Small angle X-ray scattering study of poly(N-isopropyl acrylamide) based cryogels near the volume-phase transition temperature

Chalal, Mohand; Ehrburger‐Dolle, Françoise; Morfin, Isabelle; Armas, M.A.; López, Maria-Luisa; Bley, F.

doi:10.1088/1742-6596/247/1/012041

Cited by 4 publications

(1 citation statement)

References 39 publications

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“…Based on the Guinier equation [ 30 ], the Guinier radius values of gyration ( R g ) can be computed from SAXS data in the low- q regions as follows:

where I G (0) is the asymptotic value of the Guinier intensity when the scattering vector ( q ) is close to 0. Herein, the R g values should be linked to the aggregated size of the prepared P(NA-AA)−0−y stemming from their cross-link domains and their maximum diameter ( D max ) [ 31 , 32 ].…”

Section: Resultsmentioning

confidence: 99%

Dispersion Performances and Fluorescent Behaviors of Naphthalic Anhydride Doped in Poly(acrylic acid) Frameworks for pH-Sensitive Ibuprofen Delivery via Fractal Evolution

Cui

Wang

et al. 2023

Polymers

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The pH-responsive fluorescent P(1,8-naphthalic anhydride (NA)-acrylic acid (AA)) matrix was successfully prepared by a doping method using poly(acrylic acid) (PAA) as a pH-sensitive polymer and NA as a fluorescent tracer. The fluorescent behaviors of the used NA dispersed in PAA frameworks were demonstrated based on fractal features combined with various characterizations, such as small-angle X-ray scattering (SAXS) patterns, photoluminescence (PL) spectra, scanning electron microscope (SEM) images, thermogravimetry (TG) profiles, Fourier transform infrared (FT-IR) spectroscopy, and time-resolved decays. The effects of NA-doping on the representative fluorescent P(NA-AA) were investigated, in which the fluorescent performance of the doped NA was emphasized. The results indicated that aggregated clusters of the doped NA were gradually serious with an increase in NA doping amount or extension of NA doping time, accompanied by an increase in mass fractal dimension (Dm) values. Meanwhile, the doped NA presented stable fluorescent properties during the swelling–shrinking process of PAA. Ibuprofen (IBU) was used as a model drug, and fractal evolutions of the obtained P(NA-AA) along with the drug loading and releasing behaviors were evaluated via SAXS patterns, in which the drug-loaded P(NA-AA) presented surface fractal (Ds) characteristics, while the Dm value varied from 2.94 to 2.58 during sustained drug-release in pH 2.0, indicating occurrences of its structural transformation from dense to loose with extension of IBU-releasing time. Finally, the cytotoxicity and cellular uptake behaviors of the obtained P(NA-AA) were preliminarily explored. These demonstrations revealed that the resultant P(NA-AA) should be a potential intelligent-responsive drug carrier for targeted delivery.

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“…Based on the Guinier equation [ 30 ], the Guinier radius values of gyration ( R g ) can be computed from SAXS data in the low- q regions as follows:

Section: Resultsmentioning

confidence: 99%

Dispersion Performances and Fluorescent Behaviors of Naphthalic Anhydride Doped in Poly(acrylic acid) Frameworks for pH-Sensitive Ibuprofen Delivery via Fractal Evolution

Cui

Wang

et al. 2023

Polymers

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Fractal features of dual temperature/pH-sensitive poly(N-isopropylacrylamide-co-acrylic acid) hydrogels and resultant effects on the controlled drug delivery performances

Sun

Bing

et al. 2022

European Polymer Journal

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A Small-Angle X-ray Scattering Study of the Development of Morphology in Films Formed from the 3M Perfluorinated Sulfonic Acid Ionomer

et al. 2012

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An extensive SAXS investigation of the 3M perfluorinated sulfonic acid ionomer was performed to investigate the morphological changes that occur during and after annealing at temperatures above the T α. The effect of film thickness in the range studied, 11–45 μm, was found to be negligible. These properties were studied as a function of equivalent weight from 700 to 1100 and correlated with the water uptake as measured by dynamic vapor sorption. Isoscattering points were observed in dynamic annealing experiments of the unboiled annealed films at q = 0.023, 0.096 Å–1. On initial water uptake these films also showed isoscattering points at q = 0.024, 0.220 Å–1; q = 0.029, 0.223 Å–1; and q = 0.030, 0.211 Å–1 at 50, 80, or 95 °C, respectively, indicating a decrease in the symmetry of the scattering objects in these size regimes. Isoscattering points were absent in similar water uptake experiment for the films after boiling.

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Small angle X-ray scattering study of poly(N-isopropyl acrylamide) based cryogels near the volume-phase transition temperature

Cited by 4 publications

References 39 publications

Dispersion Performances and Fluorescent Behaviors of Naphthalic Anhydride Doped in Poly(acrylic acid) Frameworks for pH-Sensitive Ibuprofen Delivery via Fractal Evolution

Dispersion Performances and Fluorescent Behaviors of Naphthalic Anhydride Doped in Poly(acrylic acid) Frameworks for pH-Sensitive Ibuprofen Delivery via Fractal Evolution

Fractal features of dual temperature/pH-sensitive poly(N-isopropylacrylamide-co-acrylic acid) hydrogels and resultant effects on the controlled drug delivery performances

A Small-Angle X-ray Scattering Study of the Development of Morphology in Films Formed from the 3M Perfluorinated Sulfonic Acid Ionomer

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