Small animal PET imaging with germanium strip detectors

Phlips, Bernard F.; Kroeger, R. A.; Kurfess, J. D.; Johnson, W. N.; Wulf, E.

doi:10.1109/nssmic.2002.1239591

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…However, the other properties, and in particular the need for cryogenic cooling and cost make the choice rather impractical at least for clinical PET. Their use for a dedicated small animal PET system is, however, not excluded (Philips et al 2002). A much more feasible way to improve the resolution of 3γ imaging is through the reconstruction process.…”

Section: Outstanding Questions and Directions Of Future Studiesmentioning

confidence: 99%

Performance of three-photon PET imaging: Monte Carlo simulations

Kacperski

Spyrou

2005

Phys. Med. Biol.

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We have recently introduced the idea of making use of three-photon positron annihilations in positron emission tomography. In this paper, the basic characteristics of the three-gamma imaging in PET are studied by means of Monte Carlo simulations and analytical computations. Two typical configurations of human and small animal scanners are considered. Three-photon imaging requires high-energy resolution detectors. Parameters currently attainable by CdZnTe semiconductor detectors, the technology of choice for the future development of radiation imaging, are assumed. Spatial resolution is calculated as a function of detector energy resolution and size, position in the field of view, scanner size and the energies of the three-gamma annihilation photons. Possible ways to improve the spatial resolution obtained for nominal parameters, 1.5 cm and 3.2 mm FWHM for human and small animal scanners, respectively, are indicated. Counting rates of true and random three-photon events for typical human and small animal scanning configurations are assessed. A simple formula for minimum size of lesions detectable in the three-gamma based images is derived. Depending on the contrast and total number of registered counts, lesions of a few mm size for human and sub mm for small animal scanners can be detected.

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Section: Outstanding Questions and Directions Of Future Studiesmentioning

confidence: 99%

Performance of three-photon PET imaging: Monte Carlo simulations

Kacperski

Spyrou

2005

Phys. Med. Biol.

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show abstract

“…Segmenting the electrodes and observing the time dependence of collected charge signals (both real and image) allow the determination of photon interaction points, both in coaxial and planar detectors. Large area planar germanium multi-electrode detectors have been built for medical imaging [1][2][3], space science [4][5][6], homeland security [7][8][9], Doppler correction [10] and gamma-ray polarization measurements [11,12]. The detector technology has advanced significantly, both in the size of detector crystals and in the methods of segmentation.…”

Section: Introductionmentioning

confidence: 99%