During the era of COVID-19 (COronaVIrus Disease of 2019), telework has been adopted extensively in developing countries for the first time. This study analyzes data of 355 teleworkers in Hanoi (Vietnam) during April 2020, the period of social distancing, to examine various factors associated with (1) complete home-based telework (HBT), (2) the perception of HBT, and (3) the attitude toward the combination between HBT and conventional work at workplace post-COVID-19. It finds that the company's closure policy and the frequency of working from a distance before the social distancing period were the primary determinants of exclusively teleworking. Regarding the perception of HBT, while the fear of COVID-19 was a strong positive factor, difficulties in focusing on work and accessing data were negative factors. Regarding the attitude toward the future development of HBT, attitudinal factors, commute distance, gender, children in household, and the perception of HBT in the social distancing period were the main predictors. The presence of more than one child negatively affected the perception of telework but positively affected the attitude toward establishing the hybrid work mechanism. The findings suggested that HBT has the potential to alleviate traffic congestion in developing countries and it can be promoted by emphasizing its environment-related benefits. The sample used in this research was collected in the initial stage of constrained mobility and it was not well representative; therefore, this study serves as a proof of concept for ongoing wider analyses on HBT post-COVID-19 or in the subsequent lockdown periods.