Slow release of wound healing drug from hydrogel wound dressing prepared by radiation crosslinking method

Wu, Weibin; Peizhi, Sung; Wang, Xingguo; Li, Jinghui; Chen, Jie; Yang, Yueqi; Shen, Yihao; Ma, Zhijun

doi:10.1016/0969-806x(93)90409-n

Cited by 4 publications

(4 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From 60 case studies of the clinical effects, the result showed that slow drug releasing relieves the pain effectively for prolonged period of application. The dressing can reduce wound oozing, make the wound heal faster, and reduce number of dressing changes required 17…”

Section: Introductionmentioning

confidence: 99%

Preparation of carboxymethyl sago pulp hydrogel from sago waste by electron beam irradiation and swelling behavior in water and various pH media

Pushpamalar

Langford

Ahmad

et al. 2012

J of Applied Polymer Sci

View full text Add to dashboard Cite

Solutions of carboxymethyl sago pulp (CMSP) of various degree of substitution were irradiated with electron beam of various radiation doses. The gelation dose (D g ) and p o /q o ratio (p o is degradation density, q o is crosslinking density) is dependent on CMSP concentration and degree of substitution. In the range of concentrations of 10% to 80% (w/v) CMSP with degree of substitutions of 0.4, 0.6, and 0.8, the p o /q o ratio decreases with increasing %CMSP showing that crosslinking processes are dominating and increasing the gel network of the CMSP hydrogel. The fourier transform infrared spectra of CMSP hydrogels of degree of substitutions of 0.4, 0.6, and 0.8 with percentage of gel fractions 25, 35, and ! 40 show differences in the intensity of the absorption bands at 1020-1100, 1326, and 1422 cm À1 with different degree of substitutions and percentage of gel fraction (%GF) that correspond to different extents of chain scission and crosslinking. The swelling behavior in water shows that CMSP hydrogels could absorb 3500-5300% of water by 1 g of CMSP hydrogel. The ability to absorb water increases with the decrease of degree of substitution and %GF of the CMSP hydrogels. It is also observed that the optimum pH for swelling CMSP hydrogel is at pH 7.

show abstract

Section: Introductionmentioning

confidence: 99%

Preparation of carboxymethyl sago pulp hydrogel from sago waste by electron beam irradiation and swelling behavior in water and various pH media

Pushpamalar

Langford

Ahmad

et al. 2012

J of Applied Polymer Sci

View full text Add to dashboard Cite

show abstract

“…432,436 Data on the biological and physical properties of the hydrogels used as dressings have been described and compared with the usual muslin bandages. 441 The influence of the irradiation dose on the mechanical properties of poly(Nvinylpyrrolidone) gels filled with agar and poly(ethylene glycol) has been studied (Fig. 1).…”

Section: The Use Of Radiation-induced Cross-linking For the Preparati...mentioning

confidence: 99%

Preparation of polymeric biomaterials with the aid of radiation-chemical methods

Kabanov¹

1998

Russ. Chem. Rev.

View full text Add to dashboard Cite

“…The development of hydrogels started in the beginning of the 1960s with the production of 2‐hydroxyethylmethacrylate (HEMA)‐based polymers,2 which had a swelling capacity of 40–50%. These highly hydrophilic polymers were mainly used in sanitary products, such as diapers,3 materials for wound closure,4, 5 intraocular and contact lenses,6–9 soil improvement, and vegetal growth 10…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of a porous poly(hydroxyethylmethacrylate‐co‐ethylene glycol dimethacrylate)‐based hydrogel device for the implantable delivery of insulin

Kumar

Tyagi

Singh

et al. 2012

J of Applied Polymer Sci

View full text Add to dashboard Cite

Poly(hydroxyethylmethacrylate-co-ethylene glycol dimethacrylate) [poly(HEMA-co-EGDMA)]-based hydrogel devices were synthesized by a free-radical polymerization reaction with 2-hydroxyethylmethacrylate as the monomer, different concentrations of ethylene glycol dimethacrylate (EGDMA) as the crosslinking agent, and ammonium persulfate/N,N,N 0 ,N 0 -tetra-methyl ethylenediamine as the free-radical initiator. The porosity of the poly(HEMA-co-EGDMA) hydrogels was controlled with water as the porogen. The Fourier transform infrared spectrum of poly(HEMA-co-EGDMA) showed absorption bands associated with AC¼ ¼O stretching at 1714 cm À1 , CAOAC stretching vibrations at 1152 cm À1 , and a broad band at 3500-3800 cm À1 corresponding to AOH stretching. Atomic force microscopy studies showed that the hydrogel containing 67% water had pores in the range of 3500-9000 nm, whereas the hydrogel containing 7% water did not show measurable pores. The hydrogel synthe-sized with 1% EGDMA showed 50% thallium-201 release within the first 30 min and about 80% release within 60 min. In vitro insulin-release studies suggested that the hydrogel with 27% water showed sustained release up to 120 min, whereas the hydrogels with 47 and 67% water showed that nearly all of the insulin was released within 60 min. Hydrogel devices synthesized with 27% water and filled with insulin particles showed sustained release for up to 8 days, whereas the hydrogels synthesized with 47 and 67% water released insulin completely within 3 days of administration. Animal studies suggested that the hydrogel devices synthesized with 27% water and filled with insulin-loaded particles (120 IU) were able to control blood glucose levels for up to 5 days after implantation. V C 2012 Wiley Periodicals, Inc. J Appl Polym Sci 126: [894][895][896][897][898][899][900][901][902][903][904][905] 2012

show abstract

Slow release of wound healing drug from hydrogel wound dressing prepared by radiation crosslinking method

Cited by 4 publications

References 1 publication

Preparation of carboxymethyl sago pulp hydrogel from sago waste by electron beam irradiation and swelling behavior in water and various pH media

Preparation of carboxymethyl sago pulp hydrogel from sago waste by electron beam irradiation and swelling behavior in water and various pH media

Preparation of polymeric biomaterials with the aid of radiation-chemical methods

Synthesis and characterization of a porous poly(hydroxyethylmethacrylate‐co‐ethylene glycol dimethacrylate)‐based hydrogel device for the implantable delivery of insulin

Contact Info

Product

Resources

About