Fourteen veterans with posttraumatic stress disorder (PTSD) and 14 without PTSD participated in a contingent negative variation (CNV)-distraction paradigm. Subjects were instructed to press a button after hearing a high-pitched tone (S2) preceded by a low-pitched tone (S1). One-half of the trials included a white-noise distracter placed in the S1-S2 interval. Posttraumatic stress disorder subjects had larger frontal, but smaller central and parietal CNVs, regardless of condition (distracter, no distracter) or epoch (early CNV, late CNV). In PTSD subjects, the N1/P2 complex was smaller to warning (S1) and distracter stimuli and did not show the extent of facilitation present in non-PTSD subjects. Findings highlight PTSD-related differences in phasic cortical excitability and attention.

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“…87 In addition, a few studies report that higher anhedonia correlates with less frontal activation while performing cognitive tasks and with certain psychophysiological abnormalities. 68,94,95 A growing number of studies have examined relations between anhedonia and emotional experience during laboratory paradigms involving evocative stimuli. Findings thus far are mixed, with some reporting significant associations 78,87,96 and others not.…”

Section: Studies Based On Anhedonia Questionnairesmentioning

confidence: 99%

Affective Traits in Schizophrenia and Schizotypy

Horan

Blanchard

Clark

et al. 2008

Schizophrenia Bulletin

256

225

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This article reviews empirical studies of affective traits in individuals with schizophrenia spectrum disorders, population-based investigations of vulnerability to psychosis, and genetic and psychometric high-risk samples. The review focuses on studies that use self-report trait questionnaires to assess Negative Affectivity (NA) and Positive Affectivity (PA), which are conceptualized in contemporary models of personality as broad, temperamentally-based dispositions to experience corresponding emotional states. Individuals with schizophrenia report a pattern of stably elevated NA and low PA throughout the illness course. Among affected individuals, these traits are associated with variability in several clinically important features, including functional outcome, quality of life, and stress reactivity. Furthermore, evidence that elevated NA and low PA (particularly the facet of anhedonia) predict the development of psychosis and are detectable in high-risk samples suggests that these traits play a role in vulnerability to schizophrenia, though they are implicated in other forms of psychopathology as well. Results are discussed in terms of their implications for treatment, etiological models, and future research to advance the study of affective traits in schizophrenia and schizotypy.

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Slow potential correlates of frontal function, psychosis, and negative symptoms

Cited by 19 publications

References 16 publications

Contingent Negative Variation and Personality in Depression

Contingent Negative Variation and Personality in Depression

A CNV-Distraction Paradigm in Combat Veterans With Posttraumatic Stress Disorder

Affective Traits in Schizophrenia and Schizotypy

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